2013
The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor
Podurgiel S, Nunes E, Yohn S, Barber J, Thompson A, Milligan M, Lee C, López-Cruz L, Pardo M, Valverde O, Lendent C, Baqi Y, Müller C, Correa M, Salamone J. The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor. Neuroscience 2013, 250: 507-519. PMID: 23867769, DOI: 10.1016/j.neuroscience.2013.07.008.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAnimalsCatalepsyData Interpretation, StatisticalDisease Models, AnimalDose-Response Relationship, DrugJawMaleMiceMice, KnockoutMotor ActivityMovementParkinsonian DisordersProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleyReceptor, Adenosine A2ATetrabenazineTremorVesicular Monoamine Transport ProteinsXanthinesConceptsTremulous jaw movementsVentrolateral neostriatumC-fos expressionMSX-3Receptor transmissionAdenosine A2A antagonist MSX-3A2A receptor knockout miceParkinsonian tremorC-Fos-positive cellsAbility of tetrabenazineParkinsonian side effectsVesicular monoamine storageJaw movementsReceptor knockout miceAdenosine A2A receptorsOral tremorWild-type controlsPharmacological antagonismStriatal dopamineLocomotor suppressionMotor effectsCD1 miceRodent modelsKnockout miceSide effects
2011
Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists
Randall P, Nunes E, Janniere S, Stopper C, Farrar A, Sager T, Baqi Y, Hockemeyer J, Müller C, Salamone J. Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists. Psychopharmacology 2011, 216: 173-186. PMID: 21347642, PMCID: PMC3522121, DOI: 10.1007/s00213-011-2198-3.Peer-Reviewed Original Research
2010
Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism
Nunes E, Randall P, Santerre J, Given A, Sager T, Correa M, Salamone J. Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism. Neuroscience 2010, 170: 268-280. PMID: 20600675, PMCID: PMC3268040, DOI: 10.1016/j.neuroscience.2010.05.068.Peer-Reviewed Original ResearchConceptsEffects of dopamineEffects of ecopipamSame striatal neuronsEffects of adenosineAbility of adenosineEffort-related impairmentsEffort-related choiceFood-seeking behaviorEffort-related choice behaviorConcurrent leverChow intakeDA transmissionSelective adenosine antagonistsStriatal neuronsReceptor antagonistRodent chowDopamine D1D2 antagonismPsychiatric symptomsPsychomotor slowingAdenosine antagonistEffort-related processesBrain circuitryAntagonistMesolimbic dopamine
2009
Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats
Sink K, Segovia K, Nunes E, Collins L, Vemuri V, Thakur G, Makriyannis A, Salamone J. Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats. Psychopharmacology 2009, 206: 223-232. PMID: 19588124, PMCID: PMC4425366, DOI: 10.1007/s00213-009-1602-8.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBehavior, AnimalConditioning, OperantDose-Response Relationship, DrugDrug Administration RoutesDrug InteractionsEatingFood DeprivationInjections, IntraventricularMaleMotor ActivityPiperidinesPyrazolesRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Reinforcement ScheduleReinforcement, PsychologyConceptsFood-reinforced behaviorCB1 receptorsLocomotor suppressionFood-motivated behaviorCannabinoid CB1 receptorsCB1 neutral antagonistsSame dose rangeModulation of locomotionIntracerebroventricular administrationICV administrationLocus of actionLower brainstemReceptor transmissionPeripheral receptorsSystemic administrationLateral ventricleAppetite suppressantsNucleus accumbensAM251AM4113Inverse agonistNeutral antagonistsDose rangeAdministrationReceptorsThe adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure
Mott A, Nunes E, Collins L, Port R, Sink K, Hockemeyer J, Müller C, Salamone J. The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure. Psychopharmacology 2009, 204: 103. PMID: 19132351, PMCID: PMC2875244, DOI: 10.1007/s00213-008-1441-z.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine A1 Receptor AntagonistsAdenosine A2 Receptor AntagonistsAnimalsBehavior, AnimalChoice BehaviorConditioning, OperantDopamine AntagonistsDose-Response Relationship, DrugDrug InteractionsHaloperidolMaleMaze LearningMotivationNucleus AccumbensPhysical ExertionPsychomotor PerformanceRatsRats, Sprague-DawleyReceptor, Adenosine A1Receptors, Adenosine A2Reinforcement ScheduleXanthinesConceptsEffort-related choiceMSX-3Antagonist haloperidolAdenosine A2A antagonist MSX-3Receptor antagonist MSX-3Adenosine A2A antagonismDA antagonist haloperidolDopamine antagonist haloperidolEffects of haloperidolEffort-related decision makingFood-seeking behaviorA2A antagonismDA transmissionUntreated ratsA1 antagonistD2 receptorsPsychiatric symptomsAdenosine A2APsychomotor slowingA1 antagonismEffort-related processesBrain circuitryFood-reinforced tasksHaloperidolBehavioral activation