2024
Clinical use of Gafchromic EBT4 film for in vivo dosimetry for total body irradiation
Draeger E, Guan F, Lee M, Han D, Donahue W, Chen Z. Clinical use of Gafchromic EBT4 film for in vivo dosimetry for total body irradiation. Journal Of Applied Clinical Medical Physics 2024, e14574. PMID: 39611814, DOI: 10.1002/acm2.14574.Peer-Reviewed Original ResearchOptically stimulated luminescence dosimetersIn vivo dosimetryTotal body irradiation patientsIon chamberThermoluminescent dosimetersDiode readingsDose measurementsFilm measurementsTotal body irradiationOSLD measurementsAccurate in vivo dosimetryExit dose measurementsSolid water phantomAccurate dose measurementsFilm calibration curvesWater phantomExit doseLuminescence dosimetersAccurate dosimetryMeasured entranceBody irradiationDosimetryTotal body irradiation conditioningDosimetersDiodes3D gamma analysis between treatment plans for nominally beam‐matched medical linear accelerators using PyMedPhys
Guan F, Donahue W, Biggs S, Jennings M, Draeger E, Chen H, Wang Y, Nguyen N, Carlson D, Chen Z, Han D. 3D gamma analysis between treatment plans for nominally beam‐matched medical linear accelerators using PyMedPhys. Precision Radiation Oncology 2024 DOI: 10.1002/pro6.1247.Peer-Reviewed Original ResearchGamma analysisGamma indexEvaluation of treatment plansPlanned dose distributionMedical linear acceleratorPass rateEfficient treatment deliveryMedian pass rateDose distributionTreatment planningLinacLinear acceleratorCalculated doseTreatment deliveryConformal radiotherapyOriginal planRadiation therapyPatient transferDisease sitesIn-house scriptsBeam modelPatientsBeamRadiotherapyAccelerationThursday, July 11, 20244:00 PM - 5:00 PM PP01 Presentation Time: 4:00 PM Investigating Shielding as a Dose-Shaping Tool in Flattening Distal Dose Profiles for Single-Channel Vaginal Cylinders
Tien C, Mullane S, Draeger E, Rivard M, Chen Z. Thursday, July 11, 20244:00 PM - 5:00 PM PP01 Presentation Time: 4:00 PM Investigating Shielding as a Dose-Shaping Tool in Flattening Distal Dose Profiles for Single-Channel Vaginal Cylinders. Brachytherapy 2024, 23: s26-s27. DOI: 10.1016/j.brachy.2024.08.020.Peer-Reviewed Original ResearchModel-based dose calculation algorithmsSingle-channel vaginal cylinderDose profilesDose distributionVaginal cylinderCentral axisCustomized shieldingRegions of high doseAnisotropic dose distributionUniform dose profileDose calculation algorithmWater-equivalent materialDose calculation methodMonte CarloIr-192 seedsDose gridIr-192MC simulationsRelative doseShielding materialsCalculation algorithmSource transitionDose optimizationLateral radiusShieldingPO0116 Design and Characterization of a Brachytherapy Applicator with Modulated Shielding (MOSH) for the Treatment of Cervical Cancer
Schwipper C, Mullane S, Draeger E, Chen Z, Rivard M, Tien C. PO0116 Design and Characterization of a Brachytherapy Applicator with Modulated Shielding (MOSH) for the Treatment of Cervical Cancer. Brachytherapy 2024, 23: s92. DOI: 10.1016/j.brachy.2024.08.134.Peer-Reviewed Original ResearchDose distributionBrachytherapy applicationsOAR dosesIr-192TG-43 dose calculation formalismShield geometryReduces dose to OARAAPM TG-43 formalismShielding materialsDose calculation formalismHigh-Z shieldingReduced OAR dosesCalculated dose distributionsTG-43 formalismDose-volume objectivesDose to OARsTreatment of cervical cancerHDR brachytherapy applicatorsHigh-risk clinical target volumeIr-192 sourceImproved dose distributionClinical target volumeSparing OARsTOPAS MCYb-169Prompt-gamma imaging in particle therapy
Magalhaes Martins P, Draeger E, Wronska A. Prompt-gamma imaging in particle therapy. Frontiers in Physics 12, 1502908Commentaries, Editorials and LettersEditorial: Prompt-gamma imaging in particle therapy
