Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives
Pigg H, Yglesias M, Sutton E, McDevitt C, Shaw M, DeRose V. Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives. ACS Chemical Biology 2022, 17: 2262-2271. PMID: 35917257, DOI: 10.1021/acschembio.2c00399.Peer-Reviewed Original ResearchConceptsNucleolar stressStress inductionHigh overall degreeSpecific cellular responsesRibosome biogenesisRRNA transcriptionConformation showCellular responsesCell deathDNA damageKey intermolecular interactionsH drug treatmentMechanistic understandingCellular accumulationSmall moleculesDNA adduct formationInductionBiogenesisTranscriptionStressInhibitionAdduct formationInteractionPotential explanationConformation