2013
Investigation of the Interactions between Methadone and Elvitegravir-Cobicistat in Subjects Receiving Chronic Methadone Maintenance
Bruce RD, Winkle P, Custodio JM, Wei X, Rhee MS, Kearney BP, Ramanathan S, Friedland GH. Investigation of the Interactions between Methadone and Elvitegravir-Cobicistat in Subjects Receiving Chronic Methadone Maintenance. Antimicrobial Agents And Chemotherapy 2013, 57: 6154-6157. PMID: 24080665, PMCID: PMC3837895, DOI: 10.1128/aac.01229-13.Peer-Reviewed Original ResearchConceptsEVG/COBIBaseline valuesEffect of elvitegravirOpioid-dependence therapiesHIV-seronegative subjectsConcentration-time curveChronic methadone maintenanceDependence therapyOpioid withdrawalMethadone pharmacokineticsDosing periodMethadone maintenanceHistorical controlsPharmacodynamic studiesPharmacokinetic parametersMethadoneCobicistatElvitegravirMean areaAUCtauPharmacodynamicsCmaxSubjectsCOBISteady-state evaluationA review of pharmacological interactions between HIV or hepatitis C virus medications and opioid agonist therapy: implications and management for clinical practice
Bruce RD, Moody DE, Altice FL, Gourevitch MN, Friedland GH. A review of pharmacological interactions between HIV or hepatitis C virus medications and opioid agonist therapy: implications and management for clinical practice. Expert Review Of Clinical Pharmacology 2013, 6: 249-269. PMID: 23656339, PMCID: PMC4198941, DOI: 10.1586/ecp.13.18.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyAntiretroviral therapyDrug interactionsAgonist therapyHIV medicationsHepatitis C virus medicationsHepatitis C virus (HCV) treatmentActive antiretroviral therapyC virus treatmentPharmacodynamic drug interactionsImportant clinical consequencesReview of abstractsHCV therapyAntiretroviral agentsPharmacodynamic interactionsPharmacological interactionsHIV therapyClinical consequencesVirus treatmentClinical practiceFollowing keywordsTherapyClinical implicationsMedicationsMethadone
2006
Opioid Dependence: Rationale for and Efficacy of Existing and New Treatments
Fiellin DA, Friedland GH, Gourevitch MN. Opioid Dependence: Rationale for and Efficacy of Existing and New Treatments. Clinical Infectious Diseases 2006, 43: s173-s177. PMID: 17109303, DOI: 10.1086/508180.BooksConceptsOpioid agonist treatmentOpioid dependenceAgonist treatmentHuman immunodeficiency virus (HIV) transmissionBuprenorphine/naloxone combinationNeurobiological basisOpioid withdrawalBuprenorphine treatmentHIV infectionDecreased riskNaloxone combinationOpioid receptorsGeneral physiciansMedical disordersNew treatmentsMethadoneVirus transmissionBuprenorphineTreatmentMedicationsPatientsChronicInfectionIntracellular processesPhysiciansPharmacokinetic Drug Interactions Between Opioid Agonist Therapy and Antiretroviral Medications
Bruce RD, Altice FL, Gourevitch MN, Friedland GH. Pharmacokinetic Drug Interactions Between Opioid Agonist Therapy and Antiretroviral Medications. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2006, 41: 563-572. PMID: 16652030, DOI: 10.1097/01.qai.0000219769.89679.ec.Peer-Reviewed Original ResearchConceptsPharmacokinetic drug interactionsOpioid agonist therapyDrug interactionsAgonist therapyAntiretroviral therapyAntiretroviral medicationsImportant pharmacokinetic drug interactionsClinical case seriesImportant clinical consequencesClass of agentsHIV/AIDSPharmacokinetic interaction studyAntiretroviral agentsCase seriesOpioid dependenceHIV treatmentTreatable diseaseHIV therapyClinical consequencesFollowing keywordsMethadoneTherapyClinical implicationsLanguage articlesMedications
2004
Drug Interactions between Opioids and Antiretroviral Medications: Interaction between Methadone, LAAM, and Nelfinavir
