2024
Association Between Juvenile Psychotic Experiences and Problematic Gaming
Fernandes A, Biokino R, Miguel A, Machado V, Koga G, Fonseca L, Pan P, Roza T, Salum G, Passos I, Rohde L, Miguel E, Ziebold C, Gadelha A. Association Between Juvenile Psychotic Experiences and Problematic Gaming. Schizophrenia Bulletin Open 2024, 5: sgae021. PMID: 39296676, PMCID: PMC11408271, DOI: 10.1093/schizbullopen/sgae021.Peer-Reviewed Original ResearchPsychotic experiencesProblematic gamingGame addictionDSM-IVBrazilian community sampleDSM-IV diagnosisMental health conditionsCommunity samplePsychiatric disordersCross-sectional subsamplePsychiatric conditionsAssociated with significant adverse outcomesReport PEBehavioral pathwaysLevels of PESignificant adverse outcomesAssociated with PEPE scoresSociodemographic variablesAdverse outcomesBrazilian cohortDisordersParticipantsHealth conditionsLinear regression analysisIs waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample
Bado P, Salum G, Rohde L, Gadelha A, Pan P, Miguel E, Tripp G, Furukawa E. Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample. JCPP Advances 2024, 4: e12231. PMID: 38827985, PMCID: PMC11143955, DOI: 10.1002/jcv2.12231.Peer-Reviewed Original ResearchDelayed rewardsPsychiatric conditionsPresence of psychiatric disordersLife outcomesBaseline task performanceImpulsive choicePositive long-term outcomesImmediate rewardsPsychiatric disordersTask performanceADHDResults ChildrenRewardChildren's preferencesStronger preferenceSchool-based cohortDisordersLongitudinal outcomesCohort sampleFunctional outcomesChildrenCohort of Brazilian childrenBrazilian childrenPsychopathologyDiverse populationsAn evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchConceptsYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive disorderCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual-patient data meta-analysisPosttreatment scoresEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusIndividual participant data meta-analysisSystematic reviewDisordersData meta-analysisPosttreatmentRemission definitionsImpressive improvementPerinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology
Leusin F, Damiano R, Mendes L, Hoffmann M, Manfro A, Pan P, Gadelha A, de Jesus Mari J, Manfro G, Miguel E, Rohde L, Bressan R, Salum G. Perinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology. European Child & Adolescent Psychiatry 2024, 33: 3571-3581. PMID: 38519607, DOI: 10.1007/s00787-024-02402-0.Peer-Reviewed Original ResearchMental disordersPsychiatric disordersCo-occurrence of mental disordersPresence of mental disordersDomains of psychopathologyYears of age childrenModel psychiatric disordersPsychiatric disorder diagnosisOverall psychopathologyBifactor modelDisorder diagnosisPsychopathologyBehavioral assessmentP-factorEarly environmentLow level of maternal educationLevel of maternal educationLow socioeconomic statusDisordersNeonatal factorsPrimary caregiversAge childrenAssociated with male sexSocioeconomic statusMaternal educationChapter 21 Gamma Knife for psychiatric indications
Lopes A, de Arruda I, Batistuzzo M, Gorgulho A, de Salles A, Miguel E. Chapter 21 Gamma Knife for psychiatric indications. 2024, 495-517. DOI: 10.1016/b978-0-443-18496-3.00021-5.Peer-Reviewed Original ResearchAnorexia nervosaObsessive-compulsive disorder patientsTreatment of psychiatric disordersAnterior limb of internal capsuleObsessive-compulsive disorderVentral anterior limbGamma KnifeGK radiosurgeryMajor depressionDisorder patientsPsychiatric disordersPsychiatric indicationsNervosaDepressionInternal capsuleSurgical modalitiesAdverse eventsDisordersAnorexiaRadiosurgeryWeight gainManiaPsychiatryBrain cystsComplicationsSocial skills in patients with obsessive-compulsive disorder before and after treatment.
