Epstein-Barr Virus Antibodies and Risk of Multiple Sclerosis: A Prospective Study
Ascherio A, Munger KL, Lennette ET, Spiegelman D, Hernán MA, Olek MJ, Hankinson SE, Hunter DJ. Epstein-Barr Virus Antibodies and Risk of Multiple Sclerosis: A Prospective Study. JAMA 2001, 286: 3083-3088. PMID: 11754673, DOI: 10.1001/jama.286.24.3083.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusViral capsid antigenCases of MSGeometric mean titersHealth Study IIMultiple sclerosisSerum antibody titersRelative riskAntibody titersDisease onsetEBNA-2Health StudyRole of EBVNurses' Health Study IIEBV viral capsid antigenEpstein-Barr virus antibodiesEtiology of MSOccurrence of MSHealthy age-matched controlsNurses' Health StudyCorresponding relative risksCase-control studyAge-matched controlsCMV antigensEBV antibodiesIntakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women
Zhang SM, Hernán MA, Olek MJ, Spiegelman D, Willett WC, Ascherio A. Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women. Neurology 2001, 57: 75-80. PMID: 11445631, DOI: 10.1212/wnl.57.1.75.Peer-Reviewed Original ResearchConceptsRisk of MSVitamin EVitamin CLarge cohortSemiquantitative food frequency questionnaireRecent case-control studyAssociation of intakeMultivariate relative riskVitamin C intakeFood frequency questionnaireIntake of carotenoidsIntake of fruitsDietary vitamin CTotal energy intakeDietary vitamin E.Case-control studyLutein/zeaxanthinCases of MSFrequency questionnaireC intakeMS riskMultivitamin supplementsAntioxidant nutrientsHighest quintileLowest quintile