2012
Chapter 7 Phosphate Homeostasis Regulatory Mechanisms
Bergwitz C, Jüppner H. Chapter 7 Phosphate Homeostasis Regulatory Mechanisms. 2012, 141-161. DOI: 10.1016/b978-0-12-382040-2.10007-3.ChaptersRegulatory mechanismsBone-forming osteoblastsPi homeostasisMonocyte-macrophage lineage cellsBone-resorbing cellsPi concentrationMacrophage colony-stimulating factorSkeletal developmentFunction of chondrocytesExtracellular matrixLineage cellsMatrix productionOsteogenic cellsMajor functionColony-stimulating factorBone-resorbing osteoclastsPlasma Pi concentrationCellsOsteoblastsIntegral componentFunction of boneRate of bone growthAmbient Pi concentrationsMechanical supportHydroxyapatite crystals
2008
Cellular Mechanism of Decreased Bone in Brtl Mouse Model of OI: Imbalance of Decreased Osteoblast Function and Increased Osteoclasts and Their Precursors*
Uveges TE, Collin‐Osdoby P, Cabral WA, Ledgard F, Goldberg L, Bergwitz C, Forlino A, Osdoby P, Gronowicz GA, Marini JC. Cellular Mechanism of Decreased Bone in Brtl Mouse Model of OI: Imbalance of Decreased Osteoblast Function and Increased Osteoclasts and Their Precursors*. Journal Of Bone And Mineral Research 2008, 23: 1983-1994. PMID: 18684089, PMCID: PMC2686922, DOI: 10.1359/jbmr.080804.Peer-Reviewed Original ResearchConceptsColony-forming unitsRANKL/OPG ratioOsteogenesis imperfectaWildtype valuesCompared to wildtype miceSevere osteogenesis imperfectaReal-time RT-PCRMouse model of OIIncreases osteoclast precursorsBone-resorbing osteoclastsOI therapyKnock-in modelIncreased osteoclastsOsteoclast increaseMarrow culturesWildtype miceModel of OITRACP stainingOsteoblast functionOsteoclast precursorsCellular mechanismsBrtl miceOsteoclastsRT-PCRTRACP(+