2011
O4-S2.05 Myd-88 deficient mice show evidence of productive T pallidum infection"
Dunne D, Silver A, Fieber J, Zeiss C, Fikrig E. O4-S2.05 Myd-88 deficient mice show evidence of productive T pallidum infection". Sexually Transmitted Infections 2011, 87: a87. DOI: 10.1136/sextrans-2011-050109.149.Peer-Reviewed Original ResearchMyD-88C57BL/6 miceDeficient miceImmunohistochemical stainsImmune responseMurine modelT pallidumDay 10Intact innate immune responseOnly natural reservoirNew Zealand male rabbitsB6 control miceInnate immune cellsUseful murine modelAged C57BL/6 miceWild-type miceInnate immune responseInnate immune systemPattern recognition receptorsImmune response mechanismsDownstream cytokine responsesSyphilis infectionSystemic illnessLymph nodesCytokine responsesInnate interleukin-22 confers protection during acute liver infection (114.8)
Zenewicz L, Pedra J, Booth C, Fikrig E, Flavell R. Innate interleukin-22 confers protection during acute liver infection (114.8). The Journal Of Immunology 2011, 186: 114.8-114.8. DOI: 10.4049/jimmunol.186.supp.114.8.Peer-Reviewed Original ResearchLTi-like cellsIL-22Liver infectionLiver immune responseObligate intracellular bacterium Anaplasma phagocytophilumInnate immune cellsLymphoid tissue inducerIL-22 receptorRole of innateIL-22-dependent mannerTissue responseImportant protective roleBacterium Anaplasma phagocytophilumA. phagocytophilum infectionIL-23Liver injuryImmune cellsLymphoid tissueInterleukin-22Immune responseGastrointestinal tractImportant cytokineConfer protectionProtective roleBacterial infections
2009
Innate Immune Responses to West Nile Virus Infection
Arjona A, Fikrig E. Innate Immune Responses to West Nile Virus Infection. Emerging Infectious Diseases Of The 21st Century 2009, 169-187. DOI: 10.1007/978-0-387-79840-0_8.Peer-Reviewed Original ResearchWest Nile virus infectionPathogen recognition receptorsImmune cellsVirus infectionImmune responseBlood-brain barrier permeabilityInnate immune cellsAdaptive immune responsesInnate immune mechanismsInnate immune responseInnate antiviral immunityWNV neuroinvasionProinflammatory cytokinesCostimulatory moleculesImmune mechanismsBarrier permeabilityAntiviral immunityWNV infectionInnate responseAntiviral stateInfectionCytokinesDetrimental effectsCurrent understandingImmunopathogenesis