The rate of dasotraline brain entry is slow following intravenous administration
Lew R, Constantinescu CC, Holden D, Carson RE, Carroll V, Galluppi G, Koblan KS, Hopkins SC. The rate of dasotraline brain entry is slow following intravenous administration. Psychopharmacology 2020, 237: 3435-3446. PMID: 32813030, PMCID: PMC7651685, DOI: 10.1007/s00213-020-05623-8.Peer-Reviewed Original ResearchConceptsSynaptic dopamine levelsDopamine levelsDAT occupancyPositron emission tomographyIntravenous administrationSynaptic dopamineRhesus monkeysSlow oral absorptionNorepinephrine reuptake inhibitorsBlood-brain barrierHalf-maximal displacementDopamine transporter inhibitionRecreational drug abusersBrain entryResultsIntravenous administrationReuptake inhibitorsPharmacodynamic effectsD2 receptorsRaclopride bindingAssociated elevationDasotralineDrug abusersMethylphenidateTransporter inhibitionEmission tomographyMidbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administration
Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Midbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administration. Biological Psychiatry 2020, 88: 767-776. PMID: 32312578, PMCID: PMC8954711, DOI: 10.1016/j.biopsych.2020.02.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCocaineCocaine-Related DisordersDopamine Uptake InhibitorsExtinction, PsychologicalMesencephalonRatsReceptors, Dopamine D3Self AdministrationConceptsProbabilistic reversalTests of extinctionSubstance-dependent individualsCue-induced reinstatementRelapse-like behaviorTest of motivationAddiction-like behaviorCocaine self-administration behaviorCocaine-taking behaviorReceptor availabilitySelf-administer cocaineIndividual differencesAddicted populationNeurobiological mechanismsSelf-administration behaviorGreater escalationGreater motivationPoor decisionsNeural adaptationD3 receptor availabilityCocaine Self-AdministrationBehavioral biomarkersDecision-making functionsChoice behaviorRate of escalation