2023
Correcting for Bias Due to Mismeasured Exposure History in Longitudinal Studies with Continuous Outcomes
Cai J, Zhang N, Zhou X, Spiegelman D, Wang M. Correcting for Bias Due to Mismeasured Exposure History in Longitudinal Studies with Continuous Outcomes. Biometrics 2023, 79: 3739-3751. PMID: 37222518, PMCID: PMC11214728, DOI: 10.1111/biom.13877.Peer-Reviewed Original Research
2020
Estimation in the Cox survival regression model with covariate measurement error and a changepoint
Agami S, Zucker DM, Spiegelman D. Estimation in the Cox survival regression model with covariate measurement error and a changepoint. Biometrical Journal 2020, 62: 1139-1163. PMID: 32003495, DOI: 10.1002/bimj.201800085.Peer-Reviewed Original ResearchMeSH KeywordsBiasCalibrationCardiovascular DiseasesComputer SimulationHumansLongitudinal StudiesMyocardial InfarctionProportional Hazards ModelsSurvival AnalysisConceptsSystolic blood pressure levelsChronic air pollution exposureCox survival regression modelFatal myocardial infarctionBlood pressure levelsCardiovascular disease deathsCox regression modelAir pollution exposureRegression modelsDisease deathsMyocardial infarctionRelative riskStandard Cox modelSurvival regression modelsCox modelPollution exposureSurvival endpointsCovariates of interest
2009
Power and sample size calculations for longitudinal studies comparing rates of change with a time‐varying exposure
Basagaña X, Spiegelman D. Power and sample size calculations for longitudinal studies comparing rates of change with a time‐varying exposure. Statistics In Medicine 2009, 29: 181-192. PMID: 19899065, PMCID: PMC3772653, DOI: 10.1002/sim.3772.Peer-Reviewed Original Research
2005
Insulin Resistance in HIV-Infected Men and Women in the Nutrition for Healthy Living Cohort
Jones CY, Wilson IB, Greenberg AS, Shevitz A, Knox TA, Gorbach SL, Spiegelman D, Jacobson DL, Wanke C. Insulin Resistance in HIV-Infected Men and Women in the Nutrition for Healthy Living Cohort. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 40: 202-211. PMID: 16186739, DOI: 10.1097/01.qai.0000165910.89462.2f.Peer-Reviewed Original ResearchConceptsQuantitative insulin sensitivity check indexWorse insulin resistancePrevalence of IRInsulin resistanceNHANES IIIHigher high-density lipoproteinInsulin sensitivity check indexNutrition Examination Survey IIIHealthy Living cohortHealthy Living StudyHIV-Infected MenMore insulin resistanceActive antiretroviral therapyCD4 cell countCross-sectional study designInjection drug useLess insulin resistanceExamination Survey IIINHANES III participantsGreater waist circumferenceHigh-density lipoproteinLow-density lipoproteinProtease inhibitorsLiving cohortPI-HAARTPredictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children
Jacobson DL, Spiegelman D, Duggan C, Weinberg GA, Bechard L, Furuta L, Nicchitta J, Gorbach SL, Miller TL. Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children. Journal Of Pediatric Gastroenterology And Nutrition 2005, 41: 339-346. PMID: 16131991, DOI: 10.1097/01.mpg.0000174468.75219.30.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAntiretroviral Therapy, Highly ActiveBlack or African AmericanBody CompositionBody HeightBody Mass IndexBody WeightBone DensityCase-Control StudiesChildChild DevelopmentCross-Sectional StudiesFemaleHispanic or LatinoHIV InfectionsHIV-1HumansLongitudinal StudiesMalePredictive Value of TestsProspective StudiesSeverity of Illness IndexVitaminsWhite PeopleConceptsBMD Z-scoresBone mineral densityLower BMD Z-scoresMineral densityZ-scorePopulation normsMultivitamin useDietary intakePredictors of BMDTotal body bone mineral densityLower weight z-scoreBody bone mineral densityLow bone mineral densitySibling controlsBetter bone mineral densityDual-energy X-ray absorptiometry (DXA) examinationDual-energy X-ray absorptiometryLower height Z-scoresHuman immunodeficiency virus-1Energy X-ray absorptiometryAdvanced HIV stageAge-adjusted percentileIndependent risk factorGender-adjusted z-scoresWeight z-scoreTemporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis
Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D, Ascherio A. Temporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis. JAMA 2005, 293: 2496-2500. PMID: 15914750, DOI: 10.1001/jama.293.20.2496.Peer-Reviewed Original ResearchConceptsViral capsid antigenEpstein-Barr virusMultiple sclerosisAntibody titersEBNA complexRelative riskDevelopment of MSEBV viral capsid antigenEpstein-Barr virus (EBV) antibody titersRisk of MSOnset of MSOnset of symptomsVirus antibody titersSerum antibody titersCase-control studyDefense Serum RepositoryAge 25 yearsBlood sample collectionUS military personnelTemporal relationshipCase-control setsRace/ethnicityAge-dependent relationshipEBV infectionCytomegalovirus antibodiesDietary intake in human immunodeficiency virus–infected adults: A comparison of dietary assessment methods
Hendricks K, Tang A, Spiegelman D, Skinner S, Woods M. Dietary intake in human immunodeficiency virus–infected adults: A comparison of dietary assessment methods. Journal Of The Academy Of Nutrition And Dietetics 2005, 105: 532-540. PMID: 15800553, DOI: 10.1016/j.jada.2005.01.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesDietDiet RecordsDiet SurveysDietary CarbohydratesDietary FatsDietary ProteinsEatingEnergy IntakeEthnicityFemaleHIV InfectionsHumansLongitudinal StudiesMaleMicronutrientsNutrition AssessmentNutrition PolicyRegression AnalysisReproducibility of ResultsSensitivity and SpecificitySurveys and QuestionnairesConceptsFood frequency questionnaireFood recordsDietary Reference IntakesCohort studyDietary intakeLarge cohortReference IntakesIntake dataHuman immunodeficiency virus-infected adultsNutrient intakeHuman immunodeficiency virus (HIV) infectionBlock Food Frequency QuestionnaireImmunodeficiency virus infectionHIV-positive participantsQuintile rankingsLongitudinal cohort studyMean percent agreementOngoing cohort studyProportion of subjectsDietary intake dataDietary assessment methodsNutrient intake dataEstimated nutrient intakeNutrient intake estimatesFrequency questionnaire
2002
Changes in lean body mass and total body weight are weakly associated with physical functioning in patients with HIV infection
Wilson I, Jacobson D, Roubenoff R, Spiegelman D, Knox T, Gorbach S. Changes in lean body mass and total body weight are weakly associated with physical functioning in patients with HIV infection. HIV Medicine 2002, 3: 263-270. PMID: 12444944, DOI: 10.1046/j.1468-1293.2002.00122.x.Peer-Reviewed Original ResearchConceptsTotal body weightSelf-reported physical functioningPhysical functioningHIV infectionBody weightRelationship of changesCells/ micro l.Mean CD4 countHIV-positive personsMain outcome measuresLean body massLongitudinal analysisCD4 countCohort studyPositive personsOutcome measuresHealthy personsBody compositionPatientsStudy designWeight lossMicro l.InfectionWomenHealthy livingRole of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men
Roubenoff R, Grinspoon S, Skolnik PR, Tchetgen E, Abad L, Spiegelman D, Knox T, Gorbach S. Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men. AJP Endocrinology And Metabolism 2002, 283: e138-e145. PMID: 12067854, DOI: 10.1152/ajpendo.00426.2001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntiretroviral Therapy, Highly ActiveBody CompositionBody WeightCD4 Lymphocyte CountCytokinesEnergy MetabolismFollow-Up StudiesHIV InfectionsHIV Wasting SyndromeHumansInterleukin-1Linear ModelsLongitudinal StudiesMaleMiddle AgedNutritional StatusRestTestosteroneThinnessTumor Necrosis Factor-alphaViral LoadConceptsLBM lossPeripheral blood mononuclear cellsIL-1 beta productionWeight lossActive antiretroviral therapyCohort of patientsSerum free testosteroneBlood mononuclear cellsInadequate dietary intakeOngoing cohort studyCytokine tumor necrosisRole of cytokinesIL-1 betaTNF-alpha productionInterleukin-1 betaMo of observationLean body massKcal/dayAntiretroviral therapyCohort studyFree testosteroneHIV infectionIndependent predictorsCytokine productionMononuclear cells
2001
The correlates of dietary intake among HIV-positive adults 1 , 2 , 3
Kim J, Spiegelman D, Rimm E, Gorbach S. The correlates of dietary intake among HIV-positive adults 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 74: 852-861. PMID: 11722969, DOI: 10.1093/ajcn/74.6.852.Peer-Reviewed Original ResearchConceptsHigher energy intakeDietary intakeEnergy intakeHIV infectionClinical outcomesDietary adequacyAdverse clinical outcomesAbsence of nauseaInadequate dietary intakeInadequate protein intakeInadequate energy intakeInjection drug usersCross-sectional studyStudy cohortFemale sexDiet recordsReduced appetiteDietary inadequacyStudy populationProtein intakeDietary allowanceDrug usersDiverse cohortIntakeWeight lossPredictors of airborne endotoxin in the home.
