Gaëlle J. S. Talross, PhD
Associate Research Scientist, Molecular, Cellular and Developmental BiologyDownloadHi-Res Photo
About
Titles
Associate Research Scientist, Molecular, Cellular and Developmental Biology
Biography
I'm fascinated by the mysteries of how long non-coding (lnc) RNAs shape neuronal function, a key to unlocking insights into neurological disorders. Using the robust experimental toolkit inherent to the fly chemosensory systems, I investigate the complex role of lncRNAs in both neurons and behavior.
During my Ph.D. training with Dr. Joseph Gall and Dr. Nicholas Ingolia, I explored the intricate facets of lncRNAs. My discoveries include (i) distinct stable intronic sequence (sis)RNAs that influence snoRNAs' levels, crucial RNAs for ribosomal function, (ii) insights into the dual character of 7SL, and (iii) contributions to the revelation that specific lncRNAs have the capacity to encode micropeptides.
As a postdoctoral fellow under Dr. John Carlson, I've established a groundwork to use the fly chemosensory systems for probing the non-coding roles of neuronal RNA across molecular, cellular, physiological, and behavioral dimensions. My research unveils connections between RNAs, neuronal functions, and adaptive behaviors.
Appointments
Molecular, Cellular, and Developmental Biology
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- Johns Hopkins University, Biology (2018)
- BS
- University of Wisconsin, La Crosse, Biology and Biochemistry (2011)
Research
Overview
Medical Research Interests
Drosophila; Neurons; RNA, Circular; RNA, Long Noncoding
ORCID
0000-0002-4785-0606
Research at a Glance
Yale Co-Authors
Frequent collaborators of Gaëlle J. S. Talross's published research.
Publications Timeline
A big-picture view of Gaëlle J. S. Talross's research output by year.
Research Interests
Research topics Gaëlle J. S. Talross is interested in exploring.
John Carlson, PhD
Hany Dweck
Shimaa Ebrahim
Yichen Luo
Joshua Gendron, PhD
18Publications
125Citations
Drosophila
RNA, Long Noncoding
Neurons
Publications
2024
Function and evolution of Ir52 receptors in mate detection in Drosophila
Luo Y, Talross G, Carlson J. Function and evolution of Ir52 receptors in mate detection in Drosophila. Current Biology 2024 PMID: 39471807, DOI: 10.1016/j.cub.2024.10.001.Peer-Reviewed Original ResearchAltmetricConceptsMating partnersCluster of genesPotential mating partnersSexually dimorphic neuronsCourtship behaviorEvolutionary timeMate detectionExpression systemFly legFruit flyFly speciesSpeciesBiological problemsTaste neuronsMatingPheromone extractsFliesReceptorsDrosophilaCourtshipGenesNeuronsPheromoneCircuit mappingExpressionMosquito taste responses to human and floral cues guide biting and feeding
Baik L, Talross G, Gray S, Pattisam H, Peterson T, Nidetz J, Hol F, Carlson J. Mosquito taste responses to human and floral cues guide biting and feeding. Nature 2024, 635: 639-646. PMID: 39415007, PMCID: PMC11578787, DOI: 10.1038/s41586-024-08047-y.Peer-Reviewed Original ResearchAltmetricConceptsResponse to sugarFloral cuesCoding capacityControl mosquito vectorsEgg layingTaste sensillaTranscriptome profilingTaste organsNeuronal repertoireBiting behaviorInsect behaviorBitter compoundsInvasive diseaseTaste receptorsTaste systemTasteTaste responsesMosquito vectorsStop signalTaste stimuliFeedingSite waterLabellumExcitatory responsesNectarSugar detection in 3D: Structure of an insect gustatory receptor
Talross G, Carlson J. Sugar detection in 3D: Structure of an insect gustatory receptor. Cell Reports 2024, 43: 114166. PMID: 38691457, DOI: 10.1016/j.celrep.2024.114166.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsExitron splicing of odor receptor genes in Drosophila
Shang X, Talross G, Carlson J. Exitron splicing of odor receptor genes in Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2320277121. PMID: 38507450, PMCID: PMC10990081, DOI: 10.1073/pnas.2320277121.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExitron splicingOdorant receptor genesCases of alternative splicingCanonical open reading framesExpression of odorant receptor genesFunction of olfactory systemReceptor geneProtein-coding exonsOpen reading frameAlternative splicing eventsOlfactory receptor neuronsAlternative polyadenylationReading frameExon-intronEncode proteinsSplicing eventsAlternative splicingNon-coding RNAsStable proteinsPheromone receptorsReceptor neuronsOptogenetic activationPheromone stimulationSplicingNeuronal activity
