2023
Perspectives on contingency management for alcohol use and alcohol‐associated conditions among people in care with HIV
Cohen S, DePhilippis D, Deng Y, Dziura J, Ferguson T, Fucito L, Justice A, Maisto S, Marconi V, Molina P, Paris M, Rodriguez‐Barradas M, Simberkoff M, Petry N, Fiellin D, Edelman E. Perspectives on contingency management for alcohol use and alcohol‐associated conditions among people in care with HIV. Alcohol Clinical And Experimental Research 2023, 47: 1783-1797. PMID: 37524371, PMCID: PMC10828101, DOI: 10.1111/acer.15159.Peer-Reviewed Original ResearchUnhealthy alcohol useAlcohol useContingency managementPrimary care settingSubset of participantsReward structureEvidence-based approachHIV clinicImplementation science frameworkTreatment trialsClinical trialsIntervention feasibilityCare settingsPromoting ActionAlcohol consumptionRelated conditionsBiochemical testingClinical contextHIVReward schedulePatientsReward processesInterventionTrialsBehavior changeURINE TOXICOLOGY PROFILES OF EMERGENCY DEPARTMENT PATIENTS WITH UNTREATED OPIOID USE DISORDER: A MULTI-SITE VIEW
Cowan E, Perrone J, Dziura J, Edelman E, Hawk K, Herring A, McCormack R, Murphy A, Phadke M, Fiellin D, D'Onofrio G. URINE TOXICOLOGY PROFILES OF EMERGENCY DEPARTMENT PATIENTS WITH UNTREATED OPIOID USE DISORDER: A MULTI-SITE VIEW. Journal Of Emergency Medicine 2023, 65: e357-e365. PMID: 37716904, PMCID: PMC10591927, DOI: 10.1016/j.jemermed.2023.06.007.Peer-Reviewed Original ResearchUrine drug screensOpioid use disorderEmergency departmentUntreated opioid use disorderAdult ED patientsOpioid overdose deathsED patientsOnly opioidCommon opioidsOverdose deathsUse disordersCommon drugsOpioidsPolysubstance useDrug useDrug screensAmphetamine-type stimulantsFentanylPatientsAddiction treatmentStimulantsParticipantsBuprenorphineMethadoneBenzodiazepines
2021
SOAPs and SUDs: Patients With Substance Use Disorders and What Clinicians Should Know About the Cures Act
Chan CA, Tetrault JM, Fiellin DA, Weimer MB. SOAPs and SUDs: Patients With Substance Use Disorders and What Clinicians Should Know About the Cures Act. Journal Of Addiction Medicine 2021, 16: 141-142. PMID: 34049315, DOI: 10.1097/adm.0000000000000879.Commentaries, Editorials and Letters
2019
Vaping—Seeking Clarity in a Time of Uncertainty
Baldassarri SR, Fiellin DA, Friedman AS. Vaping—Seeking Clarity in a Time of Uncertainty. JAMA 2019, 322: 1951-1952. PMID: 31697311, PMCID: PMC8284981, DOI: 10.1001/jama.2019.16493.Commentaries, Editorials and Letters
2016
Primary Care Physicians’ Willingness to Prescribe HIV Pre-exposure Prophylaxis for People who Inject Drugs
Edelman EJ, Moore BA, Calabrese SK, Berkenblit G, Cunningham C, Patel V, Phillips K, Tetrault JM, Shah M, Fiellin DA, Blackstock O. Primary Care Physicians’ Willingness to Prescribe HIV Pre-exposure Prophylaxis for People who Inject Drugs. AIDS And Behavior 2016, 21: 1025-1033. PMID: 27896552, PMCID: PMC5344709, DOI: 10.1007/s10461-016-1612-6.Peer-Reviewed Original ResearchConceptsPrimary care physiciansPre-exposure prophylaxisCare physiciansHIV pre-exposure prophylaxisHIV risk groupMore HIVClinic patientsRisk groupsGeneral internistsPWIDAcademic general internistsPractice characteristicsDisease preventionHIVPrEPProphylaxisPatientsPhysiciansCareDrugsOnline surveyInternistsHigher willingnessLower willingnessCentral roleThe impact of prescribed opioids on CD4 cell count recovery among HIV‐infected patients newly initiating antiretroviral therapy
