2005
Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study
Modi W, Scott K, Goedert J, Vlahov D, Buchbinder S, Detels R, Donfield S, O'Brien S, Winkler C. Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study. Genes & Immunity 2005, 6: 691-698. PMID: 16177829, DOI: 10.1038/sj.gene.6364258.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAllelesBlack or African AmericanChemokine CXCL12Chemokines, CXCChildCohort StudiesDisease ProgressionFemaleGene FrequencyHaplotypesHIV InfectionsHIV-1HumansLongitudinal StudiesMaleOdds RatioPolymorphism, Single NucleotideRisk FactorsSurvival AnalysisUnited StatesWhite PeopleConceptsSDF-1 geneCohort studySingle nucleotide polymorphismsAfrican AmericansOnly natural ligandSingle disease outcomesX4 HIV-1HIV-1 infectionAIDS Cohort StudyRisk of infectionMACS cohortDisease outcomeHIV-1Epidemiological studiesSDF-1Significant associationChemokine genesInfectionRs1801157Natural ligandProgressionHaplotype analysisCommon haplotypeCXCR4Cohort
2004
Club Drug Use Among Minority Substance Users in New York City
Ompad D, Galea S, Fuller C, Phelan D, Vlahov D. Club Drug Use Among Minority Substance Users in New York City. Journal Of Psychoactive Drugs 2004, 36: 397-399. PMID: 15559686, DOI: 10.1080/02791072.2004.10400039.Peer-Reviewed Original ResearchAn analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection
Thio C, Goedert J, Mosbruger T, Vlahov D, Strathdee S, O'Brien S, Astemborski J, Thomas D. An analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection. Genes & Immunity 2004, 5: 294-300. PMID: 15071492, DOI: 10.1038/sj.gene.6364072.Peer-Reviewed Original ResearchConceptsHepatitis C virus infectionC virus infectionHuman leukocyte antigenHCV infectionSingle nucleotide polymorphismsVirus infectionBlack subjectsTumor Necrosis Factor-α Gene PolymorphismsNecrosis factor-α gene polymorphismsCytokine tumor necrosis factor alphaTNF single nucleotide polymorphismsTumor necrosis factor alphaRole of TNFFunction of TNFΑ gene polymorphismsNecrosis factor alphaCohort of individualsHCV outcomesHCV clearanceViral clearanceLeukocyte antigenViral persistenceFactor alphaImmune responseNatural clearance
2002
Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)
Downer M, Hodge T, Smith D, Qari S, Schuman P, Mayer K, Klein R, Vlahov D, Gardner L, McNicholl J. Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS). Genes & Immunity 2002, 3: 295-298. PMID: 12140749, DOI: 10.1038/sj.gene.6363884.Peer-Reviewed Original ResearchConceptsHIV Epidemiology Research StudyRace/ethnicityHIV-1HIV Epidemiologic Research StudyAfrican AmericansCCR5-Δ32 genotypeHIV-1 transmissionEpidemiologic research studiesHost genetic factorsHispanic/LatinaBlack/African AmericanUninfected womenAA womenUS womenCCR5-Δ32US populationWhite womenFrequency of heterozygotesWomenGenetic factorsDistributions of heterozygotesRegional variationResearch studies
2001
Effect of a Single Amino Acid Change in MHC Class I Molecules on the Rate of Progression to AIDS
Gao X, Nelson G, Karacki P, Martin M, Phair J, Kaslow R, Goedert J, Buchbinder S, Hoots K, Vlahov D, O'Brien S, Carrington M. Effect of a Single Amino Acid Change in MHC Class I Molecules on the Rate of Progression to AIDS. New England Journal Of Medicine 2001, 344: 1668-1675. PMID: 11386265, DOI: 10.1056/nejm200105313442203.Peer-Reviewed Original ResearchConceptsRate of progressionHIV-1 infectionClass IHuman immunodeficiency virus type 1 (HIV-1) infectionDifferent peptide-binding specificitiesVirus type 1 infectionRisk of progressionT lymphocyte responsesInfluence of HLAType 1 infectionHIV-1 epitopesSubtypes of HLAHLA class IPeptide-binding specificityMHC class I moleculesAmino acid changesComplex class ISingle amino acid changeClass I moleculesReactive HLAImmunodeficiency syndromeRelated HLAPx groupCommon HLAHIV-1Racial Differences in HLA Class II Associations with Hepatitis C Virus Outcomes
Thio C, Thomas D, Goedert J, Vlahov D, Nelson K, Hilgartner M, O’Brien S, Karacki P, Marti D, Astemborski J, Carrington M. Racial Differences in HLA Class II Associations with Hepatitis C Virus Outcomes. The Journal Of Infectious Diseases 2001, 184: 16-21. PMID: 11398104, DOI: 10.1086/321005.Peer-Reviewed Original ResearchConceptsHuman leukocyte antigenClass II associationsViral clearanceClass II HLA typingClass II human leukocyte antigenHepatitis C virus clearanceHLA class II associationsCD4 T cell responsesT cell responsesClass II allelesHepatitis C virus outcomeHCV clearanceLeukocyte antigenVirus clearanceViral persistenceHLA typingImmune responseHomogeneous cohortCell responsesWhite subjectsDiverse cohortCohortClearanceVaried cohortsBlack subjects
2000
Influence of CCR5 promoter haplotypes on AIDS progression in African–Americans
An P, Martin M, Nelson G, Carrington M, Smith M, Gong K, Vlahov D, O'Brien S, Winkler C. Influence of CCR5 promoter haplotypes on AIDS progression in African–Americans. AIDS 2000, 14: 2117-2122. PMID: 11061652, DOI: 10.1097/00002030-200009290-00007.Peer-Reviewed Original ResearchConceptsCCR5 promoter haplotypesAIDS progressionSurvival analysisAfrican AmericansNatural history cohort studyPromoter haplotypesRate of progressionPromoter variantsCohort studyCCR5 alleleRapid progressionCaucasian cohortProgressionCaucasiansComplete linkage disequilibriumCCR2AIDSUnidentified polymorphismsRacial groupsLinkage disequilibriumSeroconvertersCCR5CohortHaplotypes
1999
Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-delta32 mutation.
