2024
Impact of COVID-19 on recorded blood pressure screening and hypertension management in England: an analysis of monthly changes in the quality and outcomes framework indicators in OpenSAFELY
Wiedemann M, Speed V, Cunningham C, Higgins R, Curtis H, Andrews C, Fisher L, Hopcroft L, Rentsch C, Mahalingasivam V, Tomlinson L, Morton C, Samuel M, Green A, Wood C, Brown A, Massey J, Walters C, Smith R, Inglesby P, Evans D, Maude S, Dillingham I, Walker A, Morley J, Mehrkar A, Bacon S, Bates C, Cockburn J, Parry J, Hester F, McManus R, Goldacre B, MacKenna B. Impact of COVID-19 on recorded blood pressure screening and hypertension management in England: an analysis of monthly changes in the quality and outcomes framework indicators in OpenSAFELY. Open Heart 2024, 11: e002732. PMID: 39214534, DOI: 10.1136/openhrt-2024-002732.Peer-Reviewed Original ResearchConceptsBlood pressure screeningPressure screeningPercentage of patientsHypertension prevalenceHypertension managementPopulation-based cohort studyRecord of hypertensionCardiovascular disease managementClinical subgroupsQOF indicatorsScreening ratesPrimary careGeneral practiceHome statusNHS patientsOlder peopleBlood pressure measurementsCare schemesCohort studyDisease managementImpact of COVID-19COVID-19Framework indicatorsNational qualityNHS
2022
Comparison of methods for predicting COVID-19-related death in the general population using the OpenSAFELY platform
Williamson E, Tazare J, Bhaskaran K, McDonald H, Walker A, Tomlinson L, Wing K, Bacon S, Bates C, Curtis H, Forbes H, Minassian C, Morton C, Nightingale E, Mehrkar A, Evans D, Nicholson B, Leon D, Inglesby P, MacKenna B, Davies N, DeVito N, Drysdale H, Cockburn J, Hulme W, Morley J, Douglas I, Rentsch C, Mathur R, Wong A, Schultze A, Croker R, Parry J, Hester F, Harper S, Grieve R, Harrison D, Steyerberg E, Eggo R, Diaz-Ordaz K, Keogh R, Evans S, Smeeth L, Goldacre B. Comparison of methods for predicting COVID-19-related death in the general population using the OpenSAFELY platform. Diagnostic And Prognostic Research 2022, 6: 6. PMID: 35197114, PMCID: PMC8865947, DOI: 10.1186/s41512-022-00120-2.Peer-Reviewed Original ResearchCOVID-19-related deathsInfection prevalenceOpenSAFELY platformGeneral populationNational Statistics mortality dataNumber of comorbiditiesRisk prediction toolsAbsolute risk estimationStatistics mortality dataAbsolute risk estimatesCase-cohort sampleRisk prediction modelTarget populationElectronic health record systemsPrimary careCOVID-19 casesGeneral practiceEmergency careHealth record systemsLocal infection prevalenceNHS EnglandBasic demographicsPrevalenceMortality dataRisk estimatesOverall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform
Bhaskaran K, Rentsch CT, Hickman G, Hulme WJ, Schultze A, Curtis HJ, Wing K, Warren-Gash C, Tomlinson L, Bates CJ, Mathur R, MacKenna B, Mahalingasivam V, Wong A, Walker AJ, Morton CE, Grint D, Mehrkar A, Eggo RM, Inglesby P, Douglas IJ, McDonald HI, Cockburn J, Williamson EJ, Evans D, Parry J, Hester F, Harper S, Evans SJ, Bacon S, Smeeth L, Goldacre B. Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform. PLOS Medicine 2022, 19: e1003871. PMID: 35077449, PMCID: PMC8789178, DOI: 10.1371/journal.pmed.1003871.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsCOVID-19 hospitalisationGeneral population controlsCOVID-19 groupCOVID-19 survivorsHospital admissionHigh riskInfluenza hospitalisationsCause mortalityCohort studyInfluenza patientsPrimary careGeneral populationInitial infectionAcute coronavirus disease 2019Lower respiratory tract infectionsSevere COVID-19 outcomesLong-term adverse outcomesCOVID-19 hospital admissionsSpecific causesPopulation controlsCause-specific hospitalisationRespiratory tract infectionsCause-specific outcomesPotential risk factors
