2001
Effect of a Single Amino Acid Change in MHC Class I Molecules on the Rate of Progression to AIDS
Gao X, Nelson G, Karacki P, Martin M, Phair J, Kaslow R, Goedert J, Buchbinder S, Hoots K, Vlahov D, O'Brien S, Carrington M. Effect of a Single Amino Acid Change in MHC Class I Molecules on the Rate of Progression to AIDS. New England Journal Of Medicine 2001, 344: 1668-1675. PMID: 11386265, DOI: 10.1056/nejm200105313442203.Peer-Reviewed Original ResearchConceptsRate of progressionHIV-1 infectionClass IHuman immunodeficiency virus type 1 (HIV-1) infectionDifferent peptide-binding specificitiesVirus type 1 infectionRisk of progressionT lymphocyte responsesInfluence of HLAType 1 infectionHIV-1 epitopesSubtypes of HLAHLA class IPeptide-binding specificityMHC class I moleculesAmino acid changesComplex class ISingle amino acid changeClass I moleculesReactive HLAImmunodeficiency syndromeRelated HLAPx groupCommon HLAHIV-1
1999
Class II HLA Alleles and Hepatitis B Virus Persistence in African Americans
Thio C, Carrington M, Marti D, O'Brien S, Vlahov D, Nelson K, Astemborski J, Thomas D. Class II HLA Alleles and Hepatitis B Virus Persistence in African Americans. The Journal Of Infectious Diseases 1999, 179: 1004-1006. PMID: 10068598, DOI: 10.1086/314684.Peer-Reviewed Original ResearchConceptsHBV persistenceHBV infectionImmune responseClass II HLA typingHepatitis B virus (HBV) persistenceHepatitis B virus infectionClass II HLA allelesB virus infectionPersistent HBV infectionClass I associationsHost immune responseClass II allelesAfrican American cohortAntigen presentationVirus infectionHLA typingHLA allelesVirus persistenceTwo-locus haplotypesAmerican cohortThree-locus haplotypesClass IIHLA complexInfectionClass I