2019
Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”
Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC, Vasiliou V, Nebert DW. Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”. Human Genomics 2019, 13: 11. PMID: 30782214, PMCID: PMC6381713, DOI: 10.1186/s40246-019-0191-9.Peer-Reviewed Original ResearchConceptsMajor urinary protein genesKingdoms of lifeLipocalin gene familyGene familyMUP genesMouse genomeHuman genomeProtein geneChromosome 4Regulation of glucoseBarrel structurePhysiological processesΒ-strandsPhysiological functionsSecretory tissueGenesScent marksPseudogenesGenomeLipid metabolismBloomsEvidence pointsSyntenicImportant roleSteroid hormones
2018
Aldehyde Dehydrogenases☆
Vasiliou V, Thompson D, Petersen D. Aldehyde Dehydrogenases☆. 2018, 146-163. DOI: 10.1016/b978-0-12-801238-3.99183-9.Peer-Reviewed Original ResearchAldehyde dehydrogenasesAldehyde dehydrogenase geneType II hyperprolinemiaTransgenic knockout mouse modelKnockout mouse modelHuman genomeHigh aldehyde dehydrogenase (ALDH) activityDehydrogenase geneExogenous aldehydesCancer stem cellsMolecular basisPhysiological processesDependent enzymesAldehyde dehydrogenase activityMicrophthalmia/anophthalmiaAldehyde dehydrogenaseStem cellsOxidative damageDehydrogenasesSjögren-Larsson syndromeGenesDehydrogenase activityLate-onset Alzheimer's diseasePivotal roleOxidation of aldehydes
2011
Update on the aldehyde dehydrogenase gene (ALDH) superfamily
Jackson B, Brocker C, Thompson DC, Black W, Vasiliou K, Nebert DW, Vasiliou V. Update on the aldehyde dehydrogenase gene (ALDH) superfamily. Human Genomics 2011, 5: 283. PMID: 21712190, PMCID: PMC3392178, DOI: 10.1186/1479-7364-5-4-283.Peer-Reviewed Original ResearchConceptsAldehyde dehydrogenase geneALDH genesDehydrogenase geneALDH family membersGene loss eventsBiotechnology Information gene databaseGamma-hydroxybutyric aciduriaWhole-genome sequencingCellular processesHuman genomeEnzymic detoxificationGene databaseExogenous aldehydesProtein sequencingType II hyperprolinaemiaCancer stem cellsEntire complementMolecular basisALDH enzymesGenesFamily membersStem cellsAldehyde metabolismRetinoic acidSjögren-Larsson syndrome