2024
Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk
Marini S, Kimball T, Mayerhofer E, Tack R, Senff J, Prapiadou S, Rivier C, Duskin J, Kourkoulis C, Falcone G, Yechoor N, Tanzi R, Rosand J, Singh S, Parodi L, Anderson C. Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk. Neurology 2024, 103: e210014. PMID: 39504504, DOI: 10.1212/wnl.0000000000210014.Peer-Reviewed Original ResearchConceptsLate-life depressionGenetic riskDementia riskUK Biobank (UKBEffects of healthy lifestylesHealth-related behaviorsGenetic predispositionElevated genetic riskProspective cohort studyHazard of strokeCox proportional hazards modelsAge-related brain diseasesLifestyle behaviorsCare scoresUKB participantsProportional hazards modelHealthy lifestyleIncidence of strokeMultivariate Cox proportional hazards modelPolygenic scoresTargeted interventionsLifestyle adjustmentsAggregate risk estimatesRisk estimatesCohort studyEndovascular Treatment of Acute Ischemic Stroke After Cardiac Interventions in the United States
de Havenon A, Zhou L, Koo A, Matouk C, Falcone G, Sharma R, Ney J, Shu L, Yaghi S, Kamel H, Sheth K. Endovascular Treatment of Acute Ischemic Stroke After Cardiac Interventions in the United States. JAMA Neurology 2024, 81: 264-272. PMID: 38285452, PMCID: PMC10825786, DOI: 10.1001/jamaneurol.2023.5416.Peer-Reviewed Original ResearchNational Institutes of Health Stroke ScaleNational Institutes of Health Stroke Scale scoreOdds of discharge homeDischarged homeIschemic strokeRate of endovascular thrombectomyMultivariate logistic regressionNational Inpatient Sample databaseHealth Stroke ScaleIntervention patientsInpatient Sample databaseMain OutcomesIntervention statusHospitalization of patientsPotential confoundersUS hospitalsEndovascular thrombectomyStroke patientsCohort studySecondary outcomesLogistic regressionCardiac interventionsStroke severityStroke ScaleGroup of hospitalized patients
2022
Analysis of Clinical Traits Associated With Cardiovascular Health, Genomic Profiles, and Neuroimaging Markers of Brain Health in Adults Without Stroke or Dementia
Acosta JN, Both CP, Rivier C, Szejko N, Leasure AC, Gill TM, Payabvash S, Sheth KN, Falcone GJ. Analysis of Clinical Traits Associated With Cardiovascular Health, Genomic Profiles, and Neuroimaging Markers of Brain Health in Adults Without Stroke or Dementia. JAMA Network Open 2022, 5: e2215328. PMID: 35622359, PMCID: PMC9142873, DOI: 10.1001/jamanetworkopen.2022.15328.Peer-Reviewed Original ResearchConceptsBrain healthBrain volumeMagnetic resonance imagingLower mean volumeLifestyle factorsCardiovascular healthLarge population-based cohort studyLife's Simple 7 (LS7) scoresPopulation-based cohort studyBrain magnetic resonance imagingMean volumeWhite matter hyperintensity volumeBrain health benefitsCommunity-dwelling personsImproved brain healthOutcomes of interestUK BiobankFinal analytical sampleAsymptomatic personsCohort studyLS7 scoreNeuroimaging markerHyperintensity volumeMAIN OUTCOMEGenetic predisposition
2021
Risk of Mortality After an Arterial Ischemic Event Among Intracerebral Hemorrhage Survivors
Parasram M, Parikh NS, Merkler AE, Falcone GJ, Sheth KN, Navi BB, Kamel H, Zhang C, Murthy SB. Risk of Mortality After an Arterial Ischemic Event Among Intracerebral Hemorrhage Survivors. The Neurohospitalist 2021, 12: 19-23. PMID: 34950382, PMCID: PMC8689534, DOI: 10.1177/19418744211026709.Peer-Reviewed Original ResearchArterial ischemic eventsRisk of deathIschemic eventsIntracerebral hemorrhageMyocardial infarctionIschemic strokeMarginal structural modelsICH patientsMedicare beneficiariesNon-traumatic intracerebral hemorrhageICD-9-CM diagnosis codesAcute ischemic strokeRetrospective cohort studySubsequent ischemic strokeIntracerebral hemorrhage survivorsRisk of mortalityICH survivorsMedian followElderly patientsCohort studyDiagnosis codesClaims dataMortality riskMortality rateTime-varying covariates
2020
Association of race and ethnicity to incident epilepsy, or epileptogenesis, after subdural hematoma.