Dean M, Jacobson L, McFarlane G, Margolick J, Jenkins F, Howard O, Dong H, Goedert J, Buchbinder S, Gomperts E, Vlahov D, Oppenheim J, O'Brien S, Carrington M. Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-delta32 mutation. Cancer Research 1999, 59: 3561-4. PMID: 10446961.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsB-LymphocytesCase-Control StudiesChemokine CCL5Cohort StudiesGene FrequencyGenetic Predisposition to DiseaseHIV-1HumansLymphoma, AIDS-RelatedMalePoint MutationReceptors, CCR5RiskSarcoma, KaposiSequence DeletionTetradecanoylphorbol AcetateWhite PeopleConceptsNon-Hodgkin lymphomaB cellsAIDS lymphomasCCR5 geneRisk of NHLMulticenter AIDS Cohort StudyCCR5 ligand RANTEST-cell declineAIDS Cohort StudyCCR5-Delta32 alleleB-cell lymphomaCase-control analysisCCR5-Delta32 mutationChemokine receptor genesCCR5 chemokine receptor geneTime of infectionLigand RANTESTime AIDSCohort studyOpportunistic infectionsAIDS patientsCommon malignancyKaposi's sarcomaNHL casesProliferative response
1997
Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression
Smith M, Dean M, Carrington M, Winkler C, Huttley G, Lomb D, Goedert J, O'Brien T, Jacobson L, Kaslow R, Buchbinder S, Vittinghoff E, Vlahov D, Hoots K, Hilgartner M, Study H, San Francisco City Cohort ALIVE Study M, O'Brien S. Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression. Science 1997, 277: 959-965. PMID: 9252328, DOI: 10.1126/science.277.5328.959.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBlack PeopleCohort StudiesDisease ProgressionGenotypeHaplotypesHeterozygoteHIV InfectionsHIV-1HumansMutationPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPolymorphism, Single-Stranded ConformationalProportional Hazards ModelsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CytokineReceptors, HIVSurvival AnalysisWhite PeopleConceptsHIV-1 infectionCCR2-64IDisease progressionHIV-1 disease progressionHIV-1-infected individualsLong-term survivorsCCR2-64I alleleReceptor geneChemokine receptor genesAIDS 2CCR2 chemokineSyndrome cohortAIDS patientsCCR5-Delta32Human immunodeficiencyChemokine receptorsCCR5 variantsCCR2CCR5InfectionIndependent effectsAfrican AmericansMutant genotypesProgressionGenetic association analysis
1991
Risk factors for shooting gallery use and cessation among intravenous drug users.
Celentano D, Vlahov D, Cohn S, Anthony J, Solomon L, Nelson K. Risk factors for shooting gallery use and cessation among intravenous drug users. American Journal Of Public Health 1991, 81: 1291-5. PMID: 1928528, PMCID: PMC1405311, DOI: 10.2105/ajph.81.10.1291.Peer-Reviewed Original ResearchConceptsIntravenous drug usersActive intravenous drug usersGallery useRisk factorsDrug usersShooting galleriesHIV-1 transmissionHIV-1 serostatusHIV-1 infectionLow socioeconomic statusLifetime attendanceHomosexuality/bisexualityBlack raceMale genderDrug useMultivariate analysisReporting useGallery attendanceSocioeconomic statusDrug involvementCessationHigh-risk environmentsAttendanceSerostatusInfection