RESOLVING THE CHALLENGES OF BIG-DATA IMAGING GENETICS ANALYSIS TO UNDERSTAND GENETIC AND ENVIRONMENTAL RISK FACTORS IN PSYCHIATRIC DISORDERS
Kochunov P, Nichols T, Blangero J, Medland S, Glahn D, Hong E. RESOLVING THE CHALLENGES OF BIG-DATA IMAGING GENETICS ANALYSIS TO UNDERSTAND GENETIC AND ENVIRONMENTAL RISK FACTORS IN PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2024, 87: 21-22. DOI: 10.1016/j.euroneuro.2024.08.056.Peer-Reviewed Original ResearchGenetic analysisGenome-wide associationBrain patternsImaging genetic analysisImaging genetic datasetGenetic resolutionGenetic risk factorsGenetic datasetsGenetic dataDepressive disorderPsychiatric disordersRisk of development of dementiaVariance componentsHigh-resolution neuroimagingDevelopment of dementiaNurturing interactionsEnvironmental risk factorsAlzheimer's diseaseGenetic correlationsRisk factorsTreatment effectsDisordersLongitudinal datasetPsychosisSNPsRole of Neurocellular Endoplasmic Reticulum Stress Response in Alzheimer’s Disease and Related Dementias Risk
Aceves M, Granados J, Leandro A, Peralta J, Glahn D, Williams-Blangero S, Curran J, Blangero J, Kumar S. Role of Neurocellular Endoplasmic Reticulum Stress Response in Alzheimer’s Disease and Related Dementias Risk. Genes 2024, 15: 569. PMID: 38790197, PMCID: PMC11121587, DOI: 10.3390/genes15050569.Peer-Reviewed Original ResearchTranscriptional response to ER stressProtein kinase RNA-like ER kinaseActivating transcription factor 6Inositol-requiring enzyme-1ER stress responseUnfolded protein responseElevated endoplasmic reticulumAlzheimer's diseaseResponse to ER stressSarco/endoplasmic reticulum Ca2+-ATPaseNeural stem cellsRNA-like ER kinaseStress responseAnalysis of DE genesG1/S phase cell cycle arrestEndoplasmic reticulum stress responseInduced G1/S-phase cell cycle arrestPostmortem AD brainsGene network analysisTranscription factor 6E2F transcription factor 1Animal models of ADCell cycle arrestModel of ADBinding protein 1