2020
mTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses
Karam BS, Morris RS, Bramante CT, Puskarich M, Zolfaghari EJ, Lotfi‐Emran S, Ingraham NE, Charles A, Odde DJ, Tignanelli CJ. mTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses. Journal Of Medical Virology 2020, 93: 1843-1846. PMID: 33314219, PMCID: PMC8159020, DOI: 10.1002/jmv.26728.Peer-Reviewed Original ResearchConceptsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionCoronavirus 2 infectionReview of efficacyCoronavirus disease 2019Modulation of mTORSARS-CoV-2RNA virusesDisease 2019Recent evidence pointsMTOR inhibitorsViral infectionMTOR inhibitionMTOR pathwayMammalian targetRapamycin (mTOR) pathwayNumerous RNA virusesVirus growthCOVID-19MTOR resultsInfectionCurrent literatureHighlight evidenceEvidence points
2017
Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft
Kim JW, Jacobsen B, Zolfaghari E, Ferrario A, Chevez-Barrios P, Berry JL, Lee DK, Rico G, Madi I, Rao N, Stachelek K, Wang LC, Gomer C. Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft. Graefe's Archive For Clinical And Experimental Ophthalmology 2017, 255: 2363-2373. PMID: 28971251, DOI: 10.1007/s00417-017-3805-8.Peer-Reviewed Original ResearchConceptsRetinoblastoma xenograftsRabbit retinaPhotodynamic therapyLaser delivery systemTreatment of retinoblastomaPre-clinical studiesPhase 1Intraocular retinoblastomaIntravenous verteporfinRetinal scarsSubretinal tumorsDelivery systemRetinal damageRight eyeHistopathologic examinationOcular toxicityTumor necrosisOcular damageControl rabbitsTreatment durationRabbit modelVerteporfinWavelength diode laserThermal burnsPDT treatment