2016
Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia
Spracklen CN, Smith CJ, Saftlas AF, Triche EW, Bjonnes A, Keating BJ, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia. Hypertension In Pregnancy 2016, 36: 30-35. PMID: 27657194, PMCID: PMC5538572, DOI: 10.1080/10641955.2016.1223303.Peer-Reviewed Original ResearchConceptsC-reactive proteinGenetic risk scoreRisk of preeclampsiaBody mass indexGenetic predispositionCRP levelsPreeclampsia casesRisk scoreCRP genetic risk scoreElevated C-reactive proteinLeisure-time physical activityBlood CRP levelsIndependent replication populationMarkers of preeclampsiaElevated levelsMedical chart reviewLive birth certificatesLogistic regression analysisInverse linear trendChart reviewIowa womenNormotensive controlsDecreased riskMass indexPhysical activity
2014
Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia
Spracklen CN, Saftlas AF, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia. American Journal Of Hypertension 2014, 28: 915-923. PMID: 25523295, PMCID: PMC4542907, DOI: 10.1093/ajh/hpu242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlood PressureCase-Control StudiesChi-Square DistributionCholesterol, HDLCholesterol, LDLDyslipidemiasFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIowaLogistic ModelsMultivariate AnalysisOdds RatioPhenotypePolymorphism, Single NucleotidePre-EclampsiaPregnancyRisk FactorsTriglyceridesYoung Adult
2008
Prenatal Caffeine Assessment: Fetal and Maternal Biomarkers or Self-Reported Intake?
Grosso LM, Triche E, Benowitz NL, Bracken MB. Prenatal Caffeine Assessment: Fetal and Maternal Biomarkers or Self-Reported Intake? Annals Of Epidemiology 2008, 18: 172-178. PMID: 18083538, PMCID: PMC2275917, DOI: 10.1016/j.annepidem.2007.11.005.Peer-Reviewed Original ResearchConceptsMaternal urineCaffeine exposureUmbilical cord blood samplesCord blood biomarkersCord blood concentrationsInfants of smokersMaternal self reportsMaternal caffeine intakeCord blood samplesSelf-reported intakeUmbilical cord bloodMaternal biomarkersPregnant womenBlood biomarkersCord bloodObstetric practiceBlood concentrationsCaffeine intakeParaxanthine levelsBlood samplesPregnancySmokersCaffeine metabolismIntakeBiomarkers
2006
Caffeine Metabolites in Umbilical Cord Blood, Cytochrome P-450 1A2 Activity, and Intrauterine Growth Restriction
Grosso LM, Triche EW, Belanger K, Benowitz NL, Holford TR, Bracken MB. Caffeine Metabolites in Umbilical Cord Blood, Cytochrome P-450 1A2 Activity, and Intrauterine Growth Restriction. American Journal Of Epidemiology 2006, 163: 1035-1041. PMID: 16641310, DOI: 10.1093/aje/kwj125.Peer-Reviewed Original ResearchConceptsIntrauterine growth restrictionRisk of IUGRUmbilical cord bloodGrowth restrictionCord bloodCaffeine consumptionRatio of paraxanthineCytochrome PSelf-reported caffeine consumptionPreterm deliveryFetal exposureHighest quartileAdjusted analysisPregnant womenFetal growthObstetric practiceCYP1A2 activityParaxanthine levelsReproductive outcomesAdjusted modelAssociation of caffeineCaffeine metabolitesStandard deviation changeConflicting resultsQuartile