2006
Phospholipase D1 corrects impaired βAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons
Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Phospholipase D1 corrects impaired βAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 1936-1940. PMID: 16449385, PMCID: PMC1413666, DOI: 10.1073/pnas.0510710103.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkOverexpression of PLD1Mutant neuronsPhospholipase D1Beta-amyloid precursor proteinIntracellular traffickingPS1-deficient cellsPLD enzymatic activityTherapeutic targetNeuronal functionPS1 mutationsOverexpression of WTBetaAPPPrecursor proteinMutant cellsSubcellular localizationNeurite outgrowthPLD1 activitySurface deliveryNeuronsOutgrowth capacityCellsTraffickingEnzymatic activityOverexpression
1996
Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells.
Matovcik LM, Maranto AR, Soroka CJ, Gorelick FS, Smith J, Goldenring JR. Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells. Journal Of Histochemistry & Cytochemistry 1996, 44: 1243-1250. PMID: 8918899, DOI: 10.1177/44.11.8918899.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium ChannelsCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesCell PolarityDigestive SystemFluorescent Antibody Technique, IndirectInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsIntestinal MucosaMaleRabbitsRatsRats, Sprague-DawleyReceptors, Cytoplasmic and NuclearConceptsType 3 InsP3 receptorCaM kinase IICalmodulin-dependent protein kinase IIKinase IIProtein kinase IIInsP3 receptorPotential phosphorylation sitesCalcium/calmodulin-dependent protein kinase IIType 3 inositolPhosphorylation sitesApical domainSubcellular localizationCytoskeletal domainTrisphosphate receptorPancreatic acinar cellsImmunofluorescence microscopyPhysiologic substratesGastrointestinal tissuesRabbit gastric glandsF-actin domainsGastrointestinal mucosal cellsIntestinal enterocytesApical regionAcinar cellsInositol