2002
The Lyme Disease Vaccine Takes Its Toll
Thomas V, Fikrig E. The Lyme Disease Vaccine Takes Its Toll. Vector-Borne And Zoonotic Diseases 2002, 2: 217-222. PMID: 12804162, DOI: 10.1089/153036602321653798.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiHumansLipoproteinsLyme DiseaseLyme Disease VaccinesMembrane GlycoproteinsMiceMice, KnockoutReceptors, Cell SurfaceToll-Like Receptor 1Toll-Like Receptor 2Toll-Like ReceptorsConceptsTLR2-deficient miceToll-like receptorsPathogen-associated molecular patternsOspA antibodiesSpecific Toll-like receptorsBorrelia burgdorferi outer surface proteinDetectable humoral responseMolecular patternsProtective immune responseLyme disease vaccineDistinct pathogen-associated molecular patternsVaccine recipientsHumoral responseOspA vaccineCell surface expressionOspA vaccinationImmune responseDisease vaccineInnate responseTLR2Protective responseOuter surface proteinsTLR1Lyme diseaseDevelopment of responses
1996
P55, an immunogenic but nonprotective 55-kilodalton Borrelia burgdorferi protein in murine Lyme disease
Feng S, Barthold SW, Telford SR, Fikrig E. P55, an immunogenic but nonprotective 55-kilodalton Borrelia burgdorferi protein in murine Lyme disease. Infection And Immunity 1996, 64: 363-365. PMID: 8557366, PMCID: PMC173770, DOI: 10.1128/iai.64.1.363-365.1996.Peer-Reviewed Original ResearchConceptsProtective responseB. burgdorferi challengeMurine Lyme diseaseStrong antibody responseB. burgdorferi infectionBorrelia burgdorferi proteinsComplete Freund'sControl miceAntibody responseC3H miceBurgdorferi infectionImmunogenic antigensAnti-p55 antibodyLyme diseaseMiceP55B. burgdorferiInfectionAntigenResponseImmunizationFusion proteinTicksDiseaseFreund's