2016
DBS for Obesity
Franco R, Fonoff E, Alvarenga P, Lopes A, Miguel E, Teixeira M, Damiani D, Hamani C. DBS for Obesity. Brain Sciences 2016, 6: 21. PMID: 27438859, PMCID: PMC5039450, DOI: 10.3390/brainsci6030021.Peer-Reviewed Original ResearchDeep brain stimulationMorbid obesityUse of DBSDifferent brain targetsNon-negligible incidenceNeurosurgical modalityNumerous comorbiditiesRefractory obesityBariatric surgeryOperative failureEarly mortalitySurgical resultsBrain targetsPrevalent disorderBrain stimulationSide effectsObesityNeuropsychiatric disordersDisordersComorbiditiesPatientsSurgeryBehavioral approachMortalityIncidence
2015
Gamma knife surgery
Lopes A, Batistuzzo M, Gentil A, Hoexter M, Miguel E. Gamma knife surgery. 2015, 369-383. DOI: 10.1002/9781118801086.ch20.Peer-Reviewed Original ResearchSevere adverse eventsGamma Knife surgeryGamma knife radiosurgeryDeep brain stimulationAdverse eventsBrain cystsCase seriesDecreased incidenceObsessive-compulsive disorderSymptom improvementInternal capsuleKnife radiosurgeryAblative proceduresAnterior limbPsychiatric disordersBrain stimulationMajority of studiesRadiosurgical techniquesWhite matter tissueDisordersPatientsSurgeryLesionsRadiosurgeryIncidence
2014
Hoarding symptoms and prediction of poor response to limbic system surgery for treatment-refractory obsessive-compulsive disorder.
Gentil AF, Lopes AC, Dougherty DD, Rück C, Mataix-Cols D, Lukacs TL, Canteras MM, Eskandar EN, Larsson KJ, Hoexter MQ, Batistuzzo MC, Greenberg BD, Miguel EC. Hoarding symptoms and prediction of poor response to limbic system surgery for treatment-refractory obsessive-compulsive disorder. Journal Of Neurosurgery 2014, 121: 123-30. PMID: 24702323, DOI: 10.3171/2014.2.jns131423.Peer-Reviewed Original ResearchConceptsLimbic system surgeryClinical outcomesWorse responseMean Y-BOCS scoreTreatment-refractory obsessive-compulsive disorderSymptom dimensionsPreoperative symptom severityWorse clinical outcomesTreatment-refractory patientsYale-Brown Obsessive Compulsive ScaleY-BOCS scoresSymptom Checklist scoresHoarding dimensionObsessive Compulsive ScaleSurgery needObsessive-compulsive disorderSurgical modalitiesAblative surgeryPoor responseWorse outcomesTreatment outcomesDimensional Yale-Brown Obsessive Compulsive ScaleYBOCS scoresPatientsSurgery
2010
Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder
Gouvea F, Lopes A, Greenberg B, Canteras M, Taub A, Mathis M, Miguel E. Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder. Stereotactic And Functional Neurosurgery 2010, 88: 177-182. PMID: 20431329, DOI: 10.1159/000313870.Peer-Reviewed Original ResearchConceptsRefractory obsessive-compulsive disorderGamma ventral capsulotomyClinical responseSham surgeryObsessive-compulsive disorderSurgical techniquePsychopathological changesRadiosurgical proceduresRemarkable ameliorationActive interventionCompulsive disorderDisordersActive procedureCapsulotomySurgeryShamRadiosurgery
2009
Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study
Lopes A, Greenberg B, Norén G, Canteras M, Busatto G, de Mathis M, Taub A, D'Alcante C, Hoexter M, Gouvea F, Cecconi J, Gentil A, Ferrão Y, Fuentes D, de Castro C, Leite C, Salvajoli J, Duran F, Rasmussen S, Miguel E. Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study. Journal Of Neuropsychiatry 2009, 21: 381-392. PMID: 19996246, DOI: 10.1176/jnp.2009.21.4.381.Peer-Reviewed Original ResearchConceptsResistant obsessive-compulsive disorderRefractory OCD patientsAdverse effectsPilot prospective studyObsessive-compulsive disorder patientsAdverse eventsProspective studyObsessive-compulsive disorderStereotactic radiosurgeryDepressive symptomsDisorder patientsSide effectsConventional treatmentCapsulotomyTherapeutic promisePatientsOCD patientsTreatmentSurgeryRadiosurgerySymptomsMonths