1990
Effect of artificial surfactant on pulmonary function in preterm and full-term lambs
Gladstone I, Ray A, Salafia C, Perez-Fontan J, Mercurio M, Jacobs H. Effect of artificial surfactant on pulmonary function in preterm and full-term lambs. Journal Of Applied Physiology 1990, 69: 465-472. PMID: 2121700, DOI: 10.1152/jappl.1990.69.2.465.Peer-Reviewed Original ResearchConceptsFunctional residual capacityFull-term lambsMean lung volumePreterm lambsLung volumeResidual capacityTest agentsFC-100Higher minimum surface tensionsRespiratory failureLung functionPulmonary functionLung expansionAlveolar washMinimum surface tensionDynamic complianceArtificial surfactantQualitative histologyOxygenationLambsAgentsGas exchangePretermComplianceHistology
1989
Antenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits
Gladstone I, Mercurio M, Devenny S, Jacobs H. Antenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits. Journal Of Applied Physiology 1989, 67: 1377-1382. PMID: 2793738, DOI: 10.1152/jappl.1989.67.4.1377.Peer-Reviewed Original ResearchConceptsDynamic compliancePulmonary functionLung resistanceTotal lung conductanceTotal lung resistancePulmonary function testsRespiratory distress syndromeConsistent tidal volumeAntenatal corticosteroidsAntenatal steroidsIntramuscular betamethasonePostnatal surfactantDistress syndromeFunction testsCombination therapyPulmonary mechanicsExpiratory timePremature rabbitsTidal volumeStatic complianceLung conductanceFirst breathDay 27Day 25Steroids
1986
Left ventricular performance and contractility before and after volume infusion: a comparative study of preterm and full-term newborn lambs.
Baylen B, Ogata H, Ikegami M, Jacobs H, Jobe A, Emmanouilides G. Left ventricular performance and contractility before and after volume infusion: a comparative study of preterm and full-term newborn lambs. Circulation 1986, 73: 1042-1049. PMID: 3754496, DOI: 10.1161/01.cir.73.5.1042.Peer-Reviewed Original ResearchConceptsFull-term lambsLeft ventricular performanceVolume infusionPreterm lambsVentricular performanceStroke workLeft ventricular peak dP/dtLeft ventricleVentricular peak dP/dtLeft ventricular end-diastolic volumeFull-term newborn lambsVentricular end-diastolic volumeLeft ventricular stroke workPeak dP/dtGreater stroke workPostnatal circulatory adaptationSystemic vascular resistanceVentricular stroke workFull-term animalsDays gestational ageEnd-diastolic volumeLeft ventricular pressureDP/dtVascular resistancePulmonary function