Brown SC, King ZA, Kuohn L, Kamel H, Gilmore EJ, Frontera JA, Murthy S, Kim JA, Omay SB, Falcone GJ, Sheth KN. Association of race and ethnicity to incident epilepsy, or epileptogenesis, after subdural hematoma. Neurology 2020, 95: e2890-e2899. PMID: 32907969, PMCID: PMC7734738, DOI: 10.1212/wnl.0000000000010742.Peer-Reviewed Original ResearchConceptsSubdural hematomaEmergency departmentMultivariable Cox regressionRetrospective cohort studyMedical risk factorsDevelopment of epilepsyNontraumatic subdural hematomaAssociation of raceDiagnosis of epilepsyCohort studyPrimary outcomeRenal diseaseStatus epilepticusWhite patientsBlack patientsHospital revisitsCox regressionBlack raceDiagnosis codesRisk factorsClaims dataInjury severityEpilepsyDrug useSurvival analysisCombining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage
Biffi A, Urday S, Kubiszewski P, Gilkerson L, Sekar P, Rodriguez-Torres A, Bettin M, Charidimou A, Pasi M, Kourkoulis C, Schwab K, DiPucchio Z, Behymer T, Osborne J, Morgan M, Moomaw CJ, James ML, Greenberg SM, Viswanathan A, Gurol ME, Worrall BB, Testai FD, McCauley JL, Falcone GJ, Langefeld CD, Anderson CD, Kamel H, Woo D, Sheth KN, Rosand J. Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage. Stroke 2020, 51: 2153-2160. PMID: 32517581, PMCID: PMC7311289, DOI: 10.1161/strokeaha.120.028310.Peer-Reviewed Original ResearchConceptsCortical superficial siderosisICH recurrenceCerebral microbleedsSuperficial siderosisIntracerebral hemorrhageRecurrent ICHMRI markersOral anticoagulation therapyPotent risk factorRecurrent hemorrhagic strokeLongitudinal cohort studyLow-risk categoryLow-risk individualsΕ2/ε4ICH survivorsAnticoagulation therapyCohort studyHemorrhagic strokeProspective studyRecurrence rateΕ4 variantRisk factorsClinical impactERICH studyΕ4 alleleNon-Traumatic Subdural Hemorrhage and Risk of Arterial Ischemic Events
Murthy SB, Wu X, Diaz I, Parasram M, Parikh NS, Iadecola C, Merkler AE, Falcone GJ, Brown S, Biffi A, Ch'ang J, Knopman J, Stieg PE, Navi BB, Sheth KN, Kamel H. Non-Traumatic Subdural Hemorrhage and Risk of Arterial Ischemic Events. Stroke 2020, 51: 1464-1469. PMID: 32178587, PMCID: PMC7188584, DOI: 10.1161/strokeaha.119.028510.Peer-Reviewed Original ResearchConceptsArterial ischemic eventsAcute ischemic strokeIschemic eventsIschemic strokeSubdural hemorrhageMyocardial infarctionAntithrombotic therapyMedicare beneficiariesSDH diagnosisPatient riskSecondary analysisRetrospective cohort studyAcute myocardial infarctionCohort studyHazard ratioSecondary outcomesVascular comorbiditiesPrimary outcomeCox regressionDiagnosis codesClaims dataInternational ClassificationPrimary analysisInfarctionStroke
2019
Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage
Dhar R, Falcone GJ, Chen Y, Hamzehloo A, Kirsch EP, Noche RB, Roth K, Acosta J, Ruiz A, Phuah CL, Woo D, Gill TM, Sheth KN, Lee JM. Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage. Stroke 2019, 51: 648-651. PMID: 31805845, PMCID: PMC6993878, DOI: 10.1161/strokeaha.119.027657.Peer-Reviewed Original ResearchConceptsSupratentorial intracerebral hemorrhagePerihematomal edemaIntracerebral hemorrhagePHE volumeResults Two hundred twentyIntracerebral Hemorrhage (ERICH) studyMechanism of injuryIntracerebral hemorrhage patientsSpontaneous intracerebral hemorrhageLarge cohort studyComputed tomography scanSecondary outcomesCohort studyPrimary outcomeHemorrhage patientsSecondary injuryTomography scanHundred twentyMedian volumeLarge cohortHemorrhagePatientsQuantification of hemorrhageFirst cohortDisease biology
2018
Minority Patients are Less Likely to Undergo Withdrawal of Care After Spontaneous Intracerebral Hemorrhage
