2011
Environmental and Genetic Stressors and the Unfolded Protein Response in Exocrine Pancreatic Function – A Hypothesis
Pandol SJ, Gorelick FS, Lugea A. Environmental and Genetic Stressors and the Unfolded Protein Response in Exocrine Pancreatic Function – A Hypothesis. Frontiers In Physiology 2011, 2: 8. PMID: 21483727, PMCID: PMC3070477, DOI: 10.3389/fphys.2011.00008.Peer-Reviewed Original ResearchProtein responseER stressProtein synthetic machineryUnfolded protein responseDigestive enzymesProtein synthetic capacityRecent findingsAdaptive UPREndoplasmic reticulum stressGenetic stressorsSynthetic machineryMammalian organsEnvironmental stressorsProtein synthesisKey pathwaysUPRReticulum stressExocrine cellsExocrine pancreasSynthetic capacityEnzymePathwayPathologic pathwaysStressorsMachinery
2010
Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis
Pandol SJ, Gorelick FS, Gerloff A, Lugea A. Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis. Digestive Diseases 2010, 28: 776-782. PMID: 21525762, PMCID: PMC3211518, DOI: 10.1159/000327212.Peer-Reviewed Original ResearchConceptsX-box binding protein 1Alcohol abuseChronic pancreatitisEthanol feedingUnfolded protein responseER stressSignificant pathological responseAcinar cellsAfrican American ethnicityEndoplasmic reticulum stressPancreatic manifestationAlcoholic pancreatitisAdaptive unfolded protein responseMinority of individualsChronic inflammationMost individualsPathological responseCommon causePancreatic diseaseApparent diseasePancreatitisBinding protein 1Heavy drinkersExocrine pancreasPancreas
2009
T1834 Role of XBP1 in the Protective Unfolded Protein Response to Limit Chronic Ethanol-Induced Endoplasmic Reticulum Stress and Damage in the Pancreas
Lugea A, Gukovsky I, French S, Gorelick F, Pandol S. T1834 Role of XBP1 in the Protective Unfolded Protein Response to Limit Chronic Ethanol-Induced Endoplasmic Reticulum Stress and Damage in the Pancreas. Gastroenterology 2009, 136: a-589. DOI: 10.1016/s0016-5085(09)62715-3.Peer-Reviewed Original Research