Erick Awuoche
Postdoctoral AssociateAbout
Research
Publications
2025
Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes
Awuoche E, Smallenberger G, Bruzzese D, Orfano A, Weiss B, Aksoy S. Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes. PLOS Pathogens 2025, 21: e1012692. PMID: 39888974, PMCID: PMC11819587, DOI: 10.1371/journal.ppat.1012692.Peer-Reviewed Original ResearchConceptsHost physiologyInsect stage procyclic formsPrevent gut colonizationHigh-throughput RNA sequencingHost-pathogen dynamicsImmunity-related genesInfluence of microbiotaReduced lipid availabilitySubgroup speciesPresence of SpiroplasmaLipid biosynthesisExpression regulationGut colonizationGut environmentMicrobiota compositionProcyclic formsSpiroplasma infectionEscherichia coliRNA sequencingLipid synthesisTrypanosoma brucei parasitesInfection processSpiroplasmaGenetic traitsAfrican trypanosomes
2024
Publisher Correction: Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei
Beaver A, Keneskhanova Z, Cosentino R, Weiss B, Awuoche E, Smallenberger G, Buenconsejo G, Crilly N, Smith J, Hakim J, Zhang B, Bobb B, Rijo-Ferreira F, Figueiredo L, Aksoy S, Siegel T, Mugnier M. Publisher Correction: Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei. Nature 2024, 636: e3-e3. PMID: 39550527, PMCID: PMC11634761, DOI: 10.1038/s41586-024-08389-7.Peer-Reviewed Original ResearchTissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei
Beaver A, Keneskhanova Z, Cosentino R, Weiss B, Awuoche E, Smallenberger G, Buenconsejo G, Crilly N, Smith J, Hakim J, Zhang B, Bobb B, Rijo-Ferreira F, Figueiredo L, Aksoy S, Siegel T, Mugnier M. Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei. Nature 2024, 636: 430-437. PMID: 39478231, PMCID: PMC11634766, DOI: 10.1038/s41586-024-08151-z.Peer-Reviewed Original ResearchVariant surface glycoproteinAntigenic diversityAntigenic variationHigh-throughput sequencing approachDense variant surface glycoproteinPopulations of T. bruceiDynamics of antigenic variationGenomic repertoirePathogen diversificationSequencing approachExtravascular spaceTrypanosoma bruceiVariation in vivoHost immune systemAntigenic variation in vivoSurface glycoproteinSlow immune responseDiversitySwitching expressionParasite populations