da Silva F, Batistuzzo M, Diniz J, D'Alcante C, Timpano K, Shavitt R, Miguel E, Hoexter M. Social skills in patients with obsessive-compulsive disorder before and after treatment. Brazilian Journal Of Psychiatry 2024 PMID: 38875529, DOI: 10.47626/1516-4446-2024-3577.Peer-Reviewed Original ResearchObsessive-compulsive disorderObsessive-compulsive disorder symptomatologySocial skillsIllness durationControl participantsSeverity of obsessive-compulsive disorderObsessive-compulsive disorder severityObsessive-compulsive disorder symptomsSS total scoreScores compared to controlsOCD symptomatologyGroup differencesIllness onsetPredictors of SSTotal scoreCourse of treatmentSymptomatologyTreatment investigationsSS performanceTreatment effectsIllnessDisordersTreatment-naive patientsSkillsFollow-up period
2023
Depression in mothers at childhood: Direct and indirect association with problematic gaming in late adolescence/young adulthood
Roza T, Rabelo-da-Ponte F, Spritzer D, Hoffmann M, Massuda R, Salum G, Miguel E, Rohde L, Pan P, Kessler F, Gadelha A, Passos I. Depression in mothers at childhood: Direct and indirect association with problematic gaming in late adolescence/young adulthood. Journal Of Psychiatric Research 2023, 159: 14-21. PMID: 36652752, DOI: 10.1016/j.jpsychires.2023.01.022.Peer-Reviewed Original ResearchConceptsAdolescence/young adulthoodMothers' depressionLate adolescence/young adulthoodRisk factorsSchool-based cohortYoung adulthoodMultiple confounding factorsLogistic regression modelsInverse probability weightsConfounding factorsExternalizing disordersInternalizing disordersDepressionPotential roleDisordersChildhoodMediatorsRegression modelsMothersSexAdulthoodInternalizing psychopathologySignificant mediatorMediation analysisAssociation
2022
Co-Occurring Obsessive–Compulsive Disorder and Compulsive Sexual Behavior: Clinical Features and Psychiatric Comorbidities
Snaychuk L, Ferrão Y, Fontenelle L, Miguel E, de Mathis M, Scanavino M, Kim H. Co-Occurring Obsessive–Compulsive Disorder and Compulsive Sexual Behavior: Clinical Features and Psychiatric Comorbidities. Archives Of Sexual Behavior 2022, 51: 4111-4123. PMID: 36066680, DOI: 10.1007/s10508-022-02412-6.Peer-Reviewed Original ResearchConceptsCo-occurring obsessive-compulsive disorderObsessive-compulsive disorderPsychiatric comorbidityCompulsive sexual behaviorBinary logistic regression analysisComorbid obsessive-compulsive disorderGreater psychiatric comorbidityLogistic regression analysisComplex treatment needsSexual behaviorClinical characteristicsClinical factorsClinical featuresStandardized self-report measuresComorbiditiesControl disordersTreatment needsPsychiatric conditionsDisordersRegression analysisPreliminary evidenceSelf-report measuresCurrent studySemi-structured interviewsParticipantsLatency to treatment seeking in patients with obsessive-compulsive disorder: Results from a large multicenter clinical sample
Costa D, de Campos A, Pereira C, Torres A, Dos Santos A, Requena G, Ferrão Y, do Rosário M, Miguel E, Simpson H, Shavitt R, Diniz J. Latency to treatment seeking in patients with obsessive-compulsive disorder: Results from a large multicenter clinical sample. Psychiatry Research 2022, 312: 114567. PMID: 35490573, DOI: 10.1016/j.psychres.2022.114567.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEarly onsetOne-thirdCross-sectional studyInterval-censored survival modelClinical characteristicsOlder patientsSymptom awarenessPatientsNeuropsychiatric disordersSymptomsOlder ageOCD patientsContamination/Clinical samplesDisordersAggression symptomsOCD symptomsMore yearsTreatmentSurvival modelsOnsetYearsFull-time employmentComorbiditiesObsessive-Compulsive Disorder Treatment Based on Neurocircuits
Shephard E, Stern E, Miguel E. Obsessive-Compulsive Disorder Treatment Based on Neurocircuits. Psychiatric Annals 2022, 52: 152-156. DOI: 10.3928/00485713-20220317-01.Peer-Reviewed Original ResearchObsessive-compulsive disorderNew treatment approachesObsessive-compulsive disorder (OCD) treatmentClinical profileIndividual patientsGlobal burdenNeurocognitive alterationsPsychiatric disordersPsychiatric treatmentTreatment approachesDisorder treatmentPsychiatric conditionsClinical useSpecific neurocircuitsUnderlying neurobiological basisModels of OCDNeurobiological basisTreatmentNeurocircuitsDisordersPatientsThe Phenomenology of Obsessive–Compulsive Symptoms in Tourette Syndrome