Edelman E, Gordon K, Tate J, Becker W, Bryant K, Crothers K, Gaither, Gibert C, Gordon A, Marshall B, Rodriguez‐Barradas M, Samet J, Skanderson M, Justice A, Fiellin D. The impact of prescribed opioids on CD4 cell count recovery among HIV‐infected patients newly initiating antiretroviral therapy. HIV Medicine 2016, 17: 728-739. PMID: 27186715, PMCID: PMC5053822, DOI: 10.1111/hiv.12377.Peer-Reviewed Original ResearchConceptsCD4 cell countBaseline CD4 cell countCell countPrescribed opioidsImmunosuppressive propertiesVeterans Aging Cohort Study (VACS) dataCD4 cell count recoveryAntiretroviral therapy responseCell count recoveryShort-term opioidsViral load suppressionCohort study dataOverall disease severityYear of initiationPrimary independent variableOpioid durationAntiretroviral therapyCount recoveryComorbid conditionsPharmacy dataOpioid propertiesTherapy responseOpioidsPatientsHIV
2015
Dose and other factors associated with decreased pain intensity among patients initiating buprenorphine/naloxone
Becker W, Ganoczy D, Fiellin D, Bohnert A. Dose and other factors associated with decreased pain intensity among patients initiating buprenorphine/naloxone. Drug And Alcohol Dependence 2015, 146: e221. DOI: 10.1016/j.drugalcdep.2014.09.068.Peer-Reviewed Original Research
2014
Substance use in older HIV-infected patients
Edelman EJ, Tetrault JM, Fiellin DA. Substance use in older HIV-infected patients. Current Opinion In HIV And AIDS 2014, 9: 317-324. PMID: 24824888, PMCID: PMC4175926, DOI: 10.1097/coh.0000000000000069.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersSubstance useTreatment optionsHealth consequencesPotential treatment optionStimulant use disorderRelated health consequencesOlder HIVAntiretroviral therapyHIVPatientsBrief counselingHealth outcomesEffective interventionsComplex needsMedicationsDisordersCounseling strategiesInterventionOutcomesTobaccoLife courseOptionsTherapy
2013
Treating Pain in Patients Receiving Methadone Maintenance for Opioid Dependence
Alford D, Barry D, Fiellin D. Treating Pain in Patients Receiving Methadone Maintenance for Opioid Dependence. 2013, 31-37. DOI: 10.1007/978-1-4614-6974-2_3.ChaptersPain complaintsOpioid dependenceMethadone maintenanceChronic painOpioid-dependent patientsIllicit opioid useTreatment of painOpioid usePrescription opioidsMaintenance treatmentPain perceptionClinical challengePainPsychiatric disordersPatientsMethadonePhysiologic toleranceEffective coping skillsComplaintsOpioidsMedicationsTreatmentCoping skillsLoss of controlAddiction
2012
Prevalence of Unhealthy Substance Use on Teaching and Hospitalist Medical Services: Implications for Education
Holt SR, Ramos J, Harma MA, Cabrera F, Louis‐Ashby C, Dinh A, Tetrault JM, Fiellin DA. Prevalence of Unhealthy Substance Use on Teaching and Hospitalist Medical Services: Implications for Education. American Journal On Addictions 2012, 21: 111-119. PMID: 22332853, DOI: 10.1111/j.1521-0391.2011.00207.x.Peer-Reviewed Original ResearchConceptsUnhealthy substance useAlcohol Use Disorders Identification Test-ConsumptionInternal medicine admissionsSubstance useHours of admissionTeaching serviceCommunity teaching hospitalCross-sectional studyDrug Abuse Screening TestMedical teaching serviceAbuse Screening TestMedicine admissionsChart reviewCurrent smokersMedical inpatientsPatient admissionsTeaching hospitalHospitalist serviceCase findingPatientsAdmissionDiagnostic InterviewScreening testMedical resident trainingT patients
2011
Hepatic Safety and Antiretroviral Effectiveness in HIV‐Infected Patients Receiving Naltrexone
