1997
Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice
Bockenstedt LK, Hodzic E, Feng S, Bourrel KW, de Silva A, Montgomery RR, Fikrig E, Radolf JD, Barthold SW. Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice. Infection And Immunity 1997, 65: 4661-4667. PMID: 9353047, PMCID: PMC175668, DOI: 10.1128/iai.65.11.4661-4667.1997.Peer-Reviewed Original ResearchConceptsChallenge infectionC antiserumImmunization studiesStrain-specific immunityAntibody-mediated immunityPassive immunization studiesImmune mouse serumSurface protein AOuter surface protein ADisease regressionInfected miceBorreliacidal activityC antibodySpirochete Borrelia burgdorferiAnimal modelsImmune serumMouse serumInfectionLyme borreliosisMiceHyperimmune serumOsp AImmunofluorescence studiesBorrelia burgdorferiSurface expression
1995
Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi
Barthold SW, Fikrig E, Bockenstedt LK, Persing DH. Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infection And Immunity 1995, 63: 2255-2261. PMID: 7768606, PMCID: PMC173294, DOI: 10.1128/iai.63.6.2255-2261.1995.Peer-Reviewed Original ResearchConceptsInfectious doseInfected skinCultured Borrelia burgdorferiBorrelia burgdorferiLow-dose infectionMedian infectious doseNumber of spirochetesSurface protein ASyringe challengeB. burgdorferi OspAOuter surface protein AChallenge doseDisseminated infectionHost-adapted spirochetesSkin transplantsSyngenic miceOuter surface proteinsMiceHyperimmune serumDoseImmunologic recognitionInfectionSeroconversionTransplantationDisease development