Ormseth CH, Falcone GJ, Jasak SD, Mampre DM, Leasure AC, Miyares LC, Hwang DY, James ML, Testai FD, Becker KJ, Tirschwell DL, Langefeld CD, Woo D, Sheth KN. Minority Patients are Less Likely to Undergo Withdrawal of Care After Spontaneous Intracerebral Hemorrhage. Neurocritical Care 2018, 29: 419-425. PMID: 29949003, PMCID: PMC6286261, DOI: 10.1007/s12028-018-0554-4.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageHematoma volumeAdmission Glasgow Coma ScaleEthnic/Racial VariationsNon-traumatic intracerebral hemorrhageIntracerebral Hemorrhage (ERICH) studyProspective cohort studyGlasgow Coma ScaleIntensive care unitWithdrawal of careSpontaneous intracerebral hemorrhageSimilar mortality ratesLogistic regression analysisRace/ethnicity modifiesRace/ethnicityCMO patientsHospital mortalityCohort studyRankin ScaleWhite patientsComa ScaleBlack patientsCare unitEndotracheal intubationICH patients
2016
Cortical superficial siderosis predicts early recurrent lobar hemorrhage
Roongpiboonsopit D, Charidimou A, William CM, Lauer A, Falcone GJ, Martinez-Ramirez S, Biffi A, Ayres A, Vashkevich A, Awosika OO, Rosand J, Gurol ME, Silverman SB, Greenberg SM, Viswanathan A. Cortical superficial siderosis predicts early recurrent lobar hemorrhage. Neurology 2016, 87: 1863-1870. PMID: 27694268, PMCID: PMC5100711, DOI: 10.1212/wnl.0000000000003281.Peer-Reviewed Original ResearchConceptsCortical superficial siderosisConvexity subarachnoid hemorrhageCerebral amyloid angiopathyRecurrent ICHSuperficial siderosisAcute convexity subarachnoid hemorrhageDisseminated cortical superficial siderosisSingle-center cohort studyBaseline ICH volumeRecurrent lobar hemorrhageProportional hazards modelWhite matter hyperintensitiesIntracerebral hemorrhage recurrenceLobar hemorrhageLobar ICHSymptomatic ICHBoston criteriaConsecutive survivorsCohort studyAmyloid angiopathyHemorrhage recurrenceIndependent predictorsUnivariable analysisCerebral microbleedsIndex eventEndovascular Stroke Treatment Outcomes After Patient Selection Based on Magnetic Resonance Imaging and Clinical Criteria
Leslie-Mazwi TM, Hirsch JA, Falcone GJ, Schaefer PW, Lev MH, Rabinov JD, Rost NS, Schwamm L, González RG. Endovascular Stroke Treatment Outcomes After Patient Selection Based on Magnetic Resonance Imaging and Clinical Criteria. JAMA Neurology 2016, 73: 1-7. PMID: 26524074, DOI: 10.1001/jamaneurol.2015.3000.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSelection of patientsClinical criteriaFavorable outcomeSuccessful reperfusionMRS scoreLTB patientsIschemic strokeTerminal internal carotid artery occlusionResonance imagingInternal carotid artery occlusionStroke treatment outcomesEndovascular stroke treatmentAcute ischemic strokeCarotid artery occlusionProspective cohort studyMiddle cerebral arterySpecific magnetic resonance imagingInfarct volume determinationArtery occlusionCohort studyStroke treatmentCerebral arteryEndovascular treatmentPatient selection
2015
Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: Results from five cohort studies
Fondell E, O’Reilly É, Fitzgerald KC, Falcone GJ, Kolonel LN, Park Y, Gapstur SM, Ascherio A. Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: Results from five cohort studies. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2015, 16: 366-371. PMID: 25822002, PMCID: PMC4589421, DOI: 10.3109/21678421.2015.1020813.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisMultivariable-adjusted risk ratiosALS riskRisk ratioCohort studyLateral sclerosisCases of ALSCox proportional hazards regressionProportional hazards regressionLarge cohort studyIntake of caffeineAdenosine A2A receptorsRandom-effects modelConsumption of caffeineHazards regressionALS incidenceLowest quintileMotor neuronsCaffeine intakeA2A receptorsAssociation of caffeineLarger studyIntakeSclerosisRisk