Tetrault JM, Tate JP, McGinnis KA, Goulet JL, Sullivan LE, Bryant K, Justice AC, Fiellin DA, Team F. Hepatic Safety and Antiretroviral Effectiveness in HIV‐Infected Patients Receiving Naltrexone. Alcohol Clinical And Experimental Research 2011, 36: 318-324. PMID: 21797892, PMCID: PMC3221963, DOI: 10.1111/j.1530-0277.2011.01601.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlanine TransaminaseAlcoholismAntiretroviral Therapy, Highly ActiveAspartate AminotransferasesCD4 Lymphocyte CountChemical and Drug Induced Liver InjuryCohort StudiesDatabases, FactualDrug InteractionsDrug-Related Side Effects and Adverse ReactionsFemaleHIV InfectionsHumansLiverLiver Function TestsMaleMiddle AgedNaltrexoneNarcotic AntagonistsOpioid-Related DisordersRNA, ViralVeteransConceptsNaltrexone prescriptionAlanine aminotransferaseOpioid dependenceVeterans Aging Cohort Study Virtual CohortAspartate aminotransferaseImpact of naltrexoneSignificant alanine aminotransferaseLiver enzyme elevationMean CD4 countHIV-infected individualsAST changesHepatic safetyHIV biomarkersOral naltrexoneCD4 countHIV RNAMedian durationEnzyme elevationMedian ageAST levelsNaltrexone useHepatic enzymesAntiretroviral effectivenessHIVPatientsA Meta‐analysis of the Efficacy of Nonphysician Brief Interventions for Unhealthy Alcohol Use: Implications for the Patient‐Centered Medical Home
Sullivan LE, Tetrault JM, Braithwaite RS, Turner BJ, Fiellin DA. A Meta‐analysis of the Efficacy of Nonphysician Brief Interventions for Unhealthy Alcohol Use: Implications for the Patient‐Centered Medical Home. American Journal On Addictions 2011, 20: 343-356. PMID: 21679266, DOI: 10.1111/j.1521-0391.2011.00143.x.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useBrief interventionAlcohol usePrimary careStandard drinksBrief physician interventionPrimary care patientsEnglish-language literatureCare patientsHeterogeneity of resultsPhysician interventionNonphysician cliniciansMedical homeAlcohol consumptionSystematic reviewMeta-AnalysisPatientsStatistical significanceDrinking outcomesNonphysiciansInterventionAlcohol problemsDrug Treatment Outcomes Among HIV-Infected Opioid-Dependent Patients Receiving Buprenorphine/Naloxone
Fiellin DA, Weiss L, Botsko M, Egan JE, Altice FL, Bazerman LB, Chaudhry A, Cunningham CO, Gourevitch MN, Lum PJ, Sullivan LE, Schottenfeld RS, O'Connor PG. Drug Treatment Outcomes Among HIV-Infected Opioid-Dependent Patients Receiving Buprenorphine/Naloxone. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2011, 56: s33-s38. PMID: 21317592, PMCID: PMC3863630, DOI: 10.1097/qai.0b013e3182097537.Peer-Reviewed Original ResearchConceptsBuprenorphine/naloxoneBuprenorphine/naloxone treatmentOpioid-dependent patientsDrug useOpioid useNaloxone treatmentHIV treatment settingsIllicit opioid useOngoing drug useDrug treatment outcomesNaloxone dosesIllicit opioidsOpioid dependenceOffice visitsProspective studyHIV treatmentRetained patientsTreatment outcomesTreatment retentionPatientsTreatment settingsAddiction treatment processNaloxoneTreatment populationHIV
2010
Substance Use in Patients with Sexually Transmitted Infections: Results from a National U.S. Survey
Tetrault JM, Fiellin DA, Niccolai LM, Sullivan LE. Substance Use in Patients with Sexually Transmitted Infections: Results from a National U.S. Survey. American Journal On Addictions 2010, 19: 504-509. PMID: 20958845, DOI: 10.1111/j.1521-0391.2010.00087.x.Peer-Reviewed Original ResearchConceptsAlcohol abuse/dependenceAbuse/dependenceSubstance usePast-year alcohol useMarijuana usePast-month bingeTransmitted InfectionsPrescription opioidsGeneral populationCocaine useNonmedical useAlcohol useHeavy drinkingSTIsNational U.S. SurveyPatientsInfectionOpioidsCliniciansPrevalenceBingeDiagnosisU.S. survey
2008
Narrative review: buprenorphine for opioid-dependent patients in office practice.
