2011
Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study
Wu J, Lemaitre RN, Imamura F, King IB, Song X, Spiegelman D, Siscovick DS, Mozaffarian D. Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study. American Journal Of Clinical Nutrition 2011, 94: 431-438. PMID: 21697077, PMCID: PMC3142722, DOI: 10.3945/ajcn.111.012054.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseNonfatal myocardial infarctionSudden cardiac arrestFatal coronary heart diseaseTotal coronary heart diseaseIncident coronary heart diseaseDe novo lipogenesisHigh riskCHD eventsHeart diseaseMultivariable-adjusted Cox proportional hazardsCommunity-based prospective studySecondary analysisCardiovascular disease risk factorsCardiovascular Health StudyDisease risk factorsFatty acidsCox proportional hazardsDe novo lipogenesis pathwayCHD deathCHD outcomesProspective studyCardiac arrestMyocardial infarctionMedical records
2005
Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status
Hines LM, Hunter DJ, Stampfer MJ, Spiegelman D, Chu NF, Rifai N, Hankinson SE, Rimm EB. Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status. Atherosclerosis 2005, 182: 293-300. PMID: 16051248, DOI: 10.1016/j.atherosclerosis.2005.02.005.Peer-Reviewed Original ResearchConceptsHigh-density lipoprotein levelsPostmenopausal hormonesPostmenopausal womenModerate alcohol consumptionHDL levelsOlder-aged menPremenopausal womenAlcohol consumptionADH1C genotypeLipoprotein levelsAged menCoronary heart diseaseMenopausal statusExogenous estrogenMyocardial infarctionHeart diseaseModerate drinkersOlder menFunctional polymorphismsWomenType 1CMenVaried exposureAssociationHigh levels
2004
Physical activity and risk of coronary heart disease in India
Rastogi T, Vaz M, Spiegelman D, Reddy KS, Bharathi A, Stampfer MJ, Willett WC, Ascherio A. Physical activity and risk of coronary heart disease in India. International Journal Of Epidemiology 2004, 33: 759-767. PMID: 15044412, DOI: 10.1093/ije/dyh042.Peer-Reviewed Original ResearchConceptsLeisure-time exerciseCHD riskRisk factorsPhysical activityPhysical exerciseSedentary activitiesHospital-based case-control studyCoronary heart disease riskDisease riskHeart disease riskCoronary heart diseaseAcute myocardial infarctionRisk of CHDSex-adjusted analysesCase-control studyConditional logistic regressionPhysical inactivity levelsMultivariate adjustmentBrisk walkingMyocardial infarctionHeart diseaseRelative riskSedentary lifestyleElevated riskMultivariate analysisDiet and risk of ischemic heart disease in India
Rastogi T, Reddy KS, Vaz M, Spiegelman D, Prabhakaran D, Willett WC, Stampfer MJ, Ascherio A. Diet and risk of ischemic heart disease in India. American Journal Of Clinical Nutrition 2004, 79: 582-592. PMID: 15051601, DOI: 10.1093/ajcn/79.4.582.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseServings/wkIHD riskLower riskHeart diseaseInverse associationHospital-based case-control studyDose-dependent inverse associationLong-term dietary intakeFood frequency questionnaireAcute myocardial infarctionCase-control studyConditional logistic regressionPredictors of riskLower relative riskAlpha-linolenic acidBasis of ageMustard oilGreen leafy vegetablesMyocardial infarctionVegetable intakeLeading causeDietary intakeCereal intakeRelative riskDietary Fiber and Risk of Coronary Heart Disease: A Pooled Analysis of Cohort Studies
Pereira MA, O'Reilly E, Augustsson K, Fraser GE, Goldbourt U, Heitmann BL, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A. Dietary Fiber and Risk of Coronary Heart Disease: A Pooled Analysis of Cohort Studies. JAMA Internal Medicine 2004, 164: 370-376. PMID: 14980987, DOI: 10.1001/archinte.164.4.370.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseDietary fiber intakeHeart diseaseFiber intakeCoronary deathCoronary eventsCohort studyPooled analysisD incrementDietary fiberVegetable fiber intakeProspective cohort studyBody mass indexSex-specific resultsMass indexLifestyle factorsCoronary casesEpidemiologic studiesDiseaseIntakeDeathRiskWomenTotal dietary fiberMen
2003
Dietary Fiber Reduces Peripheral Arterial Disease Risk in Men
Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A. Dietary Fiber Reduces Peripheral Arterial Disease Risk in Men. Journal Of Nutrition 2003, 133: 3658-3663. PMID: 14608090, DOI: 10.1093/jn/133.11.3658.Peer-Reviewed Original ResearchConceptsPeripheral arterial disease riskCereal fiber intakeArterial disease riskPAD riskFiber intakeInverse associationDisease riskEarly coronary heart diseaseIncident PAD casesFood frequency questionnaireCoronary heart diseaseTotal fiber intakeOverall inverse associationDisease QuestionnaireFrequency questionnaireLowest quintileHeart diseaseCardiovascular diseaseFamily historyPhysical activityPAD casesAlcohol consumptionEnergy intakeIntakeRiskThe Use of B Vitamin Supplements and Peripheral Arterial Disease Risk in Men Are Inversely Related
Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A. The Use of B Vitamin Supplements and Peripheral Arterial Disease Risk in Men Are Inversely Related. Journal Of Nutrition 2003, 133: 2863-2867. PMID: 12949378, DOI: 10.1093/jn/133.9.2863.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseasePAD riskFolate intakePrevention of PADPeripheral arterial disease riskVitamin BArterial disease riskIncident PAD casesU.S. health professionalsB vitamin intakeVitamin supplement useB-vitamin supplementsCoronary heart diseaseWeak inverse associationMultivariate adjustmentArterial diseaseVitamin intakeSupplement useHeart diseaseInverse associationCardiovascular diseaseD incrementStudy populationVitamin supplementsDietary folateVitamin C and risk of coronary heart disease in women
Osganian SK, Stampfer MJ, Rimm E, Spiegelman D, Hu FB, Manson JE, Willett WC. Vitamin C and risk of coronary heart disease in women. Journal Of The American College Of Cardiology 2003, 42: 246-252. PMID: 12875759, DOI: 10.1016/s0735-1097(03)00575-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAntioxidantsAscorbic AcidChemopreventionCoronary DiseaseDiabetes ComplicationsDietary SupplementsFemaleHumansHypercholesterolemiaHypertensionIncidenceLife StyleLogistic ModelsMiddle AgedMultivariate AnalysisNutrition SurveysProportional Hazards ModelsProspective StudiesRisk FactorsSmokingSurveys and QuestionnairesUnited StatesWomen's HealthConceptsRisk of CHDCoronary heart diseaseVitamin C intakeCoronary risk factorsVitamin C supplementsC intakeVitamin CC supplementsHeart diseaseRisk factorsLower riskDetailed semiquantitative food frequency questionnaireIncidence of CHDVitamin C supplement useIncident coronary heart diseaseSemiquantitative food frequency questionnaireFood frequency questionnaireSignificant inverse associationIncident casesSupplement useProspective InvestigationInverse associationProtective associationFemale nursesTotal intakeHigh 18:2 Trans-Fatty Acids in Adipose Tissue Are Associated with Increased Risk of Nonfatal Acute Myocardial Infarction in Costa Rican Adults
Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H. High 18:2 Trans-Fatty Acids in Adipose Tissue Are Associated with Increased Risk of Nonfatal Acute Myocardial Infarction in Costa Rican Adults. Journal Of Nutrition 2003, 133: 1186-1191. PMID: 12672941, DOI: 10.1093/jn/133.4.1186.Peer-Reviewed Original ResearchConceptsRisk of MICoronary heart diseaseMyocardial infarctionAdipose tissueTrans fatty acidsOdds ratioNonfatal acute myocardial infarctionTrans fatty acid intakeFirst nonfatal myocardial infarctionConditional logistic regression modelsNonfatal myocardial infarctionTrans FACosta Rican adultsAcute myocardial infarctionTotal adipose tissueAdipose tissue samplesArea of residenceIndividual trans fatty acidsLogistic regression modelsIncreased riskIncident casesAcid intakeRisk factorsAtherogenic potentialHeart disease
2002
Mercury and the Risk of Coronary Heart Disease in Men
Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh CC, Spiegelman D, Stampfer MJ, Willett WC. Mercury and the Risk of Coronary Heart Disease in Men. New England Journal Of Medicine 2002, 347: 1755-1760. PMID: 12456851, DOI: 10.1056/nejmoa021437.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart diseaseMale health professionalsHigh dietary intakeYears of ageCase-control designMercury levelsSmoking statusTotal mercury exposureControl subjectsLowest quintileRisk factorsDietary intakeCardiovascular diseaseRelative riskCohort membersPrevious historyToenail clippingsHealth professionalsDiseaseConsumption of fishMercury exposureMean mercury levelRiskFish consumptionDietary and Adipose Tissue Gamma-Tocopherol and Risk of Myocardial Infarction
El-Sohemy A, Baylin A, Spiegelman D, Ascherio A, Campos H. Dietary and Adipose Tissue Gamma-Tocopherol and Risk of Myocardial Infarction. Epidemiology 2002, 13: 216-223. PMID: 11880764, DOI: 10.1097/00001648-200203000-00018.Peer-Reviewed Original ResearchConceptsDietary vitamin EMyocardial infarctionGamma-tocopherolOdds ratioVitamin ENonfatal myocardial infarctionFood frequency questionnaireCoronary heart diseasePopulation-based studyFirst myocardial infarctionConfidence intervalsConditional logistic regressionAdipose tissue samplesHighest quintileSupplement usersLowest quintileHeart diseaseInverse associationDietary intakeLower riskSubstantial inverse associationMultivariate analysisLogistic regressionTissue samplesWeak association
2001
The effect of fruit and vegetable intake on risk for coronary heart disease.
