1998
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
Sibson N, Dhankhar A, Mason G, Rothman D, Behar K, Shulman R. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 316-321. PMID: 9419373, PMCID: PMC18211, DOI: 10.1073/pnas.95.1.316.Peer-Reviewed Original ResearchConceptsGlutamatergic neuronal activityGlutamate neurotransmitter cyclingNeuronal activityGln synthesisBrain glucose metabolismSynaptic glutamate releaseGlc metabolismGlutamate releaseRat cortexSynaptic activityGlucose metabolismNeuronal functionBrain activation studiesTricarboxylic acid cycleCortexMetabolismAcid cycleActivation studiesAstrocytesNeuronsActivity
1997
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling
Sibson N, Dhankhar A, Mason G, Behar K, Rothman D, Shulman R. In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2699-2704. PMID: 9122259, PMCID: PMC20152, DOI: 10.1073/pnas.94.6.2699.Peer-Reviewed Original Research
1996
Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis.
Shulman R, Rothman D. Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7491-7495. PMID: 8755501, PMCID: PMC38772, DOI: 10.1073/pnas.93.15.7491.Peer-Reviewed Original ResearchConceptsCovalent phosphorylationGlycogen synthaseGlycogen synthesisGlucose transportMuscle glycogen synthaseAllosteric activationMetabolic control analysisMetabolic homeostasisPhosphorylationGlycogenic fluxEnzymatic phosphorylationHexokinase stepGSaseMuscle cellsHomeostasisFractional activityMuscle glycogen synthesisSynthaseConcentrations of G6PG6P concentrationActivityEnzymeMechanismRoleHexokinase1H NMR Studies of Glucose Transport in the Human Brain
Gruetter R, Novotny† E, Boulware† S, Rothman* D, Shulman R. 1H NMR Studies of Glucose Transport in the Human Brain. Cerebrovascular And Brain Metabolism Reviews 1996, 16: 427-438. PMID: 8621747, DOI: 10.1097/00004647-199605000-00009.Peer-Reviewed Original Research
1995
Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR
Mason G, Gruetter R, Rothman D, Behar K, Shulman R, Novotny E. Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR. Cerebrovascular And Brain Metabolism Reviews 1995, 15: 12-25. PMID: 7798329, DOI: 10.1038/jcbfm.1995.2.Peer-Reviewed Original Research
1994
NMR studies of human brain function
Shulman R, Rothman D, Blamire A. NMR studies of human brain function. Trends In Biochemical Sciences 1994, 19: 522-526. PMID: 7846759, DOI: 10.1016/0968-0004(94)90050-7.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPositron emission tomographyUnstimulated subjectsResonance imagingEmission tomographyBrain functionHuman brain functionSensory stimulationVisual stimulationBrain activityHuman brain activityHuman brainStimulationMetabolic rateSignificant improvementMagnetic resonance spectroscopySingle subjectSubjectsEstablished method
1993
Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation.
Chen W, Novotny E, Zhu X, Rothman D, Shulman R. Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 9896-9900. PMID: 8234332, PMCID: PMC47679, DOI: 10.1073/pnas.90.21.9896.Peer-Reviewed Original ResearchConceptsCerebral metabolic rateGlucose levelsPhotic stimulationBrain glucose concentrationsGlucose metabolic ratePrimary visual cortexAverage maximum changeMetabolic rateVisual cortex regionsBrain glucoseCalcarine fissureVisual cortexGlucose changesLactate concentrationCortex regionsVisual stimulationStimulationGlucose concentrationHuman brainGlucose consumptionGlucose transportIndividual subjectsMinCortexLevels
1992
NMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat Brain
Mason G, Behar K, Rothman D, Shulman R. NMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 448-455. PMID: 1569138, DOI: 10.1038/jcbfm.1992.62.Peer-Reviewed Original Research
1991
13C-NMR measurements of muscle glycogen during low-intensity exercise
Price T, Rothman D, Avison M, Buonamico P, Shulman R. 13C-NMR measurements of muscle glycogen during low-intensity exercise. Journal Of Applied Physiology 1991, 70: 1836-1844. PMID: 2055862, DOI: 10.1152/jappl.1991.70.4.1836.Peer-Reviewed Original ResearchConceptsLow-intensity exerciseMuscle glycogenLight exerciseProtocol 1Blood velocityHours of exerciseMaximum voluntary contractionMin of onsetExercised legNonexercised legFemoral arteryVoluntary contractionGlycogen repletionHeavy exercisePlantar flexionGastrocnemius muscleFemale subjectsGlycogen levelsGlycogen metabolismFive minutesExerciseGlycogenSubjectsMagnetic resonance spectroscopyLeg
1990
1H NMR visibility of mammalian glycogen in solution.
Zang L, Rothman D, Shulman R. 1H NMR visibility of mammalian glycogen in solution. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 1678-1680. PMID: 2308928, PMCID: PMC53545, DOI: 10.1073/pnas.87.5.1678.Peer-Reviewed Original ResearchConceptsHigh molecular weightRapid intramolecular motionsNMR relaxation times T1Chemical shiftsNMR spectraIntramolecular motionsNMR visibilityMolecular weightMammalian glycogenCarbon nucleiRelaxation time T1Rabbit liver glycogenGlycogen contributeTime T1NMRGlycogenMoleculesProtonsExcellent agreementNucleus
1984
Carbon-13 nuclear magnetic resonance studies of myocardial glycogen metabolism in live guinea pigs.
Neurohr K, Gollin G, Neurohr J, Rothman D, Shulman R. Carbon-13 nuclear magnetic resonance studies of myocardial glycogen metabolism in live guinea pigs. Biochemistry 1984, 23: 5029-35. PMID: 6498174, DOI: 10.1021/bi00316a031.Peer-Reviewed Original ResearchDetection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).
Behar K, Rothman D, Shulman R, Petroff O, Prichard J. Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T). Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 2517-2519. PMID: 6585812, PMCID: PMC345093, DOI: 10.1073/pnas.81.8.2517.Peer-Reviewed Original Research