Reciprocal Alterations in Regulator of G Protein Signaling 4 and microRNA16 in Schizophrenia
Kimoto S, Glausier J, Fish K, Volk D, Bazmi H, Arion D, Datta D, Lewis D. Reciprocal Alterations in Regulator of G Protein Signaling 4 and microRNA16 in Schizophrenia. Schizophrenia Bulletin 2015, 42: 396-405. PMID: 26424323, PMCID: PMC4753606, DOI: 10.1093/schbul/sbv139.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansMaleMicroRNAsMiddle AgedPrefrontal CortexPsychotic DisordersRGS ProteinsRNA, MessengerSchizophreniaSignal TransductionConceptsG protein-coupled receptorsDorsolateral prefrontal cortexG Protein Signaling 4Schizophrenia subjectsRGS4 mRNANMDAR hypofunctionNMDAR activityProtein levelsN-methyl-D-aspartate (NMDA) receptor hypofunctionRole of RGS4Pathology of schizophreniaHealthy comparison subjectsRGS4 mRNA levelsLevels of miR16RGS4 levelsProtein-coupled receptorsPyramidal neuronsReceptor hypofunctionPyramidal cellsComparison subjectsIncreased expressionHypofunctionPrefrontal cortexSchizophreniaMRNA levelsDistinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder
Arion D, Corradi J, Tang S, Datta D, Boothe F, He A, Cacace A, Zaczek R, Albright C, Tseng G, Lewis D. Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder. Molecular Psychiatry 2015, 20: 1397-1405. PMID: 25560755, PMCID: PMC4492919, DOI: 10.1038/mp.2014.171.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnimalsAntipsychotic AgentsFemaleGene Expression ProfilingGene Expression RegulationHumansLaser Capture MicrodissectionMacaca fascicularisMaleMiddle AgedMitochondrial ProteinsOligonucleotide Array Sequence AnalysisPrefrontal CortexPsychotic DisordersPyramidal CellsRNA, MessengerSchizophreniaSignal TransductionTranscriptomeUbiquitin