2020
The Impact of Radiation Energy on Dose Homogeneity and Organ Dose in the Gttingen Minipig Total-Body Irradiation Model
Poirier Y, Becker S, Decesaris C, Culberson W, Draeger E, Gerry AJ, Johnstone CD, Gibbs A, Vujaskovic Z, Jackson IL. The Impact of Radiation Energy on Dose Homogeneity and Organ Dose in the Gttingen Minipig Total-Body Irradiation Model. Radiation Research 2020, 194: 544-556. PMID: 33045066, DOI: 10.1667/rade-20-00135.1.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAbsorption, RadiationAnimalsBody SizeBody WeightCobalt RadioisotopesDose-Response Relationship, RadiationGamma RaysMaleModels, AnimalOrgan SpecificityParticle AcceleratorsPelvisPhotonsProne PositionRadiation DosageRadiation ToleranceRadioisotope TeletherapyRadiotherapy Planning, Computer-AssistedRadiotherapy, High-EnergyShoulderSwineSwine, MiniatureTomography, X-Ray ComputedWhole-Body IrradiationConceptsTotal body irradiationDose-volume histogramsGöttingen minipigsThoracic organsMedical countermeasuresRadiation dose-response relationshipDose-response relationshipNormal tissue damageDose distributionExperienced radiation oncologistsAdditional confounding factorsTBI modelPelvic organsHigh doseIndividual organsAnimal modelsAverage doseConfounding factorsRadiation oncologistsTissue damageLess doseOrgan doseAverage dosesDose homogeneityDose
2019
Hematological Effects of Non-Homogenous Ionizing Radiation Exposure in a Non-Human Primate Model
Jackson IL, Gibbs A, Poirier Y, Wathen L, Eley J, Draeger E, Gopalakrishnan M, Benjamin B, Vujaskovic Z. Hematological Effects of Non-Homogenous Ionizing Radiation Exposure in a Non-Human Primate Model. Radiation Research 2019, 191: 428-438. PMID: 30870098, DOI: 10.1667/rr15280.1.Peer-Reviewed Original ResearchConceptsLower half-body irradiationUpper half body irradiationHalf-body irradiationTotal body irradiationDose-volume effectsNon-human primatesBM toxicityRadiation exposureBone marrowClinical signs/symptomsRadiation dose-volume effectsNon-human primate modelHigh-grade feverSigns/symptomsBone marrow toxicityPeripheral blood samplesAcute radiation syndromeIonizing Radiation ExposureBlood-forming organsSevere neutropeniaRespiratory distressHematologic changesMarrow toxicityBM damagePrimate model