2020
Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau
Leslie SN, Datta D, Christensen KR, van Dyck CH, Arnsten AFT, Nairn AC. Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau. Frontiers In Aging Neuroscience 2020, 12: 576723. PMID: 33192469, PMCID: PMC7655962, DOI: 10.3389/fnagi.2020.576723.Peer-Reviewed Original ResearchFrontal association cortexAged ratsAlzheimer's diseaseAD tau pathologyAD-related sitesAge-related lossMemory-enhancing effectsLargest risk factorPhosphorylation of tauAge-related changesTau dissociationTau pathologyRisk factorsTau hyperphosphorylationFrontal cortexHealthy individualsTherapeutic targetAssociation cortexCognitive impairmentGEBR-7bBrain regionsRodent hippocampusPotassium channelsPhosphodiesterase 4DRats
2012
Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis Patients
Harberts E, Datta D, Chen S, Wohler J, Oh U, Jacobson S. Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis Patients. Journal Of Neuroimmune Pharmacology 2012, 8: 51-57. PMID: 22956240, PMCID: PMC4765953, DOI: 10.1007/s11481-012-9397-5.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdultBiomarkersBrainCell SeparationFemaleHumansIsoquinolinesLeukocytes, MononuclearLipopolysaccharide ReceptorsMagnetic Resonance ImagingMaleMembrane Potential, MitochondrialMiddle AgedMitochondriaMultiple SclerosisPositron-Emission TomographyProtein BindingPyridinesRadioligand AssayRadiopharmaceuticalsReal-Time Polymerase Chain ReactionReceptors, GABAConceptsPeripheral blood mononuclear cellsMultiple sclerosis patientsExpression of TSPOMagnetic resonance imagingPositron emission tomographyTSPO expressionSclerosis patientsCentral nervous system inflammationHealthy donor cohortNervous system inflammationMarkers of inflammationPotential peripheral biomarkerBlood mononuclear cellsTranslocator protein 18TSPO protein expressionSystem inflammationMS patientsNeuroinflammatory conditionsPeripheral biomarkersMononuclear cellsNeuropathologic conditionsDonor cohortInflammatory diseasesHealthy donorsHealthy individuals