2014
Dietary ω-3 Polyunsaturated Fatty Acid Intake and Risk for Amyotrophic Lateral Sclerosis
Fitzgerald KC, O’Reilly É, Falcone GJ, McCullough ML, Park Y, Kolonel LN, Ascherio A. Dietary ω-3 Polyunsaturated Fatty Acid Intake and Risk for Amyotrophic Lateral Sclerosis. JAMA Neurology 2014, 71: 1102-1110. PMID: 25023276, PMCID: PMC4160351, DOI: 10.1001/jamaneurol.2014.1214.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisMultivariable-adjusted risk ratiosALS riskRisk ratioHealth StudyLateral sclerosisCancer Prevention Study II Nutrition CohortPolyunsaturated Fatty Acid IntakeCox proportional hazards regressionOnset of ALSHealth Professionals FollowHealth-AARP DietNurses' Health StudyFood frequency questionnaireFatty acid intakeSevere progressive diseaseProportional hazards regressionMultiethnic Cohort StudyRandom-effects methodDietary ωNutrition CohortProfessionals FollowCohort studyFrequency questionnaireProgressive diseaseMortality of patients with multiple sclerosis: a cohort study in UK primary care
Jick SS, Li L, Falcone GJ, Vassilev ZP, Wallander M. Mortality of patients with multiple sclerosis: a cohort study in UK primary care. Journal Of Neurology 2014, 261: 1508-1517. PMID: 24838537, PMCID: PMC4119255, DOI: 10.1007/s00415-014-7370-3.Peer-Reviewed Original ResearchConceptsCause of deathMS patientsCause mortalityHazard ratioMS casesUK General Practice Research DatabaseGeneral Practice Research DatabaseLarge population-based cohortFirst MS diagnosisMortality of patientsFemale MS patientsCox proportional regressionMultiple sclerosis patientsPopulation-based cohortUK primary careConfidence intervalsDifferent hazard ratiosHR 1.7Index dateCohort studyYounger patientsHigher proportionSclerosis patientsMS diagnosisMultiple sclerosisDietary Fiber and Amyotrophic Lateral Sclerosis: Results From 5 Large Cohort Studies
Fondell E, O'Reilly É, Fitzgerald KC, Falcone GJ, Kolonel LN, Park Y, McCullough ML, Ascherio A. Dietary Fiber and Amyotrophic Lateral Sclerosis: Results From 5 Large Cohort Studies. American Journal Of Epidemiology 2014, 179: 1442-1449. PMID: 24816788, PMCID: PMC4051879, DOI: 10.1093/aje/kwu089.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisCohort studyALS riskFiber intakeLateral sclerosisCause of ALSLarge prospective cohort studyRisk of ALSProspective cohort studyHigh fiber intakeMedian survival timeCase-control studyLarge cohort studyProportional hazards modelCohort-specific estimatesRandom-effects modelInflammatory markersProspective studyHighest quintileALS casesDietary intakeCereal fiberSurvival timeLower riskHazards modelPredicting Hematoma Expansion After Primary Intracerebral Hemorrhage
Brouwers HB, Chang Y, Falcone GJ, Cai X, Ayres AM, Battey TW, Vashkevich A, McNamara KA, Valant V, Schwab K, Orzell SC, Bresette LM, Feske SK, Rost NS, Romero JM, Viswanathan A, Chou S, Greenberg SM, Rosand J, Goldstein JN. Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage. JAMA Neurology 2014, 71: 158-164. PMID: 24366060, PMCID: PMC4131760, DOI: 10.1001/jamaneurol.2013.5433.Peer-Reviewed Original ResearchConceptsPrimary intracerebral hemorrhageIndependent validation cohortIntracerebral hemorrhageHematoma expansionValidation cohortHigh riskPrediction scoreUrban academic medical centerBaseline ICH volumeWarfarin sodium useProspective cohort studyAcute intracerebral hemorrhageMultivariable logistic regressionTomography angiography spot signComputed tomography angiography spot signAcademic medical centerPredictors of expansionCohort studyMultivariable analysisDevelopment cohortICH volumeC-statisticClinical trialsIndividualized treatmentMAIN OUTCOME
