2023
Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response
McLaughlin N, Magnotti J, Banks G, Nanda P, Hoexter M, Lopes A, Batistuzzo M, Asaad W, Stewart C, Paulo D, Noren G, Greenberg B, Malloy P, Salloway S, Correia S, Pathak Y, Sheehan J, Marsland R, Gorgulho A, De Salles A, Miguel E, Rasmussen S, Sheth S. Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response. Translational Psychiatry 2023, 13: 134. PMID: 37185805, PMCID: PMC10130137, DOI: 10.1038/s41398-023-02425-2.Peer-Reviewed Original ResearchConceptsY-BOCS reductionObsessive-compulsive disorderGamma knife capsulotomyLesion sizeRefractory obsessive-compulsive disorderOverall lesion volumeIntractable obsessive-compulsive disorderLesion-symptom mappingVoxel-wise lesion-symptom mappingClinical improvementClinical responseWhite matter pathwaysClinical outcomesFull respondersConventional therapyInternal capsuleLesion characteristicsLesion volumeAnterior limbEffective treatmentLesion locationLesion occurrenceCoronal planeSize/locationPatients
2021
Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder
Shephard E, Stern E, van den Heuvel O, Costa D, Batistuzzo M, Godoy P, Lopes A, Brunoni A, Hoexter M, Shavitt R, Reddy Y, Lochner C, Stein D, Simpson H, Miguel E. Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder. Molecular Psychiatry 2021, 26: 4583-4604. PMID: 33414496, PMCID: PMC8260628, DOI: 10.1038/s41380-020-01007-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCognitive neuroscienceNeurobiological alterationsMental health researchClinical profileFuture researchCase vignettesPsychiatric symptomsNeuromodulatory treatmentDifferent clinical profilesNeuroscienceEffective treatmentDisordersResearchBehavioralVignettesFindingsHealth researchTreatmentDysfunctionSymptomsPhenotypic expressionImportant limitationsTaxonomyPatients
2019
Obsessive–compulsive disorder
Stein D, Costa D, Lochner C, Miguel E, Reddy Y, Shavitt R, van den Heuvel O, Simpson H. Obsessive–compulsive disorder. Nature Reviews Disease Primers 2019, 5: 52. PMID: 31371720, PMCID: PMC7370844, DOI: 10.1038/s41572-019-0102-3.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSimilar symptom dimensionsExtent of comorbiditySpecific brain circuitsGroup of conditionsTranslational Neuroscience ApproachCognitive behavioral therapyIntractable symptomsReuptake inhibitorsClinical outcomesChronic conditionsGlobal disabilityEffective treatmentInternational ClassificationGlobal mental healthRelated disordersMental disordersNeuropsychiatric disordersRepetitive stereotyped behaviorsBrain circuitsIndividualized assessmentMental healthNeurobiological mechanismsStatistical ManualHomogenous disorder