2024
IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation.
Mullan C, Summer L, Lopez-Giraldez F, Tobiasova Z, Manes T, Yasothan S, Song G, Jane-Wit D, Saltzman W, Pober J. IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation. The Journal Of Immunology 2024, 213: 1338-1348. PMID: 39302113, PMCID: PMC11493510, DOI: 10.4049/jimmunol.2400331.Peer-Reviewed Original ResearchIL-15Surface expressionIL-1BIL-15 transcriptsEndothelial cellsCD8 T cell activationExpression of IL-15EC surface expressionIL-15 transpresentationComplement activationGraft endothelial cellsActivity of CTLT cell activationIL-15 mRNAEndothelial surface expressionAbsence of complement activationCultured human endothelial cellsIL-1-mediated activationIL-15RAProtein translationAllograft rejectionRNA polymerase II-mediated transcriptionHuman endothelial cellsSuppression of protein translation
2018
Interferon-γ converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1
Liu R, Merola J, Manes TD, Qin L, Tietjen GT, López-Giráldez F, Broecker V, Fang C, Xie C, Chen PM, Kirkiles-Smith NC, Jane-Wit D, Pober JS. Interferon-γ converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1. JCI Insight 2018, 3: e97881. PMID: 29515027, PMCID: PMC5922286, DOI: 10.1172/jci.insight.97881.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsAnimalsAntigen PresentationCell CommunicationCells, CulturedDisease Models, AnimalEndothelial CellsEndothelium, VascularFemaleGraft RejectionHealthy VolunteersHuman Umbilical Vein Endothelial CellsHumansIndoleamine-Pyrrole 2,3,-DioxygenaseInterferon-gammaIsoantigensMice, SCIDMicrovesselsPericytesPrimary Cell CultureRNA, Small InterferingSkinSkin TransplantationT-Lymphocytes, CytotoxicTransplantation ChimeraTransplantation, HomologousTryptophanConceptsInduction of indoleamineHuman pericytesEndothelial cellsAllograft rejectionTryptophan depletionT cellsAcute T cell-mediated rejectionT cell-mediated rejectionEffector memory T cellsDioxygenase 1Early acute rejectionCell-mediated rejectionSkin allograft rejectionAlloreactive T cellsHuman renal allograftsMemory T cellsRole of ECsContribution of pericytesAcute rejectionRenal allograftsImmunoregulatory effectsImmunosuppressive propertiesHuman allograftsMouse modelMicrovascular pericytes