2019
Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?
de Araujo C, Swardfager W, Zugman A, Cogo-Moreira H, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, Mansur R, Hoexter M, Picon F, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence? CNS Spectrums 2019, 25: 790-796. PMID: 31845634, DOI: 10.1017/s1092852919001688.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBiomarkersBrainBrain-Derived Neurotrophic FactorChildFemaleGenotypeHumansMagnetic Resonance ImagingMaleMental DisordersPolymorphism, Single NucleotideConceptsSerum BDNF concentrationsBrain-derived neurotrophic factorBDNF concentrationsBDNF genotypeCortical thicknessPsychiatric disordersSerum brain-derived neurotrophic factor (BDNF) concentrationsBrain-derived neurotrophic factor concentrationSubcortical volumesMental disordersWell-Being Behavior AssessmentBrain structuresBDNF serum concentrationsNeurotrophic factor concentrationsPeripheral blood concentrationsHigh Risk Cohort StudyLate childhoodAdult psychiatric disordersLarge independent samplesCohort studyNeurotrophic factorCortical maturationSerum concentrationsBlood concentrationsMet carriers
2017
Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence
de Araujo C, Zugman A, Swardfager W, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, de Moura L, Del Aquilla M, Picon F, Amaro E, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. Journal Of Psychiatric Research 2017, 98: 51-58. PMID: 29288952, DOI: 10.1016/j.jpsychires.2017.12.008.Peer-Reviewed Original ResearchMeSH KeywordsBrain-Derived Neurotrophic FactorBrazilCerebral CortexChildChild DevelopmentCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleMental DisordersPolymorphism, Single NucleotideConceptsPsychiatric disordersVal66Met polymorphismCortical thicknessBrain-derived neurotrophic factor (BDNF) Val66Met polymorphismRegional structural brain changesNeurotrophic factor Val66Met polymorphismPrefrontal cortexStructural brain changesLateral temporal cortexEffect of Val66MetBilateral prefrontal cortexVal66Met effectsWindow of vulnerabilityCortical maturationBrain changesOccipital lobeMet carriersAtypical neurodevelopmentMRI scansPsychiatric diagnosisTemporal cortexDiagnosis interactionVal66MetNeuropsychiatric disordersBrain morphology
2016
Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology
Mansur R, Cunha G, Asevedo E, Zugman A, Zeni-Graiff M, Rios A, Sethi S, Maurya P, Levandowski M, Gadelha A, Pan P, Stertz L, Belangero S, Anna M, Teixeira A, Mari J, Rohde L, Miguel E, McIntyre R, Grassi-Oliveira R, Bressan R, Brietzke E. Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology. PLOS ONE 2016, 11: e0160455. PMID: 27489945, PMCID: PMC4973983, DOI: 10.1371/journal.pone.0160455.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersBrain-Derived Neurotrophic FactorChildCross-Sectional StudiesFemaleHumansInterleukin-6MaleMental DisordersMental HealthSocioeconomic FactorsStress, PsychologicalThiobarbituric Acid Reactive SubstancesConceptsBrain-derived neurotrophic factorThiobarbituric acid reactive substancesMental health problemsInterleukin-6Serum levelsHealth problemsSocioeconomic disadvantagePeripheral biomarkersSerum biomarkersOxidative stress markersAcid reactive substancesCross-sectional designChild Behavior Checklist DSMNeurotrophic factorHigher socioeconomic disadvantageSocio-demographic characteristicsBiomarker levelsNeurotrophic proteinsDomains of psychopathologyStress markersSpecific SubscaleCumulative risk modelBiomarkersMultiple biological systemsPathological neurodevelopment