2021
Association of Cannabis Use During Adolescence With Neurodevelopment
Albaugh MD, Ottino-Gonzalez J, Sidwell A, Lepage C, Juliano A, Owens MM, Chaarani B, Spechler P, Fontaine N, Rioux P, Lewis L, Jeon S, Evans A, D’Souza D, Radhakrishnan R, Banaschewski T, Bokde ALW, Quinlan EB, Conrod P, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot M, Nees F, Orfanos D, Paus T, Poustka L, Millenet S, Fröhner JH, Smolka MN, Walter H, Whelan R, Schumann G, Potter A, Garavan H. Association of Cannabis Use During Adolescence With Neurodevelopment. JAMA Psychiatry 2021, 78: 1031-1040. PMID: 34132750, PMCID: PMC8209561, DOI: 10.1001/jamapsychiatry.2021.1258.Peer-Reviewed Original ResearchCannabis useAltered neurodevelopmentAge-related cortical thinningBaseline cortical thicknessAge-related thinningDose-dependent fashionRight prefrontal cortexMR imagesEuropean School Survey ProjectCortical thickness developmentCohort studyCortical thinningStudy baselineCIVET pipelineEndocannabinoid signalingMAIN OUTCOMECortical thicknessAdolescent brain developmentAnimal studiesSignificant associationBrain developmentPrefrontal cortexAdolescent brainBehavioral effectsCortex
2015
Δ9-THC Disrupts Gamma (γ)-Band Neural Oscillations in Humans
Cortes-Briones J, Skosnik PD, Mathalon D, Cahill J, Pittman B, Williams A, Sewell RA, Ranganathan M, Roach B, Ford J, D'Souza DC. Δ9-THC Disrupts Gamma (γ)-Band Neural Oscillations in Humans. Neuropsychopharmacology 2015, 40: 2124-2134. PMID: 25709097, PMCID: PMC4613601, DOI: 10.1038/npp.2015.53.Peer-Reviewed Original ResearchConceptsAuditory steady-state responseΔ9-THCHz stimulationIntertrial coherenceDose-related effectsNeural oscillationsNegative Syndrome ScalePsychophysiological alterationsAcute effectsPsychotic disordersAnimal studiesSyndrome ScalePANSS subscalesRecent usersBehavioral effectsTotal scoreEvoked powerCannabinoidsCounterbalanced designTrend levelΓ oscillationsTest dayBand oscillationsHz conditionStimulation