2020
Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain
Odriozola P, Gee DG. Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain. American Journal Of Psychiatry 2020, 178: 136-155. PMID: 33167673, PMCID: PMC7951569, DOI: 10.1176/appi.ajp.2020.20020232.Peer-Reviewed Original ResearchConceptsSafety signal learningExtinction learningSignal learningAnxiety disordersAnxious youthSafety cuesDorsal anterior cingulate cortexInhibition of fearFronto-amygdala circuitryCross-species evidenceAnterior cingulate cortexFear responsesAnxiety-like behaviorFrontolimbic circuitryCingulate cortexNeural circuitryCore featuresPrelimbic cortexBasic neuroscienceTranslational frameworkCuesYouthFearLearningAnimal modelsComparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study
Harrewijn A, Kitt ER, Abend R, Matsumoto C, Odriozola P, Winkler AM, Leibenluft E, Pine DS, Gee DG. Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study. Behavioural Brain Research 2020, 399: 112994. PMID: 33160010, PMCID: PMC7855938, DOI: 10.1016/j.bbr.2020.112994.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPediatric anxiety disordersAnxiety disordersNeural correlatesHigher skin conductance responsesDorsal anterior cingulate cortexRight ventromedial prefrontal cortexVentromedial prefrontal cortexSkin conductance responsesReduced fear responsesAnterior cingulate cortexCurrent pilot studyThreat learningAnxious youthSafety cuesThreat cuesFear acquisitionVmPFC activityAversive soundSafety compoundCBT responseFear responsesNovel cuesConductance responsesPrefrontal cortex
2018
Atypical frontoamygdala functional connectivity in youth with autism
Odriozola P, Dajani DR, Burrows CA, Gabard-Durnam LJ, Goodman E, Baez AC, Tottenham N, Uddin LQ, Gee DG. Atypical frontoamygdala functional connectivity in youth with autism. Developmental Cognitive Neuroscience 2018, 37: 100603. PMID: 30581125, PMCID: PMC6570504, DOI: 10.1016/j.dcn.2018.12.001.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderRostral anterior cingulate cortexFunctional connectivityTD individualsDifferent age-related patternsResting-state functional connectivityOverall group differencesBroad developmental rangeAnterior cingulate cortexSocioemotional functioningSocioemotional impairmentsSpectrum disorderCross-sectional sampleAge-related changesRight basolateral amygdalaCingulate cortexAge-related patternsGroup differencesDevelopmental rangeFrontoamygdala circuitryBasolateral amygdalaAmygdalaIndividualsPrior workImpairment
2015
Reliability of an fMRI paradigm for emotional processing in a multisite longitudinal study
Gee DG, McEwen SC, Forsyth JK, Haut KM, Bearden CE, Addington J, Goodyear B, Cadenhead KS, Mirzakhanian H, Cornblatt BA, Olvet D, Mathalon DH, McGlashan TH, Perkins DO, Belger A, Seidman LJ, Thermenos H, Tsuang MT, van Erp TG, Walker EF, Hamann S, Woods SW, Constable T, Cannon TD. Reliability of an fMRI paradigm for emotional processing in a multisite longitudinal study. Human Brain Mapping 2015, 36: 2558-2579. PMID: 25821147, PMCID: PMC4478164, DOI: 10.1002/hbm.22791.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imaging (fMRI) taskBlood oxygen level-dependent (BOLD) signalFusiform gyrusRobust activationEmotion processing areasAnterior cingulate cortexLevel-dependent signalBrain-related changesMean activationExcellent reliabilityPatient groupRare conditionInferior frontal gyrusHealthy volunteersGeneral populationEmotion processing taskHealthy individualsCingulate cortexMultisite longitudinal studyConsecutive daysFrontal gyrusAmygdalaBrain activationMultisite studyMixed effects models