2009
Reducing Extracellular pH Sensitizes the Acinar Cell to Secretagogue-Induced Pancreatitis Responses in Rats
Bhoomagoud M, Jung T, Atladottir J, Kolodecik TR, Shugrue C, Chaudhuri A, Thrower EC, Gorelick FS. Reducing Extracellular pH Sensitizes the Acinar Cell to Secretagogue-Induced Pancreatitis Responses in Rats. Gastroenterology 2009, 137: 1083-1092. PMID: 19454288, PMCID: PMC2736307, DOI: 10.1053/j.gastro.2009.05.041.Peer-Reviewed Original ResearchConceptsAcinar cellsAcute pancreatitisPancreatic acinar cellsSecretagogue-induced pancreatitisAcid loadAcid challengeAcute acid loadKey early eventPancreatic edemaClinical studiesCell injuryPancreatitisAmylase secretionIsolated aciniAbstractTextPhe effectTrypsinogen activationInjuryPancreatitis responsesZymogen activationAIMSEarly eventsRatsActivationRelevant concentrations
2004
Acute pancreatitis
Nagar AB, Gorelick FS. Acute pancreatitis. Current Opinion In Gastroenterology 2004, 20: 439-443. PMID: 15689676, DOI: 10.1097/00001574-200409000-00004.Peer-Reviewed Original ResearchAcute pancreatitisExperimental acute pancreatitisNeurokinin-1 receptor antagonistPostendoscopic retrograde cholangiopancreatography pancreatitisTranscription factor nuclear factor-kappaBPancreatic duct stentingPrimary sensory neuronsUse of cytokinesHigh-risk peopleCyclo-oxygenase-2Use of diclofenacRegulation of inflammationFinal common pathwayNuclear factor-kappaBEarly eventsDuct stentingLung injuryInflammatory inhibitorPancreatic inflammationCholangiopancreatography pancreatitisCytokine responsesPathologic activationSignificant morbidityMet-RANTESReceptor antagonist