2004
Asthma: Mechanisms of Disease Persistence and Progression
Cohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression. Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.BooksConceptsIL-13Key effector cytokineAnti-inflammatory therapyIL-13 productionProduction of chemokinesProgression of diseaseAirway fibrosisAllergic asthmaAirway remodelingEffector cytokinesEosinophilic inflammationPersistent diseaseTh2 cytokinesEpithelial damageDisease progressionInflammatory responseTh2 cellsMucus productionSmooth muscleBronchial airwaysMatrix metalloproteinasesAnimal dataAsthmaDisease persistenceInflammation
2000
Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection
Nau G, Chupp G, Emile J, Jouanguy E, Berman J, Casanova J, Young R. Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection. American Journal Of Pathology 2000, 157: 37-42. PMID: 10880373, PMCID: PMC1850209, DOI: 10.1016/s0002-9440(10)64514-2.Peer-Reviewed Original ResearchConceptsInfected lymph nodesMycobacterial infectionOsteopontin expression correlatesLymph nodesClinical outcomesDisseminated infectionExpression correlatesBacillus Calmette-Guérin (BCG) vaccineMycobacterium bovis bacillus Calmette-Guérin (BCG) vaccineCalmette-Guérin vaccineBetter clinical outcomesChronic inflammatory diseaseSevere mycobacterial infectionsInterferon gamma receptor 1OPN protein expressionRegional adenitisImmune defectsInflammatory diseasesDisease progressionInflammatory responsePatientsReceptor 1InfectionOPN expressionProtein expression