Martins P, Draeger E, Wrońska A. Editorial: Prompt-gamma imaging in particle therapy. Frontiers In Physics 2024, 12: 1502908. DOI: 10.3389/fphy.2024.1502908.Peer-Reviewed Original Research
2023
In Vivo Verification of Electron Paramagnetic Resonance Biodosimetry Using Patients Undergoing Radiation Therapy Treatment
Draeger E, Roberts K, Decker R, Bahar N, Wilson L, Contessa J, Husain Z, Williams B, Flood A, Swartz H, Carlson D. In Vivo Verification of Electron Paramagnetic Resonance Biodosimetry Using Patients Undergoing Radiation Therapy Treatment. International Journal Of Radiation Oncology • Biology • Physics 2023, 119: 292-301. PMID: 38072322, DOI: 10.1016/j.ijrobp.2023.11.029.Peer-Reviewed Original ResearchHealthy volunteersDose rangeTotal body irradiationTotal body irradiation treatmentSignificant correlationRadiation therapy patientsPatient ageBody irradiationImmediate triageTherapy patientsClinical conditionsParticipants' teethPatientsNeck patientsUnknown dosesDosePatient dataRadiotherapy treatmentRadiation doseTeethTreatmentVolunteersSubsequent fractionsLuminescent dosimetersRadiation responsePO61 Can Current Monotherapy High-Dose-Rate Prostate Brachytherapy Prescriptions Overcome Intrafractional DNA Damage Repair and 192Ir Source Decay?
Guan F, Draeger E, Carlson D, Chen Z, Tien C. PO61 Can Current Monotherapy High-Dose-Rate Prostate Brachytherapy Prescriptions Overcome Intrafractional DNA Damage Repair and 192Ir Source Decay? Brachytherapy 2023, 22: s97-s98. DOI: 10.1016/j.brachy.2023.06.162.Peer-Reviewed Original ResearchPO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model
Tien C, Draeger E, Guan F, Carlson D, Chen Z. PO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model. Brachytherapy 2023, 22: s110. DOI: 10.1016/j.brachy.2023.06.184.Peer-Reviewed Original ResearchTumor control probabilityClinical trialsLinear-quadratic modelNumber of patientsPatient cohort sizeTCP curvesRadiobiological parametersVirtual clinical trialsGy-1Cohort sizeRange of dosesPatient outcomesReference cohortPatientsHeterogeneous cohortVirtual patientsNew trialsRadiobiological parameter valuesClonogenic populationPatient ordersControl probabilityGyInput model parametersTrialsCohortCharacterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons
Guan F, Chen H, Draeger E, Li Y, Aydin R, Tien C, Chen Z. Characterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons. Precision Radiation Oncology 2023, 7: 84-91. DOI: 10.1002/pro6.1204.Peer-Reviewed Original ResearchX-ray beamMeV electron beamMV photon beamElectron beamMV photonsBeam energyMeV electronsPhoton beamsEnergy dependenceKilovoltage x-ray beamsMinimal energy dependenceClinical photonPhotonsBeamRadiation typesMeVElectronsDependence experimentsFilmsDose-response dependenceResponse dependenceDependenceEnergyNoise ratioEBT3Characterization of Gafchromic EBT4 film with clinical kV/MV photons and MeV electrons
Guan F, Chen H, Draeger E, Li Y, Aydin R, Tien CJ, Chen Z. Characterization of Gafchromic EBT4 film with clinical kV/MV photons and MeV electrons. Precision Radiation Oncology 2023, 7(2):84-91. DOI: 10.1002/pro6.1204.Peer-Reviewed Original ResearchPreliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems
Draeger E, Chen Z, Hansen JE, Chiang V, Tien CJ (2023) Preliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems. Journal of Applied Clinical Medical Physics, 25(5):e13907. DOI: 10.1002/acm2.13907.Peer-Reviewed Original ResearchFrequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi-vendor environment
Donahue WP, Draeger E, Han D, Chen Z. Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi-vendor environment. Journal of Applied Clinical Medical Physics 2023, 24(4):e13868. DOI: 10.1002/acm2.13868.Peer-Reviewed Original ResearchDosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons
