The Influence of Obesity and Diabetes in the Monkey on Insulin and Glucagon Binding to Liver Membranes*
LOCKWOOD D, HAMILTON C, LIVINGSTON J. The Influence of Obesity and Diabetes in the Monkey on Insulin and Glucagon Binding to Liver Membranes*. Endocrinology 1979, 104: 76-81. PMID: 221171, DOI: 10.1210/endo-104-1-76.Peer-Reviewed Original ResearchConceptsGroup of obese animalsObese animalsInsulin resistanceFasting plasma insulin concentrationInsulin bindingInfluence of obesityGlucagon bindingPlasma glucagon levelsHormone resistanceHypothalamic obesityImpairment of insulin bindingCarbohydrate intoleranceSpontaneous obesityHepatic insulin receptorsDiminished insulinPlasma insulin concentrationsHuman obesityNonketotic diabetesSignificant inverse relationshipObesityPrimate modelGlucagon levelsRhesus monkeysPlasma glucagonDiabetes