2024
An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchConceptsYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive disorderCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual-patient data meta-analysisPosttreatment scoresEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusIndividual participant data meta-analysisSystematic reviewDisordersData meta-analysisPosttreatmentRemission definitionsImpressive improvement
2017
NEUROIMAGING OF SUBCORTICAL BRAIN VOLUME ALTERATIONS IN PEADIATRIC AND ADULT OBSESSIVE-COMPULSIVE DISORDER: Preliminary findings from the ENIGMA Obsessive-Compulsive Disorder working group
Boedhoe P, Schmaal L, Reddy J, Kwon J, Cheng Y, Nakamae T, Spalletta G, Beucke J, Soriano-Mas C, Lazaro L, Fitzgerald K, Koch K, Hoexter M, Benedetti F, Nakao T, Wang Z, Mataix-Cols D, Simpson H, Walitza S, Tolin D, Arnold P, Huyser C, Denys D, Soreni N, Guner P, Group* E, Thompson P, Hibar D, Jahanshad N, Stein D, van den Heuvel O. NEUROIMAGING OF SUBCORTICAL BRAIN VOLUME ALTERATIONS IN PEADIATRIC AND ADULT OBSESSIVE-COMPULSIVE DISORDER: Preliminary findings from the ENIGMA Obsessive-Compulsive Disorder working group. European Neuropsychopharmacology 2017, 27: 617-619. DOI: 10.1016/j.euroneuro.2016.07.024.Peer-Reviewed Original ResearchBrain volume alterationsPediatric OCD patientsIndividual participant dataThalamus volumeIntracranial volumeOCD patientsDisease durationHippocampal abnormalitiesLateral ventricleSymptom severityVolume alterationsRandom-effects meta-analysis modelRobust imaging markerSeparate stratified analysesLonger disease durationAdult obsessive-compulsive disorderSmaller hippocampal volumesPathophysiology of OCDTotal intracranial volumeAdult OCD patientsMeta-regression analysisMeta-analysis modelPediatric OCD casesSubcortical brain volumesLimited statistical power