2022
Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives
Pigg H, Yglesias M, Sutton E, McDevitt C, Shaw M, DeRose V. Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives. ACS Chemical Biology 2022, 17: 2262-2271. PMID: 35917257, DOI: 10.1021/acschembio.2c00399.Peer-Reviewed Original ResearchConceptsNucleolar stressStress inductionHigh overall degreeSpecific cellular responsesRibosome biogenesisRRNA transcriptionConformation showCellular responsesCell deathDNA damageKey intermolecular interactionsH drug treatmentMechanistic understandingCellular accumulationSmall moleculesDNA adduct formationInductionBiogenesisTranscriptionStressInhibitionAdduct formationInteractionPotential explanationConformation
2019
Monofunctional platinum(II) compounds and nucleolar stress: is phenanthriplatin unique?
McDevitt CE, Yglesias MV, Mroz AM, Sutton EC, Yang MC, Hendon CH, DeRose VJ. Monofunctional platinum(II) compounds and nucleolar stress: is phenanthriplatin unique? JBIC Journal Of Biological Inorganic Chemistry 2019, 24: 899-908. PMID: 31494760, PMCID: PMC7660985, DOI: 10.1007/s00775-019-01707-9.Peer-Reviewed Original Research