Park JH, Spiegelman DL, Gold DR, Burge HA, Milton DK. Predictors of airborne endotoxin in the home. Environmental Health Perspectives 2001, 109: 859-864. PMID: 11564624, PMCID: PMC1240416, DOI: 10.1289/ehp.01109859.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir Pollution, IndoorAllergensAnimalsAnimals, DomesticAsthmaCatsDogsDustEndotoxinsEnvironmental MonitoringEpidemiological MonitoringHousingHumansHumidityHypersensitivityInfantLongitudinal StudiesMassachusettsMiceModels, StatisticalMultivariate AnalysisPredictive Value of TestsRegression AnalysisSeasonsTobacco Smoke PollutionIntakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women
Zhang SM, Hernán MA, Olek MJ, Spiegelman D, Willett WC, Ascherio A. Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women. Neurology 2001, 57: 75-80. PMID: 11445631, DOI: 10.1212/wnl.57.1.75.Peer-Reviewed Original ResearchConceptsRisk of MSVitamin EVitamin CLarge cohortSemiquantitative food frequency questionnaireRecent case-control studyAssociation of intakeMultivariate relative riskVitamin C intakeFood frequency questionnaireIntake of carotenoidsIntake of fruitsDietary vitamin CTotal energy intakeDietary vitamin E.Case-control studyLutein/zeaxanthinCases of MSFrequency questionnaireC intakeMS riskMultivitamin supplementsAntioxidant nutrientsHighest quintileLowest quintileWeight and body composition in a cohort of HIV-positive men and women
Forrester J, Spiegelman D, Woods M, Knox T, Fauntleroy J, Gorbach S. Weight and body composition in a cohort of HIV-positive men and women. Public Health Nutrition 2001, 4: 743-747. PMID: 11415480, DOI: 10.1079/phn200099.Peer-Reviewed Original Research
2000
Predictors of Change in the Functional Status of Children With Human Immunodeficiency Virus Infection
Missmer S, Spiegelman D, Gorbach S, Miller T. Predictors of Change in the Functional Status of Children With Human Immunodeficiency Virus Infection. Pediatrics 2000, 106: e24-e24. PMID: 10920180, DOI: 10.1542/peds.106.2.e24.Peer-Reviewed Original ResearchConceptsHeight z-scoreHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionTotal health scoreFunctional statusHealth scoresZ-scoreGeneral healthVirus infectionBaseline evaluationCD4 T-lymphocyte countFunctional status parametersFunctional status surveyHIV disease stageT-lymphocyte countsAbsolute CD4 countGeneral health scoresImportant clinical predictorsSignificant univariate predictorsFunctional status scoresMain outcome measuresNon-white raceResponsiveness scoresPredictors of changeCD4 countRelation of lean body mass to health-related quality of life in persons with HIV.
