2024
RESOLVING THE CHALLENGES OF BIG-DATA IMAGING GENETICS ANALYSIS TO UNDERSTAND GENETIC AND ENVIRONMENTAL RISK FACTORS IN PSYCHIATRIC DISORDERS
Kochunov P, Nichols T, Blangero J, Medland S, Glahn D, Hong E. RESOLVING THE CHALLENGES OF BIG-DATA IMAGING GENETICS ANALYSIS TO UNDERSTAND GENETIC AND ENVIRONMENTAL RISK FACTORS IN PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2024, 87: 21-22. DOI: 10.1016/j.euroneuro.2024.08.056.Peer-Reviewed Original ResearchGenetic analysisGenome-wide associationBrain patternsImaging genetic analysisImaging genetic datasetGenetic resolutionGenetic risk factorsGenetic datasetsGenetic dataDepressive disorderPsychiatric disordersRisk of development of dementiaVariance componentsHigh-resolution neuroimagingDevelopment of dementiaNurturing interactionsEnvironmental risk factorsAlzheimer's diseaseGenetic correlationsRisk factorsTreatment effectsDisordersLongitudinal datasetPsychosisSNPsNeurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
Jiang Y, Luo C, Wang J, Palaniyappan L, Chang X, Xiang S, Zhang J, Duan M, Huang H, Gaser C, Nemoto K, Miura K, Hashimoto R, Westlye L, Richard G, Fernandez-Cabello S, Parker N, Andreassen O, Kircher T, Nenadić I, Stein F, Thomas-Odenthal F, Teutenberg L, Usemann P, Dannlowski U, Hahn T, Grotegerd D, Meinert S, Lencer R, Tang Y, Zhang T, Li C, Yue W, Zhang Y, Yu X, Zhou E, Lin C, Tsai S, Rodrigue A, Glahn D, Pearlson G, Blangero J, Karuk A, Pomarol-Clotet E, Salvador R, Fuentes-Claramonte P, Garcia-León M, Spalletta G, Piras F, Vecchio D, Banaj N, Cheng J, Liu Z, Yang J, Gonul A, Uslu O, Burhanoglu B, Uyar Demir A, Rootes-Murdy K, Calhoun V, Sim K, Green M, Quidé Y, Chung Y, Kim W, Sponheim S, Demro C, Ramsay I, Iasevoli F, de Bartolomeis A, Barone A, Ciccarelli M, Brunetti A, Cocozza S, Pontillo G, Tranfa M, Park M, Kirschner M, Georgiadis F, Kaiser S, Van Rheenen T, Rossell S, Hughes M, Woods W, Carruthers S, Sumner P, Ringin E, Spaniel F, Skoch A, Tomecek D, Homan P, Homan S, Omlor W, Cecere G, Nguyen D, Preda A, Thomopoulos S, Jahanshad N, Cui L, Yao D, Thompson P, Turner J, van Erp T, Cheng W, Feng J. Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm. Nature Communications 2024, 15: 5996. PMID: 39013848, PMCID: PMC11252381, DOI: 10.1038/s41467-024-50267-3.Peer-Reviewed Original ResearchConceptsGray matter changesDisorder constructsEnlarged striatumPsychiatric conditionsMental disordersSubcortical regionsSchizophreniaBiological foundationsMatter changesBrain imagingStriatumDisordersBiological factorsIndividualsSubtypesHealthy subjectsCross-sectional brain imagingHippocampusTemporal trajectoriesInternational cohortSubgroup 2Subgroup 1Subgroups8. The Relationship Between Treatment, Symptom Severity, and Brain Connectivity in Bipolar Disorder: An International Study Across 16 Enigma-Bipolar Sites
Nabulsi L, Kang M, Jahanshad N, Haarman B, McDonald C, Stein D, Glahn D, Pomarol-Clotet E, Vieta E, Houenou J, Favre P, Polosan M, Brambilla P, Bellani M, Mitchell P, Dannlowski U, Wessa M, Phillips M, Kircher T, Thompson P, Andreassen O, Ching C, Cannon D, Group E. 8. The Relationship Between Treatment, Symptom Severity, and Brain Connectivity in Bipolar Disorder: An International Study Across 16 Enigma-Bipolar Sites. Biological Psychiatry 2024, 95: s76-s77. DOI: 10.1016/j.biopsych.2024.02.186.Peer-Reviewed Original Research
2016
Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses: Insights from Neuroimaging and Computational Neuroscience
Krystal J, Anticevic A, Murray J, Glahn D, Driesen N, Yang G, Wang X. Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses: Insights from Neuroimaging and Computational Neuroscience. 2016, 293-316. DOI: 10.7551/mitpress/10936.003.0023.Peer-Reviewed Original ResearchPsychiatric disordersMechanisms of psychiatric disordersModel psychiatric disordersPsychiatric nosologyPsychological assessmentPsychiatric diagnosingModern psychiatryPsychiatric issuesNeurobiologyPsychiatristsNeurological analysisPsychiatryDisordersComputational neuroscienceClinical heterogeneityNeuroimagingNosologyNeuroscienceNeuroscientistsComputational neuroscientistsCategorization