2016
The Critical Role of SENP1‐Mediated GATA2 DeSUMOylation in Graft Arteriosclerosis by Promoting Endothelial Activation
Qiu C, Wang Y, Zhu X, Song L, Zhang H, Qin L, Tellides G, Min W, Yu L. The Critical Role of SENP1‐Mediated GATA2 DeSUMOylation in Graft Arteriosclerosis by Promoting Endothelial Activation. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.165.3.Peer-Reviewed Original ResearchGraft arteriosclerosisEndothelial adhesion moleculesEC activationEndothelial activationAdhesion moleculesGA progressionNeointima formationClinical graft rejectionAorta transplantation modelEndothelial cell activationLeukocyte-endothelial adhesionConditional knockout miceDeficient graftsGraft failureGraft rejectionVasomotor dysfunctionEndothelial overexpressionEndothelial inflammationAllograft transplantationVascular occlusionEC dysfunctionTransplantation modelLeukocyte recruitmentVascular remodelingKnockout mice
2000
Human TNF Can Induce Nonspecific Inflammatory and Human Immune-Mediated Microvascular Injury of Pig Skin Xenografts in Immunodeficient Mouse Hosts
Kirkiles-Smith N, Tereb D, Kim R, McNiff J, Schechner J, Lorber M, Pober J, Tellides G. Human TNF Can Induce Nonspecific Inflammatory and Human Immune-Mediated Microvascular Injury of Pig Skin Xenografts in Immunodeficient Mouse Hosts. The Journal Of Immunology 2000, 164: 6601-6609. PMID: 10843720, DOI: 10.4049/jimmunol.164.12.6601.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAdultAnimalsCell Adhesion MoleculesDose-Response Relationship, ImmunologicDrug SynergismEndothelium, VascularGraft RejectionHistocompatibility AntigensHumansInterferon-gammaMiceMice, Inbred C57BLMice, SCIDMicrocirculationSevere Combined ImmunodeficiencySkin TransplantationSwineT-LymphocytesTransplantation, HeterologousTumor Necrosis Factor-alphaUp-RegulationConceptsHuman T-cell infiltrationPig skin xenograftsT cell infiltrationSkin xenograftsCell infiltrationHuman TNFIFN-gammaE-selectinT cell-mediated rejectionEndothelial cellsAdhesion moleculesCytokine-mediated injuryNonspecific inflammatory damagePig skin graftsCell-mediated rejectionAppropriate therapeutic targetsImmunodeficient mouse modelPorcine E-selectinEndothelial adhesion moleculesPorcine IFN-gammaClass II moleculesHuman skin allograftsMHC class IPorcine endothelial cellsImmunodeficient mouse hosts