Wilson I, Roubenoff R, Knox T, Spiegelman D, Gorbach S. Relation of lean body mass to health-related quality of life in persons with HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 137-46. PMID: 10935689, DOI: 10.1097/00126334-200006010-00008.Peer-Reviewed Original ResearchConceptsGeneral health perceptionPhysical functionHealth-related qualityLean body massHigher lean body massHealth perceptionAssociated with better physical functionClinical impact of interventionsHealth-related quality of lifeDiverse population of personsBioimpedance analysisPatient self-reportBody massImpact of interventionsPopulation of personsCross-sectional analysisQuality of lifeIncreased LBMSelf-reportDiverse populationsEnergy/fatigueMultivariate modelHIVCD4 countHIV infectionRelation of Lean Body Mass to Health-Related Quality of Life in Persons With HIV
Wilson I, Roubenoff R, Knox T, Spiegelman D, Gorbach S. Relation of Lean Body Mass to Health-Related Quality of Life in Persons With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 137-146. DOI: 10.1097/00042560-200006010-00008.Peer-Reviewed Original ResearchConceptsLean body massHigher lean body massGeneral health perceptionEnergy/fatiguePhysical functioningHealth perceptionBetter general health perceptionBioimpedance analysisDesign Cross-sectional analysisMeasures of HRQLHealth-related qualityBody massLast monthBetter physical functioningQuality of lifeCross-sectional analysisCD4 countHIV infectionMean ageClinical impactMultivariable modelHIVCells/Number of daysWomen
1998
The effect of protease inhibitors on weight and body composition in HIV-infected patients
Silva M, Skolnik P, Gorbach S, Spiegelman D, Wilson I, Fernández-DiFranco M, Knox T. The effect of protease inhibitors on weight and body composition in HIV-infected patients. AIDS 1998, 12: 1645-1651. PMID: 9764784, DOI: 10.1097/00002030-199813000-00012.Peer-Reviewed Original ResearchConceptsLean body massPI therapyHIV infectionWeight gainViral loadPhysical functioningHealth perceptionBody compositionCurrent health perceptionsActive antiretroviral therapyPI treatmentProtease inhibitor therapyBody mass indexGreater weight gainHuman growth hormoneAntiretroviral therapyHIV cohortBody massInhibitor therapyMass indexOptimal therapyFat massAnabolic stimuliPatientsGrowth hormonePredictors of level of circulating abnormal lymphocytes among human T‐lymphotropic virus type I carriers in Japan
Hisada M, Okayama A, Tachibana N, Stuver S, Spiegelman D, Tsubouchi H, Mueller N. Predictors of level of circulating abnormal lymphocytes among human T‐lymphotropic virus type I carriers in Japan. International Journal Of Cancer 1998, 77: 188-192. PMID: 9650550, DOI: 10.1002/(sici)1097-0215(19980717)77:2<188::aid-ijc3>3.0.co;2-m.Peer-Reviewed Original ResearchConceptsHuman T-lymphotropic virus type I carriersAdult T-cell leukemiaHigh proviral loadAbnormal lymphocytesProviral loadI carriersAsymptomatic HTLV-I carriersHTLV-I carriersT-cell leukemiaMale genderMultivariate analysisMalignant cellsBlood smearsPredictors of levelsLongitudinal studyLymphocytesPredictorsHTLVLeukemiaLevelsSmears
1994
Human adiposeα-tocopherol andγ-tocopherol kinetics during and after 1 y ofα-tocopherol supplementation
Handelman G, Epstein W, Peerson J, Spiegelman D, Machlin L, Dratz E. Human adiposeα-tocopherol andγ-tocopherol kinetics during and after 1 y ofα-tocopherol supplementation. American Journal Of Clinical Nutrition 1994, 59: 1025-1032. PMID: 8172086, DOI: 10.1093/ajcn/59.5.1025.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueCholesterolCross-Sectional StudiesHumansKineticsLongitudinal StudiesMaleTriglyceridesVitamin EConceptsAlpha-tocopherol intakeAlpha-tocopherolGamma-tocopherolTocopherol/dLong-term useSupplement useTocopherol ratioNeedle biopsySupplementation periodSupplementation trialTocopherol supplementCross-sectional measurementsHuman AdiposeAdditional yearIntakeSupplementationConsistent decreaseSupplementsSubjectsBiopsyGammaTrials