Ferrão Y, de Alvarenga P, Hounie A, de Mathis M, Farhat L, do Rosário M, Miguel E. The Phenomenology of Obsessive–Compulsive Symptoms in Tourette Syndrome. 2022, 45-64. DOI: 10.1093/med/9780197543214.003.0004.Peer-Reviewed Original ResearchTourette syndromeObsessive-compulsive disorderObsessive-compulsive symptomsComorbid obsessive-compulsive disorderPost-traumatic stress disorderAttention-deficit/hyperactivity disorderPsychiatric comorbidityBasal gangliaBehavioral comorbiditiesSeparation anxiety disorderTreatment approachesClinical practiceComorbid diagnosesSymptom presentationComorbiditiesSimple phobiaStress disorderAnxiety disordersHyperactivity disorderSymptomsDisordersGenetic vulnerabilityBehavioral problemsSyndromeNeurocircuit models of obsessive-compulsive disorder: limitations and future directions for research
Shephard E, Batistuzzo M, Hoexter M, Stern E, Zuccolo P, Ogawa C, Silva R, Brunoni A, Costa D, Doretto V, Saraiva L, Cappi C, Shavitt R, Simpson H, van den Heuvel O, Miguel E. Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research. Brazilian Journal Of Psychiatry 2022, 44: 187-200. PMID: 35617698, PMCID: PMC9041967, DOI: 10.1590/1516-4446-2020-1709.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCourse of OCDCognitive mechanismsCommon psychiatric conditionsSpecific neurocircuitsCognitive functionNeurocognitive functionPsychiatric conditionsFuture researchComplexity of brainFuture directionsDisordersCurrent reviewNeuroscienceNeurocircuitsCompulsionResearchSymptomatologyObsessionExperiences of patientsExperienceImportant limitationsPresentationBetter understandingBrainPost-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study
Damiano R, Caruso M, Cincoto A, de Almeida Rocca C, de Pádua Serafim A, Bacchi P, Guedes B, Brunoni A, Pan P, Nitrini R, Beach S, Fricchione G, Busatto G, Miguel E, Forlenza O, Group H. Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study. General Hospital Psychiatry 2022, 75: 38-45. PMID: 35134702, PMCID: PMC8734055, DOI: 10.1016/j.genhosppsych.2022.01.002.Peer-Reviewed Original ResearchConceptsCognitive morbidityCognitive outcomesAnxiety disordersPost-traumatic stress disorderRelevant psychosocial variablesCognitive batteryMemory declineStructured psychiatric interviewStress disorderPsychosocial variablesStandardized measuresPsychosocial stressorsPsychometric testsCognitive impairmentPsychiatric interviewSevere formPreliminary findingsSARS-CoV-2 infectionCohort of survivorsLong-term outcomesAcute-phase diseaseBrazilian cohort studyCOVID-19DisordersDepression
2021
Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study
Ziebold C, Evans-Lacko S, Andrade M, Hoffmann M, Fonseca L, Barbosa M, Pan P, Miguel E, Bressan R, Rohde L, Salum G, Schafer J, de Jesus Mari J, Gadelha A. Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study. European Child & Adolescent Psychiatry 2021, 32: 903-914. PMID: 34853911, DOI: 10.1007/s00787-021-01923-2.Peer-Reviewed Original ResearchConceptsMental health disordersStressful life eventsEarly adulthoodHealth disordersPreventable risk factorsDifferent stressful life eventsInternalizing disordersBrazilian cohort studyProspective community cohortWell-Being AssessmentCohort studyCommunity cohortRisk factorsStratified analysisPsychiatric diagnosisExternalizing disordersChildhood povertyDisordersBaselineAdulthoodStandardized classificationHigh exposureLife eventsAssociationYoung peopleMental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action
Terra T, Schafer J, Pan P, Costa A, Caye A, Gadelha A, Miguel E, Bressan R, Rohde L, Salum G. Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action. Journal Of Affective Disorders 2021, 298: 190-193. PMID: 34715179, DOI: 10.1016/j.jad.2021.10.108.Peer-Reviewed Original ResearchConceptsAsexual youthMental disordersWell-Being Behavior AssessmentHigh-risk cohortMental health conditionsPost-traumatic stress disorderAttention deficit hyperactivity disorderMental health problemsDeficit hyperactivity disorderMental health disparitiesStressful life eventsDepressive disorderPsychiatric disordersPrevalence estimatesHealth problemsConfidential questionnaireHealth disparitiesLogistic regressionStress disorderAnxiety disordersHealth conditionsConduct disorderGroup comparisonsHyperactivity disorderDisordersHow do daily routines and situational factors affect the severity of obsessive-compulsive disorder?