2021
OpenSAFELY: impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic
Collaborative T, Curtis HJ, MacKenna B, Walker AJ, Croker R, Mehrkar A, Morton C, Bacon S, Hickman G, Inglesby P, Bates C, Evans D, Ward T, Cockburn J, Davy S, Bhaskaran K, Schultze A, Rentsch CT, Williamson E, Hulme W, Tomlinson L, Mathur R, Drysdale H, Eggo RM, Wong AY, Forbes H, Parry J, Hester F, Harper S, Douglas I, Smeeth L, Goldacre B. OpenSAFELY: impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic. Open Heart 2021, 8: e001784. PMID: 34785588, PMCID: PMC8595296, DOI: 10.1136/openhrt-2021-001784.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsBlood CoagulationBlood Coagulation TestsCOVID-19Drug MonitoringDrug PrescriptionsDrug SubstitutionDrug UtilizationEnglandFactor Xa InhibitorsFemaleHumansMaleMiddle AgedPatient SafetyPractice Guidelines as TopicPractice Patterns, Physicians'Primary Health CareRetrospective StudiesRisk AssessmentRisk FactorsState MedicineWarfarinConceptsWarfarin patientsNational Health ServiceCOVID-19 pandemicNational guidanceCare home residencyINR test resultsRenal function testsFrequent blood testingSafety alertsRoutine clinical dataAtrial fibrillation diagnosisElevated INRMedication changesOral anticoagulantsAnticoagulant therapyCohort studyAppropriate patientsINR testsFunction testsBlood testingPrimary careClinical dataDOACPatientsWarfarinSeverity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England
Grint DJ, Wing K, Houlihan C, Gibbs HP, Evans SJW, Williamson E, McDonald HI, Bhaskaran K, Evans D, Walker AJ, Hickman G, Nightingale E, Schultze A, Rentsch CT, Bates C, Cockburn J, Curtis HJ, Morton CE, Bacon S, Davy S, Wong AYS, Mehrkar A, Tomlinson L, Douglas IJ, Mathur R, MacKenna B, Ingelsby P, Croker R, Parry J, Hester F, Harper S, DeVito NJ, Hulme W, Tazare J, Smeeth L, Goldacre B, Eggo RM. Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England. Clinical Infectious Diseases 2021, 75: e1120-e1127. PMID: 34487522, PMCID: PMC8522415, DOI: 10.1093/cid/ciab754.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 alpha variantHospital admissionAlpha variantWild-type virusCox proportional hazards regressionS gene target failureIntensive care unitProportional hazards regressionSARS-CoV-2Pathways of diseaseHigher hazardWild-type casesCause deathCause mortalityCare unitHazards regressionIndividual-level demographicsPrimary careCommunity testingInfection incidenceNHS EnglandDeath dataHigh transmissibilityAdmissionSeverityClinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY
Walker AJ, MacKenna B, Inglesby P, Tomlinson L, Rentsch CT, Curtis HJ, Morton CE, Morley J, Mehrkar A, Bacon S, Hickman G, Bates C, Croker R, Evans D, Ward T, Cockburn J, Davy S, Bhaskaran K, Schultze A, Williamson EJ, Hulme WJ, McDonald HI, Mathur R, Eggo RM, Wing K, Wong AY, Forbes H, Tazare J, Parry J, Hester F, Harper S, O’Hanlon S, Eavis A, Jarvis R, Avramov D, Griffiths P, Fowles A, Parkes N, Douglas IJ, Evans SJ, Smeeth L, Goldacre B, . Clinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY. British Journal Of General Practice 2021, 71: bjgp.2021.0301. PMID: 34340970, PMCID: PMC8340730, DOI: 10.3399/bjgp.2021.0301.Peer-Reviewed Original ResearchConceptsLong COVIDEnglish primary carePrimary careDiagnostic codesPopulation-based cohort studyAcute COVID-19Different diagnostic thresholdsProportion of peoplePlanning of servicesPersistent symptomsCohort studyGeneral practiceClinicians' understandingDiagnostic thresholdNHS EnglandPatient recordsClinical codesClinical codingCareCOVID-19East of EnglandPatientsDemographic factorsCOVIDWeeks