Sullivan LE, Fiellin DA. Narrative review: buprenorphine for opioid-dependent patients in office practice. Annals Of Internal Medicine 2008, 148: 662-70. PMID: 18458279, PMCID: PMC3694223, DOI: 10.7326/0003-4819-148-9-200805060-00006.Peer-Reviewed Original ResearchConceptsOpioid dependencePrescription opioidsPartial opioid agonistOpioid-dependent patientsOpioid-dependent personsUse of buprenorphineOffice-based treatmentBuprenorphine-naloxone combinationClinical presentationIllicit opioidsOpioid agonistsPatient populationOpioidsBuprenorphineOffice practicePatientsTreatmentRecent dataPhysiciansAbuseAgonistsPrevalenceHeroin
2006
Counseling plus Buprenorphine–Naloxone Maintenance Therapy for Opioid Dependence
Fiellin DA, Pantalon MV, Chawarski MC, Moore BA, Sullivan LE, O'Connor PG, Schottenfeld RS. Counseling plus Buprenorphine–Naloxone Maintenance Therapy for Opioid Dependence. New England Journal Of Medicine 2006, 355: 365-374. PMID: 16870915, DOI: 10.1056/nejmoa055255.Peer-Reviewed Original ResearchConceptsStandard medical managementBuprenorphine-naloxone treatmentIllicit opioid useMedical managementOpioid dependenceWeekly medicationOpioid useIllicit opioidsWeekly counselingPrimary careUrine specimensConsecutive weeksProportion of patientsImproved treatment outcomesMaintenance therapyPrimary outcomeClinical trialsMedication distributionSimilar efficacyTreatment outcomesMedicationsSelf-reported frequencyPatientsFrequency of attendanceMean percentage
2005
Faculty Development in Small-Group Teaching Skills Associated with a Training Course on Office-Based Treatment of Opioid Dependence
Wong JG, Holmboe ES, Becker W, Fiellin D, Jara G, Martin J. Faculty Development in Small-Group Teaching Skills Associated with a Training Course on Office-Based Treatment of Opioid Dependence. Substance Use & Addiction Journal 2005, 25: 35-40. PMID: 16172091, DOI: 10.1300/j465v25n04_05.Peer-Reviewed Original ResearchConceptsOpioid dependenceDrug Addiction Treatment ActOffice-Based TreatmentOpioid-dependent patientsOpioid treatment programsTreatment programQualified physiciansScore responsesSchedule IIITreatment ActDATADescriptive questionnairePhysiciansTraining sessionsTreatmentPatient case discussionsSignificant improvementFacilitatorsSessionsMedicationsBuprenorphinePatients
2004
Counseling Requirements for Buprenorphine Maintenance in Primary Care
Pantalon M, Fiellin D, O’Connor P, Chawarski M, Pakes J, Schottenfeld R. Counseling Requirements for Buprenorphine Maintenance in Primary Care. Addictive Disorders & Their Treatment 2004, 3: 71-76. DOI: 10.1097/00132576-200406000-00003.Peer-Reviewed Original ResearchUrine toxicology testsMedical managementPrimary care settingBuprenorphine maintenanceCare settingsDrug counselingCounseling requirementsToxicology testsBuprenorphine-maintained patientsOpioid-dependent patientsMethadone maintenance programIndividual drug counselingBuprenorphine treatmentOpioid dependenceDependent patientsPrimary carePatientsConsecutive weeksDrug counselorsStatistical significanceWeeksPreliminary feasibilityPreliminary findingsEfficacyCounseling
2002
New federal initiatives to enhance the medical treatment of opioid dependence.
Fiellin DA, O'Connor PG. New federal initiatives to enhance the medical treatment of opioid dependence. Annals Of Internal Medicine 2002, 137: 688-92. PMID: 12379070, DOI: 10.7326/0003-4819-137-8-200210150-00014.Peer-Reviewed Original ResearchConceptsOpioid dependenceMedical treatmentOpioid agonist medicationsRole of internistsAgonist medicationsPharmacologic treatmentMaintenance treatmentNew medicationsMedical conditionsOffice settingSubstantial healthMedicationsPatientsTreatmentInternistsRecent federal initiativesFederal initiativesNew federal initiativesComplicationsCareRisk for Delirium Tremens in Patients with Alcohol Withdrawal Syndrome
Fiellin D, O'Connor P, Holmboe E, Horwitz R. Risk for Delirium Tremens in Patients with Alcohol Withdrawal Syndrome. Substance Use & Addiction Journal 2002, 23: 83-94. DOI: 10.1023/a:1015350005418.Peer-Reviewed Original ResearchAdverse clinical featuresDelirium tremensComplicated withdrawalBlood pressureClinical featuresComplicated alcohol withdrawalElevated blood pressureAlcohol withdrawal syndromeSystolic blood pressureCase-control studyDSM-IV criteriaComorbidity scoreMedical comorbiditiesAlcohol withdrawalWithdrawal syndromeDetoxification unitEligibility criteriaTremensWithdrawalRiskComorbiditiesPatientsAdmissionHospitalSyndrome