2005
Association of Linear Plasmid 28-1 with an Arthritic Phenotype of Borrelia burgdorferi
Xu Q, Seemanapalli SV, Lomax L, McShan K, Li X, Fikrig E, Liang FT. Association of Linear Plasmid 28-1 with an Arthritic Phenotype of Borrelia burgdorferi. Infection And Immunity 2005, 73: 7208-7215. PMID: 16239515, PMCID: PMC1273894, DOI: 10.1128/iai.73.11.7208-7215.2005.Peer-Reviewed Original ResearchConceptsSevere combined immunodeficiencyArthritic phenotypeLp28-1Linear plasmid 28Borrelia burgdorferiArthritic pathologySevere arthritisSpirochete burdenSCID miceJoint tissuesLoss of plasmidsCombined immunodeficiencyPlasmid content analysisLyme disease spirocheteInfectivity studiesPlasmid patternsDecreased infectivityVirulence factorsFurther studiesMiceBurgdorferiBacterial quantificationPathogenicity studiesTissuePhenotype
1997
Protective and Arthritis-Resolving Activity in Sera of Mice Infected with Borrelia burgdorferi
Barthold S, Feng S, Bockenstedt L, Fikrig E, Feen K. Protective and Arthritis-Resolving Activity in Sera of Mice Infected with Borrelia burgdorferi. Clinical Infectious Diseases 1997, 25: s9-s17. PMID: 9233658, DOI: 10.1086/516166.Peer-Reviewed Original ResearchConceptsImmune serumSyringe challengePassive protective activitySerum of miceArthritis resolutionHost-adapted spirochetesImmunocompetent miceJoint tissuesTissue transplantsProtective activityImmunodominant regionMiceSerumInfectionBorrelia burgdorferiB. burgdorferiRecombinant formBurgdorferiSpirochetesTissueChallenge inoculationCarditisTransplantSpirochetemiaAntigen
1993
Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neuroblastoma cell line.
Fikrig E, Berland R, Chen M, Williams S, Sigal LH, Flavell RA. Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neuroblastoma cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 183-187. PMID: 7678336, PMCID: PMC45624, DOI: 10.1073/pnas.90.1.183.Peer-Reviewed Original ResearchConceptsNeuroblastoma cell linesHuman neuroblastoma cell linePatient seraCell linesPathogenesis of neuroborreliosisNeural tissueB. burgdorferi flagellinB-cell epitopesAmino acids 213Neurologic manifestationsSerologic responseSpecific B-cell epitopesBorrelia burgdorferi flagellinImmune responseLyme borreliosisMonoclonal antibodiesRecombinant fusion proteinSerumAntibodiesBorrelia burgdorferiEpitopesEpitope mappingFlagellinTissueNeuroborreliosis