2013
Early-Onset Alopecia and Amyotrophic Lateral Sclerosis: A Cohort Study
Fondell E, Fitzgerald KC, Falcone GJ, O'Reilly É, Ascherio A. Early-Onset Alopecia and Amyotrophic Lateral Sclerosis: A Cohort Study. American Journal Of Epidemiology 2013, 178: 1146-1149. PMID: 23942216, PMCID: PMC3783095, DOI: 10.1093/aje/kwt096.Peer-Reviewed Original ResearchConceptsAge 45 yearsEarly-onset alopeciaRisk of ALSExtensive alopeciaTAR DNA-binding protein 43DNA-binding protein 43Health Professionals FollowAmyotrophic lateral sclerosisEarly baldingProfessionals FollowCohort studyModerate alopeciaProtein 43Large cohortHigh riskLateral sclerosisUS menAlopeciaSingle nucleotide polymorphism (SNP) variantsPolymorphism variantsALSMenFurther investigationRiskBaldingPredictors of Hematoma Volume in Deep and Lobar Supratentorial Intracerebral Hemorrhage
Falcone GJ, Biffi A, Brouwers HB, Anderson CD, Battey TW, Ayres AM, Vashkevich A, Schwab K, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J. Predictors of Hematoma Volume in Deep and Lobar Supratentorial Intracerebral Hemorrhage. JAMA Neurology 2013, 70: 988-994. PMID: 23733000, PMCID: PMC3808840, DOI: 10.1001/jamaneurol.2013.98.Peer-Reviewed Original ResearchConceptsLobar intracerebral hemorrhageIntensity of anticoagulationIntracerebral hemorrhageICH volumeHematoma volumeIndependent predictorsLobar supratentorial intracerebral haemorrhageProspective cohort studyCoronary artery diseaseSupratentorial intracerebral hemorrhageMedian ICH volumePrimary ICH patientsComputed tomography scanMultivariable linear regressionAcademic medical centerIntracerebral hemorrhage volumeLobar hemorrhageAntiplatelet treatmentRadiological outcomesArtery diseaseCohort studyDeep hemorrhagesICH locationICH patientsMale sexMagnesium intake and risk of amyotrophic lateral sclerosis: Results from five large cohort studies
Fondell E, O’Reilly É, Fitzgerald KC, Falcone GJ, McCullough ML, Park Y, Kolonel LN, Ascherio A. Magnesium intake and risk of amyotrophic lateral sclerosis: Results from five large cohort studies. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2013, 14: 356-361. PMID: 23777266, PMCID: PMC3743429, DOI: 10.3109/21678421.2013.803577.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisMagnesium intakeALS riskCohort studyLateral sclerosisCases of ALSLarge prospective cohort studyProspective cohort studyDietary magnesium intakeLow magnesium intakeCase-control studyLarge cohort studyProportional hazards modelCohort-specific estimatesRandom-effects modelProspective studyHighest quintileDietary intakeProtective effectHazards modelIntakeMagnesium absorptionSclerosisHeavy metal exposureRiskIntakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: Pooled results from 5 cohort studies
Fitzgerald KC, O'Reilly ÉJ, Fondell E, Falcone GJ, McCullough ML, Park Y, Kolonel LN, Ascherio A. Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: Pooled results from 5 cohort studies. Annals Of Neurology 2013, 73: 236-245. PMID: 23362045, PMCID: PMC3608702, DOI: 10.1002/ana.23820.Peer-Reviewed Original ResearchConceptsRisk of ALSAmyotrophic lateral sclerosisNurses' Health StudyRisk ratioALS deathsVitamin CLateral sclerosisHealth StudyCancer Prevention Study II Nutrition CohortCox proportional hazards regressionMultivariate risk ratiosRetired Persons DietHealth Professionals FollowVitamin C intakeNational Death IndexProportional hazards regressionHigh dietary intakeRandom-effects methodNutrition CohortProfessionals FollowCohort studyProspective cohortC intakeDeath IndexHazards regression