Brierley M, Albertella L, do Rosário M, Ferrão Y, Miguel E, Fontenelle L. How do daily routines and situational factors affect the severity of obsessive-compulsive disorder? Journal Of Psychiatric Research 2021, 143: 395-399. PMID: 34600268, DOI: 10.1016/j.jpsychires.2021.09.040.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderOCD symptom severitySymptom severityOCD symptomsOCD patientsSevere OCD symptomsYale-Brown ObsessiveCross-sectional designReport symptomsHistory questionnaireCommon biological abnormalitiesBiological abnormalitiesClinical implicationsSymptomsDaily routineCompulsive ScaleSeverityMultivariate regressionPatientsRoutine factorsDisordersPredictors of gaming disorder in children and adolescents: a school-based study
Ferreira F, Bambini B, Tonsig G, Fonseca L, Picon F, Pan P, Salum G, Jackowski A, Miguel E, Rohde L, Bressan R, Gadelha A. Predictors of gaming disorder in children and adolescents: a school-based study. Brazilian Journal Of Psychiatry 2021, 43: 289-292. PMID: 32756806, PMCID: PMC8136393, DOI: 10.1590/1516-4446-2020-0964.Peer-Reviewed Original ResearchConceptsMental disordersWell-Being Behavior AssessmentHigh-risk cohortLogistic regression modelsSchool-based studyGaming disorderPsychiatric disordersUnhealthy patternsDisorder ratesSchool-based sampleDisordersSignificant predictorsFurther riskBrazilian High-Risk CohortCommunity sampleHigh rateBehavior changeMore hoursRegression modelsChildrenPredictorsAdolescentsHoursBehavior assessmentPattern variablesToward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder
Shephard E, Stern E, van den Heuvel O, Costa D, Batistuzzo M, Godoy P, Lopes A, Brunoni A, Hoexter M, Shavitt R, Reddy Y, Lochner C, Stein D, Simpson H, Miguel E. Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder. Molecular Psychiatry 2021, 26: 4583-4604. PMID: 33414496, PMCID: PMC8260628, DOI: 10.1038/s41380-020-01007-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCognitive neuroscienceNeurobiological alterationsMental health researchClinical profileFuture researchCase vignettesPsychiatric symptomsNeuromodulatory treatmentDifferent clinical profilesNeuroscienceEffective treatmentDisordersResearchBehavioralVignettesFindingsHealth researchTreatmentDysfunctionSymptomsPhenotypic expressionImportant limitationsTaxonomyPatientsPsychotic-like Experiences and Common Mental Disorders in Childhood and Adolescence: Bidirectional and Transdiagnostic Associations in a Longitudinal Community-based Study
Giocondo J, Salum G, Gadelha A, Argolo F, Simioni A, Mari J, Miguel E, Bressan R, Rohde L, Pan P. Psychotic-like Experiences and Common Mental Disorders in Childhood and Adolescence: Bidirectional and Transdiagnostic Associations in a Longitudinal Community-based Study. Schizophrenia Bulletin Open 2021, 2: sgab028. DOI: 10.1093/schizbullopen/sgab028.Peer-Reviewed Original ResearchCommon mental disordersComorbid psychiatric disordersRisk of PLEsCommunity-based studyMental disordersPsychiatric disordersPsychotic-like experiencesDepressive disorderLongitudinal community-based studyBidirectional associationsCommon psychiatric disordersSubthreshold psychotic symptomsNon-psychotic disordersSubsequent depressive disordersYear old subjectsPsychotic symptomsOlder subjectsCutoff valueComorbidity analysisClinician ratingsSubstance useDisordersBaseline ADHDDistinct phenotypesRisk
2020
Stressful Life Events and the Clinical Expression of Obsessive–Compulsive Disorder (OCD): An Exploratory Study
Imthon A, Caldart C, do Rosário M, Fontenelle L, Miguel E, Ferrão Y. Stressful Life Events and the Clinical Expression of Obsessive–Compulsive Disorder (OCD): An Exploratory Study. Journal Of Clinical Medicine 2020, 9: 3371. PMID: 33096706, PMCID: PMC7590000, DOI: 10.3390/jcm9103371.Peer-Reviewed Original ResearchStressful life eventsObsessive-compulsive disorderPost-traumatic stress disorderOCD patientsOccurrence of SLEsNonwhite skin colorLife eventsLogistic regression variablesCross-sectional studySensory phenomenaYale-Brown ObsessiveClinical characteristicsClinical expressionPsychiatric disordersHistory questionnairePatientsObsessive-compulsive symptomsStress disorderCompulsive ScaleDimensional Yale-Brown ObsessiveStatistical significanceDisordersPositive associationOCD symptomsSymptoms