Guan F, Wang X, Yang M, Draeger E, Han D, Iga K, Guo F, Perles L, Li Y, Sahoo N, Mohan R, Chen Z. Dosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons. Precision Radiation Oncology 2023, 7: 15-26. PMID: 37868341, PMCID: PMC10586355, DOI: 10.1002/pro6.1187.Peer-Reviewed Original ResearchLinear energy transferEBT-XD filmsTherapeutic protonsFilm calibrationProton linear energy transferUltra-high Dose Rate FLASH RadiotherapyDynamic dose rangeMV photon beamDose-averaged LET valuesDose rate dependenceProton beamlineProton beamPhoton beamsFLASH beamSpot scanning proton beamsDosimetric responseLET dependenceFLASH radiotherapyHigh-dose applicationFilm responseLET valuesEnergy transferBeamProtonsGafchromicDosimetric response of Gafchromic EBT-XD film to therapeutic protons
Guan F, Wang X, Yang M, Draeger E, Han D, Iga K, Guo F, Perles L, Li Y, Sahoo N, Mohan R, Chen Z. Dosimetric response of Gafchromic EBT-XD film to therapeutic protons. Precision Radiation Oncology 2023, 7(1):15-26. DOI: 10.1002/pro6.1187.Peer-Reviewed Original ResearchRe: Letter to the editor with regards to “Impact of detector selection on commissioning of Leipzig surface applicators with improving immobilization in high-dose-rate brachytherapy” by Li et al.
Tien C, Draeger E, Pinkham D, Carlson D, Jay Chen Z. Re: Letter to the editor with regards to “Impact of detector selection on commissioning of Leipzig surface applicators with improving immobilization in high-dose-rate brachytherapy” by Li et al. Brachytherapy 2023, 22: 290. PMID: 36707330, DOI: 10.1016/j.brachy.2022.11.004.Commentaries, Editorials and LettersPreliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems
Draeger E, Chen Z, Hansen J, Chiang V, Tien C. Preliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems. Journal Of Applied Clinical Medical Physics 2023, 24: e13907. PMID: 36660774, PMCID: PMC10161057, DOI: 10.1002/acm2.13907.Peer-Reviewed Original ResearchConceptsConformity indexRadiation Therapy Oncology Group conformity indexGK plansSuperior conformity indexNon-metastatic casesPaddick conformity indexDosimetric plan qualityGK patientsBrain metastasesRadiosurgery systemTrigeminal neuralgiaPrescription dosesGamma Knife systemMetastatic casesArteriovenous malformationsPituitary adenomasConformality indexLarge cohortDosimetric comparisonStereotactic radiosurgery systemGK IconPatientsCohortTreatment timeDosimetric results
2022
Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi‐vendor environment
Donahue W, Draeger E, Han D, Chen Z. Frequency of errors in the transfer of treatment parameters from the treatment planning system to the oncology information system in a multi‐vendor environment. Journal Of Applied Clinical Medical Physics 2022, 24: e13868. PMID: 36527239, PMCID: PMC10113690, DOI: 10.1002/acm2.13868.Peer-Reviewed Original ResearchConceptsInformation systemsTransfer of dataPlanning systemSoftware systemsOncology information systemMultiple vendorsData transferField labelsData inputTimer settingsNumber of errorsTechnological advancementsErrorSystemVendorsAdvancementTreatment planning systemFrequency of errorsMOSAIQCommon errorsLabelsInformationA small footprint couch‐top support device for image‐guided radiotherapy of heavy patients
Chen H, Morley K, Rodriguez R, Draeger E, Hassan M, Chen Z. A small footprint couch‐top support device for image‐guided radiotherapy of heavy patients. Journal Of Applied Clinical Medical Physics 2022, 23: e13788. PMID: 36267043, PMCID: PMC9797158, DOI: 10.1002/acm2.13788.Peer-Reviewed Original Research
2020
Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy
Draeger E, Pinkham DW, Chen ZJ, Tien CJ. Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy. Brachytherapy 2020, 20: 401-409. PMID: 33288488, DOI: 10.1016/j.brachy.2020.09.019.Peer-Reviewed Original Research