Joshipura K, Hu F, Manson J, Stampfer M, Rimm E, Speizer F, Colditz G, Ascherio A, Rosner B, Spiegelman D, Willett W. The effect of fruit and vegetable intake on risk for coronary heart disease. Annals Of Internal Medicine 2001, 134: 1106-14. PMID: 11412050, DOI: 10.7326/0003-4819-134-12-200106190-00010.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart diseaseVegetable intakeGreen leafy vegetablesProtective effectHealth StudyVegetable consumptionFatal coronary heart diseaseStandard cardiovascular risk factorsVitamin CCardiovascular risk factorsNonfatal myocardial infarctionNurses' Health StudyProspective cohort studyFood frequency questionnaireIntake of fruitsRich fruitsMain outcome measuresApparent protective effectAssociation of fruitYears of ageConsumption of fruitsEffect of fruitConstituents of fruitsMen 40
2000
Adherence to the Dietary Guidelines for Americans and risk of major chronic disease in men 1 , 2 , 3 , 4 , 5
McCullough M, Feskanich D, Rimm E, Giovannucci E, Ascherio A, Variyam J, Spiegelman D, Stampfer M, Willett W. Adherence to the Dietary Guidelines for Americans and risk of major chronic disease in men 1 , 2 , 3 , 4 , 5. American Journal Of Clinical Nutrition 2000, 72: 1223-1231. PMID: 11063453, DOI: 10.1093/ajcn/72.5.1223.Peer-Reviewed Original ResearchConceptsMajor chronic diseasesChronic diseasesFood Guide PyramidDietary guidelinesCardiovascular diseaseLower riskIncident major cardiovascular diseaseUS male health professionalsMale health professionalsFood frequency questionnaireChronic disease outcomesHigher HEI scoresMajor cardiovascular diseasesLower cancer riskHEI scoresHeart diseaseRisk factorsDietary patternsDisease outcomeFood intakeCancer riskHealth professionalsMEN 1Detailed questionnaireDiseaseProspective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3
Hu F, Rimm E, Stampfer M, Ascherio A, Spiegelman D, Willett W. Prospective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3. American Journal Of Clinical Nutrition 2000, 72: 912-921. PMID: 11010931, DOI: 10.1093/ajcn/72.4.912.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAlcohol DrinkingBody Mass IndexCohort StudiesCoronary DiseaseDietDiet RecordsDietary SupplementsExerciseFactor Analysis, StatisticalHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProportional Hazards ModelsProspective StudiesRisk FactorsSmokingSurveys and QuestionnairesConceptsCoronary heart diseaseFood frequency questionnaireMajor dietary patternsRisk of CHDDietary patternsHeart diseaseRelative riskHigh intakePattern scoresCases of CHDHigh-fat dairy productsPrudent pattern scoresWestern pattern scoreCHD risk factorsProspective cohort studyOverall dietary patternsBody mass indexPrudent patternCohort studyCigarette smokingMass indexProspective studyHighest quintileMyocardial infarctionSubgroup analysis
1999
Effects of Long‐Acting Versus Short‐Acting Calcium Channel Blockers Among Older Survivors of Acute Myocardial Infarction
Gillman M, Ross‐Degnan D, McLaughlin T, Gao X, Spiegelman D, Hertzmark E, Goldman L, Soumerai S. Effects of Long‐Acting Versus Short‐Acting Calcium Channel Blockers Among Older Survivors of Acute Myocardial Infarction. Journal Of The American Geriatrics Society 1999, 47: 512-517. PMID: 10323641, DOI: 10.1111/j.1532-5415.1999.tb02562.x.Peer-Reviewed Original ResearchConceptsCalcium channel blockersAcute myocardial infarctionShort-acting calcium channel blockersCardiac rehospitalizationMyocardial infarctionChannel blockersRelative riskOlder survivorsActing calcium channel blockerSeparate Cox regression modelsDihydropyridine calcium channel blockerRetrospective cohort studyCoronary heart diseaseDrug claims dataCox regression modelDrug benefit programCause mortalityClinical characteristicsCohort studyEligible subjectsRehospitalization ratesAdverse outcomesHeart diseaseOutcome measuresRehospitalizationDietary Fat and Coronary Heart Disease: A Comparison of Approaches for Adjusting for Total Energy Intake and Modeling Repeated Dietary Measurements
