Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease
Zhao L, Grosser T, Fries S, Kadakia L, Wang H, Zhao J, Falotico R. Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease. Expert Review Of Clinical Immunology 2006, 2: 649-658. PMID: 20477620, DOI: 10.1586/1744666x.2.4.649.Peer-Reviewed Original ResearchCardiovascular diseaseCOX-2-derived prostaglandinsAortic aneurysm pathogenesisLow-density lipoprotein oxidationTh1 cytokine productionInflammatory chemokine productionInflammatory lipid mediatorsMonocyte-endothelial cell interactionsSelective inhibitionCertain cardiovascular diseasesHuman cardiovascular diseaseSystemic drug deliveryCardiovascular eventsChemokine productionCytokine productionBiosynthesis of leukotrienesDeficient miceCOX-2Murine modelLipoprotein oxidationLipid mediatorsMouse modelTherapeutic benefitCOX-1Aneurysm pathogenesis