2020
Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity
Xu J, Liu RJ, Fahey S, Frick L, Leckman J, Vaccarino F, Duman RS, Williams K, Swedo S, Pittenger C. Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity. American Journal Of Psychiatry 2020, 178: 48-64. PMID: 32539528, PMCID: PMC8573771, DOI: 10.1176/appi.ajp.2020.19070698.Peer-Reviewed Original ResearchConceptsStriatal cholinergic interneuronsCholinergic interneuronsMouse brain slicesObsessive-compulsive disorderControl subjectsBrain slicesPediatric autoimmune neuropsychiatric disordersIntravenous immunoglobulin treatmentAutoimmune neuropsychiatric disordersAcute mouse brain slicesParvalbumin-expressing GABAergic interneuronsPediatric obsessive-compulsive disorderBrain antigensImmunoglobulin treatmentBaseline serumStreptococcal infectionCritical cellular targetsSymptom improvementGABAergic interneuronsInduced autoimmunityIgG antibodiesMouse slicesIndependent cohortBehavioral pathologyNeuron types
2001
Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase
Patterson S, Pittenger C, Morozov A, Martin K, Scanlin H, Drake C, Kandel E. Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase. Neuron 2001, 32: 123-140. PMID: 11604144, DOI: 10.1016/s0896-6273(01)00443-3.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsBrain-Derived Neurotrophic FactorCell NucleusColforsinCyclic AMPDendritesExcitatory Postsynaptic PotentialsLigandsLong-Term PotentiationMembrane PotentialsMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMicroscopy, ImmunoelectronMitogen-Activated Protein KinasesNeuronal PlasticityPhosphorylationPresynaptic TerminalsReceptor, trkBTheta Rhythm