Hu F, Stampfer M, Rimm E, Ascherio A, Rosner B, Spiegelman D, Willett W. Dietary Fat and Coronary Heart Disease: A Comparison of Approaches for Adjusting for Total Energy Intake and Modeling Repeated Dietary Measurements. American Journal Of Epidemiology 1999, 149: 531-540. PMID: 10084242, DOI: 10.1093/oxfordjournals.aje.a009849.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseRisk of CHDTotal energy intakeNutrient density modelsBaseline dietHeart diseaseHigh intakeHealth StudyDietary measurementsEnergy intakeMultivariate nutrient density modelsPrevious cohort studiesNurses' Health StudyAssessment of dietEnergy adjustment methodCohort studyEnergy adjustmentFat intakeDietary fatRelative riskRecent dietDietary assessmentIntakeTrans fatsMultivariate model
1998
Use of Toenail Fluoride Levels as an Indicator for the Risk of Hip and Forearm Fractures in Women
Feskanich D, Owusu W, Hunter D, Willett W, Ascherio A, Spiegelman D, Morris S, Spate V, Colditz G. Use of Toenail Fluoride Levels as an Indicator for the Risk of Hip and Forearm Fractures in Women. Epidemiology 1998, 9: 412-416. PMID: 9647905, DOI: 10.1097/00001648-199807000-00011.Peer-Reviewed Original ResearchConceptsForearm fracturesFluoride intakeOdds ratioHealth StudyVitamin D intakeDistal forearm fracturesNurses' Health StudyRisk of hipPostmenopausal hormone useBody mass indexLong-term intakeYear of birthD intakeMenopausal statusHip fractureHormone useHighest quartileMass indexOsteoporotic fracturesSmoking statusPrevious hipHeart diseaseSubsequent riskCaffeine intakeEpidemiologic studies
1997
A Prospective Study of Oral Contraceptives and NIDDM Among U.S. Women
Chasan-Taber L, Willett W, Stampfer M, Hunter D, Colditz G, Spiegelman D, Manson J. A Prospective Study of Oral Contraceptives and NIDDM Among U.S. Women. Diabetes Care 1997, 20: 330-335. PMID: 9051382, DOI: 10.2337/diacare.20.3.330.Peer-Reviewed Original ResearchConceptsOral contraceptivesRelative riskPast usersProspective studyModern oral contraceptivesU.S. female nursesMultivariate relative riskOral contraceptive useProspective cohort studyLarge prospective studiesLow absolute riskCoronary heart diseaseCurrent usersHistory of diagnosisDiagnosed diabetesCohort studyElevated cholesterolAlcohol intakeCigarette smokingIncident casesSymptomatic casesAbsolute riskExcess riskHeart diseaseFamily history
1996
Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States
Ascherio A, Rimm E, Giovannucci E, Spiegelman D, Meir S, Willett W. Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. The BMJ 1996, 313: 84. PMID: 8688759, PMCID: PMC2351515, DOI: 10.1136/bmj.313.7049.84.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart diseaseMyocardial infarctionFat intakeRisk factorsHealth professionalsFatal coronary heart diseaseNon-dietary risk factorsNon-fatal myocardial infarctionCohort questionnaire studyCoronary risk factorsMultivariate relative riskTotal fat intakeIntake of cholesterolAcute myocardial infarctionDiagnosed cardiovascular diseaseLinolenic acid intakeBlood cholesterol concentrationsIntake of fiberPositive associationCoronary deathCoronary eventsSpecific preventive effectCholesterol intakeCoronary diseaseVegetable, Fruit, and Cereal Fiber Intake and Risk of Coronary Heart Disease Among Men
Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC. Vegetable, Fruit, and Cereal Fiber Intake and Risk of Coronary Heart Disease Among Men. JAMA 1996, 275: 447-451. PMID: 8627965, DOI: 10.1001/jama.1996.03530300031036.Peer-Reviewed Original ResearchConceptsTotal myocardial infarctionCoronary heart diseaseDietary fiber intakeMyocardial infarctionFiber intakeRelative riskCoronary diseaseHeart diseaseInverse associationCases of MIAge-adjusted relative riskTotal dietary fiber intakeDietary fiberCereal fiber intakeCardiovascular risk factorsNonfatal myocardial infarctionTotal energy intakeTotal fiber intakeCurrent national dietary guidelinesMain food contributorsFatal coronary diseaseYears of ageNational dietary guidelinesDietary questionnaireCohort study