1995
Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR
Mason G, Gruetter R, Rothman D, Behar K, Shulman R, Novotny E. Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR. Cerebrovascular And Brain Metabolism Reviews 1995, 15: 12-25. PMID: 7798329, DOI: 10.1038/jcbfm.1995.2.Peer-Reviewed Original Research
1993
Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation.
Chen W, Novotny E, Zhu X, Rothman D, Shulman R. Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 9896-9900. PMID: 8234332, PMCID: PMC47679, DOI: 10.1073/pnas.90.21.9896.Peer-Reviewed Original ResearchConceptsCerebral metabolic rateGlucose levelsPhotic stimulationBrain glucose concentrationsGlucose metabolic ratePrimary visual cortexAverage maximum changeMetabolic rateVisual cortex regionsBrain glucoseCalcarine fissureVisual cortexGlucose changesLactate concentrationCortex regionsVisual stimulationStimulationGlucose concentrationHuman brainGlucose consumptionGlucose transportIndividual subjectsMinCortexLevelsNMR-Spectroscopic Investigation of Cerebral Reanimation After Prolonged Ischemia
Hossmann K, Behar K, Rothman D. NMR-Spectroscopic Investigation of Cerebral Reanimation After Prolonged Ischemia. Acta Neurochirurgica Supplement 1993, 57: 21-29. PMID: 8421952, DOI: 10.1007/978-3-7091-9266-5_3.Peer-Reviewed Original ResearchConceptsHour complete ischemiaResidual blood flowBlood flowComplete ischemiaBrain injuryComplete recoveryBrain energy stateIrreversible brain injuryDuration of ischemiaAppropriate therapeutic measuresRise of lactatePost-ischemic injuryN-acetyl aspartateNon-invasive assessmentBrain glucose contentDepth of anesthesiaLower metabolite levelsBlood reperfusionIschemia timeReflow phenomenonBrain metabolismContinuous non-invasive assessmentProlonged ischemiaTherapeutic measuresIschemia