McCance‐Katz E, Rainey PM, Smith P, Morse G, Friedland G, Gourevitch M, Jatlow P. Drug Interactions between Opioids and Antiretroviral Medications: Interaction between Methadone, LAAM, and Nelfinavir. American Journal On Addictions 2004, 13: 163-180. PMID: 15204667, DOI: 10.1080/10550490490436037.Peer-Reviewed Original ResearchConceptsDrug interactionsMetabolite exposureClinical pharmacology studiesInjection drug usersNelfinavir concentrationsOpiate medicationsOpiate therapyMethadone exposureAntiretroviral medicationsHIV outcomesDay study periodPharmacology studiesDrug usersMethadoneNelfinavirLAAMStudy periodMedicationsMinimal overall changeProtease inhibitorsExposureToxicityOverall changeAntiretroviralsOpioids
2003
The Protease Inhibitor Lopinavir-Ritonavir May Produce Opiate Withdrawal in Methadone-Maintained Patients
McCance-Katz EF, Rainey PM, Friedland G, Jatlow P. The Protease Inhibitor Lopinavir-Ritonavir May Produce Opiate Withdrawal in Methadone-Maintained Patients. Clinical Infectious Diseases 2003, 37: 476-482. PMID: 12905130, DOI: 10.1086/376907.Peer-Reviewed Original ResearchConceptsLopinavir-ritonavirMethadone metabolismSubstance abuse pharmacotherapyOpiate withdrawal symptomsInjection drug usersConcentration-time curveMethadone areaMethadone dosesHIV diseaseMethadone concentrationsOral clearancePharmacodynamic interactionsWithdrawal symptomsOpiate withdrawalClinical monitoringDrug usersSame dosageRitonavirPotent inducerPatientsMethadoneProtease inhibitorsSignificant reductionR formulationTreatment
2000
Interaction of Methadone with Didanosine and Stavudine
Rainey P, Friedland G, McCance-Katz E, Andrews L, Mitchell S, Charles C, Jatlow P. Interaction of Methadone with Didanosine and Stavudine. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 241-248. DOI: 10.1097/00042560-200007010-00008.Peer-Reviewed Original ResearchConceptsD4TMethadone therapyMore nucleoside analoguesStable methadone therapyActive antiretroviral therapyEffects of methadonePeak drug concentrationInjection drug usersInteraction of methadoneOpiate-dependent injection drug usersCurrent HAART regimensTime-concentration curveExtrapolated AUCMethadone dispositionAntiretroviral therapyHAART regimensDosing intervalTrough levelsMethadone treatmentHistorical controlsLarge dosesStudy subjectsDrug usersMethadoneDrug concentrationsInteraction of Methadone with Didanosine and Stavudine
Rainey P, Friedland G, McCanceKatz E, Andrews L, Mitchell S, Charles C, Jatlow P. Interaction of Methadone with Didanosine and Stavudine. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 241-248. PMID: 10969348, DOI: 10.1097/00126334-200007010-00007.Peer-Reviewed Original ResearchConceptsD4TMethadone therapyMore nucleoside analoguesStable methadone therapyActive antiretroviral therapyEffects of methadonePeak drug concentrationInjection drug usersInteraction of methadoneOpiate-dependent injection drug usersCurrent HAART regimensTime-concentration curveExtrapolated AUCMethadone dispositionAntiretroviral therapyHAART regimensDosing intervalTrough levelsMethadone treatmentHistorical controlsLarge dosesStudy subjectsDrug usersMethadoneDrug concentrationsInteractions between methadone and medications used to treat HIV infection: a review.
Gourevitch M, Friedland G. Interactions between methadone and medications used to treat HIV infection: a review. Annals Of Global Health 2000, 67: 429-36. PMID: 11064494.Peer-Reviewed Original ResearchConceptsMetabolic enzyme inductionAntiretroviral regimensAntiretroviral therapyHIV infectionPharmacokinetic interactionsNarcotic withdrawalPharmacologic interactionsMedication interactionsSpecific HIVPharmacologic studiesOpiate dependenceSide effectsMedicationsElectronic databasesMethadoneClinical implicationsHIVAdditional publicationsEnzyme inductionFurther studiesHuman subjectsScientific meetingsCurrent understandingRegimensPharmacotherapy