2013
Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population
Manini A, Jacobs M, Vlahov D, Hurd Y. Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population. Journal Of Medical Toxicology 2013, 9: 148-154. PMID: 23318993, PMCID: PMC3648633, DOI: 10.1007/s13181-012-0286-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlternative SplicingAmino Acid SubstitutionBenzodiazepinesCohort StudiesDrug OverdoseFemaleFollow-Up StudiesGenetic Association StudiesGenetic Predisposition to DiseaseHeart ArrestHumansMaleNarcoticsPilot ProjectsPolymorphism, Single NucleotideProspective StudiesReceptors, Opioid, muRespiratory InsufficiencySeverity of Illness IndexSympathomimeticsUnited StatesConceptsAcute drug overdoseG variant alleleClinical severityVariant allelesEmergency departmentDrug overdoseSingle nucleotide polymorphismsConsecutive adult ED patientsHuman mu-opioid receptor geneReceptor single nucleotide polymorphismsWorse clinical severityAdult ED patientsObservational cohort studyUrban teaching hospitalMu-opioid receptor geneAbove single nucleotide polymorphismsCohort studyED patientsRespiratory arrestCardiac arrestClinical variablesAcute drugSevere outcomesTeaching hospitalBlood samples
1999
Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-delta32 mutation.
Dean M, Jacobson L, McFarlane G, Margolick J, Jenkins F, Howard O, Dong H, Goedert J, Buchbinder S, Gomperts E, Vlahov D, Oppenheim J, O'Brien S, Carrington M. Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-delta32 mutation. Cancer Research 1999, 59: 3561-4. PMID: 10446961.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsB-LymphocytesCase-Control StudiesChemokine CCL5Cohort StudiesGene FrequencyGenetic Predisposition to DiseaseHIV-1HumansLymphoma, AIDS-RelatedMalePoint MutationReceptors, CCR5RiskSarcoma, KaposiSequence DeletionTetradecanoylphorbol AcetateWhite PeopleConceptsNon-Hodgkin lymphomaB cellsAIDS lymphomasCCR5 geneRisk of NHLMulticenter AIDS Cohort StudyCCR5 ligand RANTEST-cell declineAIDS Cohort StudyCCR5-Delta32 alleleB-cell lymphomaCase-control analysisCCR5-Delta32 mutationChemokine receptor genesCCR5 chemokine receptor geneTime of infectionLigand RANTESTime AIDSCohort studyOpportunistic infectionsAIDS patientsCommon malignancyKaposi's sarcomaNHL casesProliferative responseDiffering Risk Factors for Cerebral Palsy in the Presence of Mental Retardation and Epilepsy
Arpino C, Curatolo P, Stazi M, Pellegri A, Vlahov D. Differing Risk Factors for Cerebral Palsy in the Presence of Mental Retardation and Epilepsy. Journal Of Child Neurology 1999, 14: 151-155. PMID: 10190264, DOI: 10.1177/088307389901400303.Peer-Reviewed Original ResearchConceptsCerebral palsyDiagnosis groupsMental retardationDual diagnosis groupHistory of epilepsyFirst-degree relativesGestational ageSevere manifestationsRisk factorsEtiopathogenetic pathwaysPalsyMother's ageNeonatal convulsionsMaternal educationEpilepsyOverlapping outcomesAgeRetardationChildrenGroupBirthweightConvulsionsYearsDiagnosisWeeks
1998
Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5
Martin M, Dean M, Smith M, Winkler C, Gerrard B, Michael N, Lee B, Doms R, Margolick J, Buchbinder S, Goedert J, O'Brien T, Hilgartner M, Vlahov D, O'Brien S, Carrington M. Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5. Science 1998, 282: 1907-1911. PMID: 9836644, DOI: 10.1126/science.282.5395.1907.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAllelesChemokine CXCL12Chemokines, CXCCohort StudiesDisease ProgressionGenes, DominantGenes, RecessiveGenetic Predisposition to DiseaseGenotypeHaplotypesHeterozygoteHIV InfectionsHIV-1HomozygoteHumansPromoter Regions, GeneticProportional Hazards ModelsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CytokineRisk FactorsSurvival RateConceptsAIDS progressionCell-surface chemokine receptor moleculeCCR5 regulatory regionsChemokine receptor moleculesPercent of patientsAIDS disease progressionHIV-1 infectionCohort of peopleMacrophage-tropic strainsAIDS restriction genesDistinct regulatory influencesCCR2-64IPrincipal coreceptorImmunodeficiency syndromeCCR5-Delta32Genetic epidemiologic analysisDisease progressionHuman immunodeficiencySDF1-3'APromoter genotypeCCR5 geneInfected individualsEpidemiologic analysisHost factorsProgression