2010
Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists
Krystal JH, Mathew SJ, D’Souza D, Garakani A, Gunduz-Bruce H, Charney DS. Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists. CNS Drugs 2010, 24: 669-693. PMID: 20658799, DOI: 10.2165/11533230-000000000-00000.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPreliminary clinical trialsPositive allosteric modulatorsPsychiatric disordersClinical trialsAnimal modelsAllosteric modulatorsGroup II mGluR agonistGroup IMetabotropic glutamate receptor agonistAnxiety disordersPotential psychiatric applicationsGlutamate receptor agonistsMetabotropic glutamate receptorsTreatment of schizophreniaRole of glutamateForm of depressionMGluR agonistAntidepressant propertiesMGluR5 agonistReceptor agonistGlutamate receptorsMood disordersArea of schizophreniaPromising agentAgonists
1997
Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans
Laruelle M, D’Souza C, Baldwin R, Abi-Dargham A, Kanes S, Fingado C, Seibyl J, Zoghbi S, Bowers M, Jatlow P, Charney D, Innis R. Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans. Neuropsychopharmacology 1997, 17: 162-174. PMID: 9272483, DOI: 10.1016/s0893-133x(97)00043-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectAlpha-MethyltyrosineAnimalsBenzamidesBrainDopamineEnzyme InhibitorsHomovanillic AcidHumansIodine RadioisotopesMaleMethoxyhydroxyphenylglycolParkinson Disease, SecondaryPyrrolidinesRatsRats, Sprague-DawleyReceptors, Dopamine D2Tomography, Emission-Computed, Single-PhotonTyrosine 3-MonooxygenaseConceptsAcute dopamine depletionSynaptic dopamine concentrationsEndogenous dopamineDopamine depletionPositron emission tomographyD2 receptorsTyrosine hydroxylase inhibitor alpha-methylDopamine concentrationsD2 receptor imagingD2 receptor upregulationD2 receptor occupancySingle photon emissionPara-tyrosineReceptor upregulationReceptor imagingAlpha-methylReceptor occupancyEmission tomographyDopaminePhoton emissionHuman brainReceptorsTomographyRodentsVivo measurements