2023
The rich non-coding RNA landscape of the Drosophila antenna
Talross G, Carlson J. The rich non-coding RNA landscape of the Drosophila antenna. Cell Reports 2023, 42: 112482. PMID: 37167060, PMCID: PMC10431215, DOI: 10.1016/j.celrep.2023.112482.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDrosophila antennaPheromone-sensing neuronsLong non-coding RNAsNon-coding RNAsDrosophila olfactory systemRole of lncRNAsMultiple complex behaviorsRNA landscapeOlfactory receptor neuronsNeuronal lncRNAsNeural developmentLncRNAsReceptor neuronsModel systemPheromonal responsesOlfactory systemCritical roleNeuron mapNervous systemRNACombination of lncRNAsSpeciationNeuronsRole
2022
Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii
Wang W, Dweck H, Talross G, Zaidi A, Gendron J, Carlson J. Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii. ELife 2022, 11: e81703. PMID: 36398882, PMCID: PMC9674340, DOI: 10.7554/elife.81703.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEgg-laying preferenceTaste organsAgricultural pestsDrosophila suzukiiChannel genesStiff substratesDrosophilaTaste sensillaReceptor geneMechanosensory cuesFruit sugarsGenesMechanosensationTaste sensationBitter taste sensationSpeciesEggsSweet taste sensationMajor subsetSuzukiiPestsSugarsElectrophysiological responsesWeak preferenceVariety of changesIr56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila
Dweck HKM, Talross GJS, Luo Y, Ebrahim SAM, Carlson JR. Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila. Current Biology 2022, 32: 1776-1787.e4. PMID: 35294865, PMCID: PMC9050924, DOI: 10.1016/j.cub.2022.02.063.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSalt tasteBitter-sensing neuronsStop codonLoss of functionNumber of speciesIonotropic receptorsIonotropic receptor familyN-terminal regionReceptor familyNeuronsDrosophila speciesPremature stop codonTaste modalitiesAncient functionGR familySalt responseSense codonsMolecular basisAtypical memberSalt detectionModalitiesCodonSensory modalitiesDrosophilaBehavioral responses
2021
Stable lariats bearing a snoRNA (slb-snoRNA) in eukaryotic cells: A level of regulation for guide RNAs.
Talross GJS, Deryusheva S, Gall JG. Stable lariats bearing a snoRNA (slb-snoRNA) in eukaryotic cells: A level of regulation for guide RNAs. Proc Natl Acad Sci U S A 2021, 118 PMID: 34725166, DOI: 10.1073/pnas.2114156118.Peer-Reviewed Original ResearchSnoRNA guide activities: real and ambiguous.
Deryusheva S, Talross GJS, Gall JG. SnoRNA guide activities: real and ambiguous. RNA 2021, 27: 1363-1373. PMID: 34385348, DOI: 10.1261/rna.078916.121.Peer-Reviewed Original ResearchSight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila
Ebrahim SAM, Talross GJS, Carlson JR. Sight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila. Nature Communications 2021, 12: 2453. PMID: 33907186, PMCID: PMC8079388, DOI: 10.1038/s41467-021-22712-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptation, PhysiologicalAnimalsAnimals, Genetically ModifiedBeta-Carotene 15,15'-MonooxygenaseCarnivoryDrosophilaDrosophila melanogasterDrosophila ProteinsDrosophila simulansFemaleFertilityGene Expression RegulationMaleNeuronsPattern Recognition, VisualReceptors, Ionotropic GlutamateReceptors, OdorantSexual Behavior, AnimalWaspsConceptsWasp speciesParasitoid waspsParasitoid wasp speciesInsect speciesAdult DrosophilaInsect worldMating behaviorMutational analysisGene expressionFemale fliesWaspsGenesDrosophilaSpeciesFliesDramatic upregulationDefensive responsesWidespread deathVisual circuitsInsectsMicropeptidesBehavioral responsesNervous systemHundreds of thousandsUnexpected responses
Academic Achievements & Community Involvement
honor K99 fellowship
National AwardNIDCDDetails02/05/2024United Stateshonor Joan and Tom Steitz RNA Fellowship
Yale School of Medicine AwardYale Center for RNA Science and MedecineDetails03/06/2023United Stateshonor F32 fellowship
National AwardNIDCDDetails09/01/2022United Stateshonor DuPont Teaching Award
Regional AwardJohns Hopkins UniversityDetails05/10/2013United Stateshonor Outstanding senior of the year in Cellular and Molecular Biology Award
Regional AwardUniversity of Wisconsin, La CrosseDetails05/16/2011United States